Properties of the Evoked Spatio-Temporal Electrical Activity in Neuronal Assemblies

Properties of neural computation were studied in two types of neuronal networks: isolated leech ganglia and neuronal cultures of dissociated cortical neurons from neonatal rats. With appropriate experimental set-ups it was possible to obtain a precise description of the spread of excitation induced by specific inputs. The evoked spatio-temporal electrical activity was characterized by large variability and the electrical activity of neurons activated by the same stimulation was found to be statistically independent to a high degree. The variability presumably originates from basic properties of synaptic transmission, which is stochastic in nature. As a consequence, the large variability of the evoked spatio-temporal electrical activity appears to be a general property of neural computation and a typical feature of neuronal assemblies. It is shown, however, that the observed statistical independence of co-activated neurons may be used to reduce the effects of variability by appropriately averaging or pooling the electrical activity.

[1]  Y. Jimbo,et al.  Electrical stimulation and recording from cultured neurons using a planar electrode array , 1992 .

[2]  D. Barth,et al.  Thalamic modulation of high-frequency oscillating potentials in auditory cortex , 1996, Nature.

[3]  Peter Dayan,et al.  The Effect of Correlated Variability on the Accuracy of a Population Code , 1999, Neural Computation.

[4]  A V Herz,et al.  Neural codes: firing rates and beyond. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[5]  John G. Proakis,et al.  Probability, random variables and stochastic processes , 1985, IEEE Trans. Acoust. Speech Signal Process..

[6]  Yasuhiko Jimbo,et al.  The dynamics of a neuronal culture of dissociated cortical neurons of neonatal rats , 2000, Biological Cybernetics.

[7]  A. E. Stuart.  Physiological and morphological properties of motoneurones in the central nervous system of the leech , 1970, The Journal of physiology.

[8]  Simon B. Laughlin,et al.  Form and function in retinal processing , 1987, Trends in Neurosciences.

[9]  William R. Softky,et al.  The highly irregular firing of cortical cells is inconsistent with temporal integration of random EPSPs , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[10]  D. Snodderly,et al.  Response Variability of Neurons in Primary Visual Cortex (V1) of Alert Monkeys , 1997, The Journal of Neuroscience.

[11]  W. Kristan,et al.  A neuronal network for computing population vectors in the leech , 1998, Nature.

[12]  O. Prospero-Garcia,et al.  Reliability of Spike Timing in Neocortical Neurons , 1995 .

[13]  Stefano Battiston,et al.  Neural Computation in the Leech Ganglion , 1998, ICONIP.

[14]  J J Jack,et al.  The variance of successive peaks in synaptic amplitude histograms: effects of inter-site differences in quantal size , 1995, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[15]  G D Lewen,et al.  Reproducibility and Variability in Neural Spike Trains , 1997, Science.

[16]  W. O. Friesen,et al.  Neuronal control of leech swimming. , 1995, Journal of neurobiology.

[17]  A. S. French,et al.  The Efficiency of Sensory Information Coding by Mechanoreceptor Neurons , 1997, Neuron.

[18]  W. Bialek,et al.  Naturalistic stimuli increase the rate and efficiency of information transmission by primary auditory afferents , 1995, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[19]  T. Sejnowski,et al.  Heterogeneous Release Properties of Visualized Individual Hippocampal Synapses , 1997, Neuron.

[20]  M. Egelhaaf,et al.  Variability in spike trains during constant and dynamic stimulation. , 1999, Science.

[21]  J J Jack,et al.  Assessment of the reliability of amplitude histograms from excitatory synapses in rat hippocampal CA1 In Vitro , 1997, The Journal of physiology.

[22]  R. Malinow,et al.  The probability of transmitter release at a mammalian central synapse , 1993, Nature.

[23]  W. O. Friesen,et al.  Neuronal generation of the leech swimming movement. , 1978, Science.

[24]  C. Stevens,et al.  Input synchrony and the irregular firing of cortical neurons , 1998, Nature Neuroscience.

[25]  A. Kawana,et al.  Simultaneous measurement of intracellular calcium and electrical activity from patterned neural networks in culture , 1993, IEEE Transactions on Biomedical Engineering.

[26]  D. Baylor,et al.  Specific modalities and receptive fields of sensory neurons in CNS of the leech. , 1968, Journal of neurophysiology.

[27]  Richard Lippmann,et al.  Review of Neural Networks for Speech Recognition , 1989, Neural Computation.

[28]  W. Newsome,et al.  The Variable Discharge of Cortical Neurons: Implications for Connectivity, Computation, and Information Coding , 1998, The Journal of Neuroscience.

[29]  B. Knight,et al.  Response variability and timing precision of neuronal spike trains in vivo. , 1997, Journal of neurophysiology.

[30]  G. Stent,et al.  Neurobiology of the Leech , 1981 .

[31]  T. Poggio,et al.  Biophysics of Computation: Neurons, Synapses and Membranes , 1984 .

[32]  H. Markram,et al.  Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex. , 1997, The Journal of physiology.

[33]  William Bialek,et al.  Spikes: Exploring the Neural Code , 1996 .

[34]  William Bialek,et al.  Reliability and information transmission in spiking neurons , 1992, Trends in Neurosciences.

[35]  C. Stevens,et al.  An evaluation of causes for unreliability of synaptic transmission. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[36]  D. Baylor,et al.  Origin of reproducibility in the responses of retinal rods to single photons. , 1998, Biophysical journal.

[37]  D. Kleinfeld,et al.  Visual stimuli induce waves of electrical activity in turtle cortex. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[38]  W. Singer,et al.  Long-range synchronization of oscillatory light responses in the cat retina and lateral geniculate nucleus , 1996, Nature.

[39]  A. Larkman,et al.  The reliability of excitatory synaptic transmission in slices of rat visual cortex in vitro is temperature dependent , 1998, The Journal of physiology.