Fetal membrane healing after spontaneous and iatrogenic membrane rupture: a review of current evidence.

In view of the important protective role of the fetal membranes, wound sealing, tissue regeneration, or wound healing could be life saving in cases of preterm premature rupture of the membranes. Although many investigators are studying the causes of preterm premature rupture of membranes, the emphasis has not been on the wound healing capacity of the fetal membranes. In this review, the relevant literature on the pathophysiologic condition that leads to preterm premature rupture of membranes will be summarized to emphasize a continuum of events between rupture and repair. We will present the current knowledge on fetal membrane wound healing and discuss the clinical implications of these findings. We will critically discuss recent experimental interventions in women to seal or heal the fetal membranes after preterm premature rupture of membranes.

[1]  M. Harrison.  Surgically correctable fetal disease. , 2000, American journal of surgery.

[2]  Passloer Hj.  Problematik und Praktikabilität der Fibrinklebung beim frühen vorzeitigen Blasensprung , 1989 .

[3]  G. L. Wideman,et al.  ASCORBIC ACID DEFICIENCY AND PREMATURE RUPTURE OF FETAL MEMBRANES. , 1964, American journal of obstetrics and gynecology.

[4]  Alyssa A Mills,et al.  Outcome of pregnancies complicated by ruptured membranes after genetic amniocentesis. , 2000, American journal of obstetrics and gynecology.

[5]  Knight C rd,et al.  The effect of labor on the rheologic response of chorioamniotic membranes. , 1982 .

[6]  J. Killeen,et al.  A relaxin-mediated pathway to preterm premature rupture of the fetal membranes that is independent of infection. , 1998, American journal of obstetrics and gynecology.

[7]  J. Barton,et al.  Gelatin Sponge Embolization , 2002, Fetal Diagnosis and Therapy.

[8]  J. Deprest,et al.  A histological study of fetoscopic membrane defects to document membrane healing. , 2006, Placenta.

[9]  S. Bell,et al.  Structural characteristics of term human fetal membranes prior to labour: identification of an area of altered morphology overlying the cervix. , 1999, Human reproduction.

[10]  D. Poppas,et al.  Ex vivo evaluation of human fetal membrane closure , 2002, Lasers in surgery and medicine.

[11]  G. González-Ávila,et al.  Collagen Metabolism in Premature Rupture of Amniotic Membranes , 1990, Obstetrics and gynecology.

[12]  J. Queenan,et al.  Age and resting follicle number predict response to gonadotropin stimulation in in vitro fertilization cycles. , 2002, American Journal of Obstetrics and Gynecology.

[13]  H. Hall,et al.  In vitro lesion repair by human amnion epithelial and mesenchymal cells. , 2004, American journal of obstetrics and gynecology.

[14]  W. Lewin.  Acute subdural and extradural haematoma in closed head injuries. , 1949, Annals of the Royal College of Surgeons of England.

[15]  R. Quintero,et al.  In vitro laser welding of amniotic membranes , 1999, Lasers in surgery and medicine.

[16]  R. Quintero,et al.  Surgical treatment of spontaneous rupture of membranes: the amniograft--first experience. , 2002, American journal of obstetrics and gynecology.

[17]  K. Uchide,et al.  Intracervical fibrin instillation as an adjuvant to treatment for second trimester rupture of membranes , 1994, Archives of Gynecology and Obstetrics.

[18]  I. Timor-Tritsch,et al.  The Closure of Iatrogenic Membrane Defects after Amniocentesis and Endoscopic Intrauterine Procedures , 2004, Fetal Diagnosis and Therapy.

[19]  S. Özalp,et al.  Maternal blood clot patch therapy: a model for postamniocentesis amniorrhea. , 1997, American journal of obstetrics and gynecology.

[20]  J. Barton,et al.  An aggressive interventional protocol for early midtrimester premature rupture of the membranes using gelatin sponge for cervical plugging. , 2002, American journal of obstetrics and gynecology.

[21]  J. Deprest,et al.  Successful sealing of fetoscopic access sites with collagen plugs in the rabbit model. , 2000, American journal of obstetrics and gynecology.

[22]  J. Deprest,et al.  Increased polymorphonuclear infiltration and iatrogenic amniotic band after closure of fetoscopic access sites with a bioactive membrane in the rabbit at midgestation. , 2003, American journal of obstetrics and gynecology.

[23]  R. Ohira,et al.  An autocrine/paracrine role of human decidual relaxin. II. Stromelysin-1 (MMP-3) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1). , 1997, Biology of reproduction.

[24]  S. Moser,et al.  The technique of fibrin adhesion for premature rupture of the membranes during pregnancy , 1986, Journal of perinatal medicine.

[25]  M. Van Ranst,et al.  Successful patching of iatrogenic rupture of the fetal membranes. , 2004, Placenta.

[26]  L. Millar,et al.  Decidual relaxins: gene and protein up-regulation in preterm premature rupture of the membranes by complementary DNA arrays and quantitative immunocytochemistry. , 2002, American journal of obstetrics and gynecology.

[27]  R. Romero,et al.  Transabdominal intra-amniotic endoscopic assessment of previable premature rupture of membranes. , 1998, American journal of obstetrics and gynecology.

[28]  J. Deprest,et al.  Matrix Metalloproteinases-2 and -9 and Their Endogenous Tissue Inhibitors in Tissue Remodeling After Sealing of the Fetal Membranes in a Sheep Model of Fetoscopic Surgery , 2002, The Journal of the Society for Gynecologic Investigation: JSGI.

[29]  J. Aplin,et al.  Brief communication: sliding displacement of amnion and chorion following controlled laser wounding suggests a mechanism for short-term sealing of ruptured membranes. , 1994, Placenta.

[30]  D. Sopher.  The response of rat fetal membranes to injury. , 1972, Annals of the Royal College of Surgeons of England.

[31]  S. Fortunato,et al.  Distinct molecular events suggest different pathways for preterm labor and premature rupture of membranes. , 2001, American journal of obstetrics and gynecology.

[32]  W. Mulla,et al.  Intracervical fibrin sealants: a potential treatment for early preterm premature rupture of the membranes. , 2001, American journal of obstetrics and gynecology.

[33]  R. Quintero,et al.  Repair kinetics of amnion cells after microsurgical injury. , 1996, Fetal diagnosis and therapy.

[34]  R. Berkowitz,et al.  In vitro studies of the interactions between platelets and amniotic membranes: a potential treatment for preterm premature rupture of the membranes. , 1998, American Journal of Obstetrics and Gynecology.

[35]  R. Porreco,et al.  Elevated protease activities in human amnion and chorion correlate with preterm premature rupture of membranes. , 1995, American journal of obstetrics and gynecology.

[36]  P. Taylor,et al.  J Soc Gynecol Investig , 2005 .

[37]  J. Garibay-Tupas,et al.  An autocrine/paracrine role of human decidual relaxin. I. Interstitial collagenase (matrix metalloproteinase-1) and tissue plasminogen activator. , 1997, Biology of reproduction.

[38]  Roberto Romero,et al.  The fetal inflammatory response syndrome. , 1998, American journal of obstetrics and gynecology.

[39]  R. Quintero,et al.  New horizons in the treatment of preterm premature rupture of membranes. , 2001, Clinics in perinatology.

[40]  G. Leparc,et al.  Treatment of iatrogenic previable premature rupture of membranes with intra-amniotic injection of platelets and cryoprecipitate (amniopatch): preliminary experience. , 1999, American journal of obstetrics and gynecology.

[41]  J. Deprest,et al.  Matrix metalloproteinases -2 and -9 and their endogenous tissue inhibitors in fetal membrane repair following fetoscopy in a rabbit model. , 2000, Molecular human reproduction.

[42]  T. Hyslop,et al.  In vitro sealing of punctured fetal membranes: potential treatment for midtrimester premature rupture of membranes. , 2001, American journal of obstetrics and gynecology.

[43]  I. Timor-Tritsch,et al.  Endoscopic closure of fetal membrane defects: comparing iatrogenic versus spontaneous rupture cases. , 2004, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[44]  C. Lockwood,et al.  Minimally invasive endoscopy in the treatment of preterm premature rupture of membranes by application of fibrin sealant , 2000, Journal of perinatal medicine.

[45]  J. W. Johnson,et al.  Cases with ruptured membranes that "reseal". , 1990, American journal of obstetrics and gynecology.

[46]  J. Deprest,et al.  An organ-culture for in vitro evaluation of fetal membrane healing capacity. , 2000, European journal of obstetrics, gynecology, and reproductive biology.

[47]  G. Bryant-Greenwood,et al.  The extracellular matrix of the human fetal membranes: structure and function. , 1998, Placenta.

[48]  H. Redl,et al.  Fibrin Sealant in Operative Medicine , 1986, Springer Berlin Heidelberg.

[49]  A. Singer,et al.  Cutaneous wound healing. , 1999, The New England journal of medicine.

[50]  K. Laurence,et al.  DEFECT IN FETAL MEMBRANES AFTER FETOSCOPY , 1978, The Lancet.

[51]  H. Redl,et al.  Properties of Different Tissue Sealants with Special Emphasis on Fibrinogen-Based Preparations , 1986 .