The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide.

[1]  J. Coligan,et al.  Cutting Edge: Mouse CD300f (CMRF-35–Like Molecule-1) Recognizes Outer Membrane-Exposed Phosphatidylserine and Can Promote Phagocytosis , 2011, The Journal of Immunology.

[2]  Dianqing Wu,et al.  Phospholipase C-β3 regulates FcɛRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1. , 2011, Immunity.

[3]  T. Abe,et al.  TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury , 2010, The Journal of experimental medicine.

[4]  A. Shibuya,et al.  An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E–mediated immediate hypersensitivity reactions , 2010, Nature Immunology.

[5]  M. van Lookeren Campagne,et al.  Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1 , 2010, The Journal of experimental medicine.

[6]  T. Kawakami,et al.  Mast cells in atopic dermatitis. , 2009, Current opinion in immunology.

[7]  Yutaka Enomoto,et al.  An Activating and Inhibitory Signal from an Inhibitory Receptor LMIR3/CLM-1: LMIR3 Augments Lipopolysaccharide Response through Association with FcRγ in Mast Cells1 , 2009, The Journal of Immunology.

[8]  Stephen J Galli,et al.  New developments in mast cell biology , 2008, Nature Immunology.

[9]  S. Yamasaki,et al.  Mincle is an ITAM-coupled activating receptor that senses damaged cells , 2008, Nature Immunology.

[10]  Hideaki Nakajima,et al.  Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells. , 2008, Blood.

[11]  G. Freeman,et al.  TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. , 2007, Immunity.

[12]  Seung Hun Lee,et al.  Topical application of a novel ceramide derivative, K6PC-9, inhibits dust mite extract-induced atopic dermatitis-like skin lesions in NC/Nga mice. , 2007, International immunopharmacology.

[13]  S. Nagata,et al.  Identification of Tim4 as a phosphatidylserine receptor , 2007, Nature.

[14]  Victor L. J. Tybulewicz,et al.  Functional Analysis of Activating Receptor LMIR4 as a Counterpart of Inhibitory Receptor LMIR3* , 2007, Journal of Biological Chemistry.

[15]  J. Kinet,et al.  New developments in FcεRI regulation, function and inhibition , 2007, Nature Reviews Immunology.

[16]  A. Nakamura,et al.  Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation , 2007, The Journal of experimental medicine.

[17]  M. Cabot,et al.  Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. , 2006, Biochimica et biophysica acta.

[18]  C. Chen,et al.  Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo. , 2005, The American journal of pathology.

[19]  Takashi Saito,et al.  NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[20]  Xudong Wei,et al.  Mast Cells, FcεRI, and IL-13 Are Required for Development of Airway Hyperresponsiveness after Aerosolized Allergen Exposure in the Absence of Adjuvant1 , 2004, The Journal of Immunology.

[21]  W. Seaman,et al.  CMRF-35-Like Molecule-1, a Novel Mouse Myeloid Receptor, Can Inhibit Osteoclast Formation1 , 2003, The Journal of Immunology.

[22]  T. Kitamura,et al.  Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics. , 2003, Experimental hematology.

[23]  Toshiaki Kawakami,et al.  Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcεRI , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[24]  N. Copeland,et al.  Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells. , 2003, Biochemical and biophysical research communications.

[25]  D. Tenen,et al.  Paired Activating and Inhibitory Immunoglobulin-like Receptors, MAIR-I and MAIR-II, Regulate Mast Cell and Macrophage Activation , 2003, The Journal of experimental medicine.

[26]  Toshiaki Kawakami,et al.  Regulation of mast-cell and basophil function and survival by IgE , 2002, Nature Reviews Immunology.

[27]  R. Kolesnick.  The therapeutic potential of modulating the ceramide/sphingomyelin pathway. , 2002, The Journal of clinical investigation.

[28]  K. Jakobs,et al.  Sphingosylphosphorylcholine-biological functions and mechanisms of action. , 2002, Biochimica et biophysica acta.

[29]  D. Friend,et al.  Increased Severity of Local and Systemic Anaphylactic Reactions in Gp49b1-Deficient Mice , 2001, The Journal of experimental medicine.

[30]  L. Lanier,et al.  Immune inhibitory receptors. , 2000, Science.

[31]  S. Galli,et al.  Mast Cells Can Amplify Airway Reactivity and Features of Chronic Inflammation in an Asthma Model in Mice , 2000, The Journal of experimental medicine.

[32]  T. Kitamura,et al.  Plat-E: an efficient and stable system for transient packaging of retroviruses , 2000, Gene Therapy.

[33]  T. Yoshino,et al.  Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG , 1999, The Journal of experimental medicine.

[34]  F. Alt,et al.  Involvement of Bruton's Tyrosine Kinase in FcεRI-dependent Mast Cell Degranulation and Cytokine Production , 1998, The Journal of experimental medicine.

[35]  M. Cooper,et al.  A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[36]  P. Tempst,et al.  Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB , 1996, Nature.

[37]  W. Fridman,et al.  Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors. , 1995, The Journal of clinical investigation.

[38]  J. Kinet,et al.  Complete structure and expression in transfected cells of high affinity IgE receptor , 1989, Nature.

[39]  J. Cannon,et al.  Specific lipid recognition is a general feature of CD300 and TREM molecules , 2011, Immunogenetics.

[40]  J. O’Shea,et al.  Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation , 2002, Nature Immunology.