Neuromuscular complications associated with liver transplantation

We studied neuromuscular complications in a cohort of 520 patients with liver transplantation. Perioperative mononeuropathy developed in 9 patients. The peroneal nerve, radial nerve, and cutaneous branch of the femoral nerve were affected in 2 patients each. Two patients had herpes zoster‐associated radiculopathy, and 1 patient had Horner's syndrome. Recovery was good in most patients. In 7 patients, severe quadriplegia complicated the perioperative course. In 5 patients, electrophysiologic studies suggested acute necrotic myopathy, and muscle biopsy specimens showed evidence of rhabdomyolysis in 1 patient. Outcome in survivors was good, all recovering completely. We conclude that neuromuscular complications in liver transplantation are uncommon (less than 1%) and do not significantly contribute to morbidity. Mononeuropathies may have iatrogenic perioperative causes, and rhabdomyolysis may be an important cause of generalized muscle weakness after liver transplantation. © John Wiley & Sons, Inc.

[1]  R. Wiesner,et al.  FK506‐induced neurotoxicity in liver transplantation , 1994, Annals of neurology.

[2]  A. Pestronk,et al.  Rapidly evolving myopathy with myosin‐deficient muscle fibers , 1994, Annals of neurology.

[3]  D. Ramsay,et al.  Acute necrotizing myopathy of intensive care: Electrophysiological studies , 1994, Muscle & nerve.

[4]  J. Mendell,et al.  Polyneuropathy complicating bone marrow and solid organ transplantation , 1993, Neurology.

[5]  C. Lumbreras,et al.  Neurologic complications in liver transplantation , 1993, Acta neurologica Scandinavica.

[6]  W. Carey,et al.  Neurological complications following liver transplantation , 1992, Annals of neurology.

[7]  B. Andrews,et al.  Neurologic complications of cardiac transplantation. , 1990, The Western journal of medicine.

[8]  T. Spitzer,et al.  Incapacitating peripheral neuropathy as a manifestation of chronic graft-versus-host disease. , 1990, Bone marrow transplantation.

[9]  T. Starzl,et al.  Liver transplantation. , 1989, The Johns Hopkins medical journal.

[10]  W. Carey,et al.  NEUROLOGIC COMPLICATIONS OF LIVER TRANSPLANTATION , 1988, Transplantation.

[11]  M. Noppen,et al.  Cyclosporine and myopathy. , 1987, Annals of internal medicine.

[12]  G. Forbes,et al.  Central Nervous System Toxicity after Liver Transplantation , 1987 .

[13]  J. Hiatt,et al.  The First 100 Liver Transplants at UCLA , 1987, Annals of surgery.