Novel indices of ventricular repolarization to screen post myocardial infarction patients

We propose novel indices of ventricular repolarization intervals, the JTp/JT, Tpe/JTp and Tpe/JT ratios. These indices have been compared with the duration of the ventricular repolarization intervals and other ratios in 17 normal subjects and 17 patients with old myocardial infarction. In the intervals and other ratios, the best separation between groups is obtained with the Tpe/QTp and Tpe/QT ratios with 94% sensitivity and 82% specificity, the proposed ratios increased sensitivity to 100% and specificity to 94%. These indices should be further tested to determine their usefulness in discriminating between OMI patients with and without susceptibility to ventricular arrhythmias.

[1]  A J Camm,et al.  Comparative Reproducibility of QT, QT Peak, and T Peak‐T End Intervals and Dispersion in Normal Subjects, Patients with Myocardial Infarction, and Patients with Hypertrophic Cardiomyopathy , 1998, Pacing and clinical electrophysiology : PACE.

[2]  M. Franz,et al.  Comparison of ECG Variables of Dispersion of Ventricular Repolarization with Direct Myocardial Repolarization Measurements in the Human Heart , 1998, Journal of cardiovascular electrophysiology.

[3]  L Oikarinen,et al.  Dispersions of the QT interval in postmyocardial infarction patients presenting with ventricular tachycardia or with ventricular fibrillation. , 1998, The American journal of cardiology.

[4]  B. Surawicz,et al.  Long QT: good, bad or indifferent? , 1984, Journal of the American College of Cardiology.

[5]  J. Bourke,et al.  Importance of lead selection in QT interval measurement. , 1988, The American journal of cardiology.

[6]  C. Antzelevitch,et al.  Electrophysiological Characteristics of the M Cell , 1997 .

[8]  M. Malik,et al.  Relation of ventricular repolarization to cardiac cycle length in normal subjects, hypertrophic cardiomyopathy, and patients with myocardial infarction , 1999, Clinical cardiology.

[9]  M. Viitasalo,et al.  Electrocardiographic measures of ventricular repolarisation dispersion in patients with coronary artery disease susceptible to ventricular fibrillation , 1998, Heart.

[11]  V. Fuster,et al.  Sudden death in coronary artery disease: acute ischemia versus myocardial substrate. , 1997, Circulation.

[12]  S. Cessie,et al.  Dispersion of ventricular repolarization and arrhythmic cardiac death in coronary artery disease. , 1994, The American journal of cardiology.

[13]  M. Radomski,et al.  The Terminal Portion of the T Wave: A New Electrocardiographic Marker of Risk of Ventricular Arrhythmias , 2000, Pacing and clinical electrophysiology : PACE.

[14]  P. Davey,et al.  QT interval measurement: Q to TApex or Q to TEnd? , 1999, Journal of internal medicine.

[15]  J. O'Donnell,et al.  Behavior of the terminal T wave during exercise in normal subjects, patients with symptomatic coronary artery disease and apparently healthy subjects with abnormal ST segment depression. , 1985, Journal of the American College of Cardiology.

[16]  H. H. Friedman,et al.  Diagnostico electrocardiográfico y vectocardiográfico , 1989 .

[17]  Josef Kautzner,et al.  QT interval measurements. , 2002, Cardiac electrophysiology review.

[18]  H V Huikuri,et al.  Dispersion of QT interval in patients with and without susceptibility to ventricular tachyarrhythmias after previous myocardial infarction. , 1995, Journal of the American College of Cardiology.

[19]  M R Franz,et al.  Electrocardiographic indexes of dispersion of ventricular repolarization: an isolated heart validation study. , 1995, Journal of the American College of Cardiology.

[20]  J L Willems,et al.  Common standards for quantitative electrocardiography. , 1985, Journal of medical engineering & technology.

[21]  C Zywietz,et al.  Common Standards for Quantitative Electrocardiography: Goals and Main Results , 1990, Methods of Information in Medicine.

[22]  D Durrer,et al.  Mechanism and Time Course of S‐T and T‐Q Segment Changes during Acute Regional Myocardial Ischemia in the Pig Heart Determined by Extracellular and Intracellular Recordings , 1978, Circulation research.

[23]  M. Franz,et al.  Monophasic Action Potentials , 1997, Springer Berlin Heidelberg.

[24]  F. Terry Good, bad or indifferent? , 1890, NATNews.

[25]  A J Moss,et al.  Long QT syndrome. New electrocardiographic characteristics. , 1990, Circulation.

[26]  A. Moss,et al.  The Long-QT Syndrome , 1992 .

[27]  P. Davey,et al.  QT interval and mortality from coronary artery disease. , 2000, Progress in cardiovascular diseases.