Rational Design of Multifunctional Upconversion Nanocrystals/Polymer Nanocomposites for Cisplatin (IV) Delivery and Biomedical Imaging

By combining upconversion nanoparticles with the cisplatin (IV) prodrug we have demonstrated that a stable and multifunctional drug delivery system can be designed that will both reduce the drawbacks of cisplatin and give insight in to its in vitro/in vivo imaging. The up/down-conversion fluorescence are detectable and show obvious co-localization, demonstrating that the nanoparticles are rather stable inside cells and retain the UCNPs and block copolymer.

[1]  Jianhua Hao,et al.  Electric-induced enhancement and modulation of upconversion photoluminescence in epitaxial BaTiO3:Yb/Er thin films. , 2011, Angewandte Chemie.

[2]  Chun-Hua Yan,et al.  Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals. , 2011, Biomaterials.

[3]  X. Jing,et al.  A prodrug strategy to deliver cisplatin(IV) and paclitaxel in nanomicelles to improve efficacy and tolerance. , 2012, Biomaterials.

[4]  Paras N. Prasad,et al.  (α-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging. , 2012, ACS nano.

[5]  Jun Lin,et al.  Rare earth fluoride nano-/microcrystals: synthesis, surface modification and application , 2010 .

[6]  Jun Lin,et al.  Well-dispersed KRE3F10 (RE = Sm–Lu, Y) nanocrystals: solvothermal synthesis and luminescence properties , 2012 .

[7]  M. Duffy,et al.  Survivin: a new target for anti-cancer therapy. , 2009, Cancer treatment reviews.

[8]  Chunhua Yan,et al.  Rare earth upconversion nanophosphors: synthesis, functionalization and application as biolabels and energy transfer donors , 2010 .

[9]  Xueyuan Chen,et al.  Upconversion nanoparticles in biological labeling, imaging, and therapy. , 2010, The Analyst.

[10]  Ya-Wen Zhang,et al.  High-quality sodium rare-earth fluoride nanocrystals: controlled synthesis and optical properties. , 2006, Journal of the American Chemical Society.

[11]  J. Hao,et al.  Thermally controlled release of anticancer drug from self-assembled γ-substituted amphiphilic poly(ε-caprolactone) micellar nanoparticles. , 2012, Biomacromolecules.

[12]  X. Jing,et al.  The use of polymeric platinum(IV) prodrugs to deliver multinuclear platinum(II) drugs with reduced systemic toxicity and enhanced antitumor efficacy. , 2012, Biomaterials.

[13]  Mandip Singh,et al.  Anticancer activity of Noscapine, an opioid alkaloid in combination with Cisplatin in human non-small cell lung cancer. , 2011, Lung cancer.

[14]  Jun Lin,et al.  Poly(acrylic acid)-modified Fe3O4 microspheres for magnetic-targeted and pH-triggered anticancer drug delivery. , 2012, Chemistry.

[15]  Nora Khanarian,et al.  In vivo and scanning electron microscopy imaging of up-converting nanophosphors in Caenorhabditis elegans. , 2006, Nano letters.

[16]  Kai Yang,et al.  In Vitro and In Vivo Near‐Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles , 2012, Advanced materials.

[17]  S. Schmid,et al.  ATP is required for receptor-mediated endocytosis in intact cells , 1990, The Journal of cell biology.

[18]  H. Maeda.  Macromolecular therapeutics in cancer treatment: the EPR effect and beyond. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[19]  Y. Dong,et al.  Systematic functional analysis of the Caenorhabditis elegans genome using RNAi , 2003, Nature.

[20]  Meifang Zhu,et al.  Construction of 980 nm laser-driven dye-sensitized photovoltaic cell with excellent performance for powering nanobiodevices implanted under the skin , 2012 .

[21]  Juewon Kim,et al.  The effect of TAT conjugated platinum nanoparticles on lifespan in a nematode Caenorhabditis elegans model. , 2010, Biomaterials.

[22]  M Marsh,et al.  The structural era of endocytosis. , 1999, Science.

[23]  C. S. Lim,et al.  Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping , 2010, Nature.

[24]  S Thayumanavan,et al.  Multi-stimuli sensitive amphiphilic block copolymer assemblies. , 2009, Journal of the American Chemical Society.

[25]  Kee-Sun Sohn,et al.  Simultaneous Optimization of Luminance and Color Chromaticity of Phosphors Using a Nondominated Sorting Genetic Algorithm , 2010 .

[26]  A. Wyllie,et al.  Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics , 1972, British Journal of Cancer.

[27]  Michael O. Hengartner,et al.  Finding function in novel targets: C. elegans as a model organism , 2006, Nature Reviews Drug Discovery.

[28]  I. Herskowitz,et al.  Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[29]  H. Dai,et al.  Soluble single-walled carbon nanotubes as longboat delivery systems for platinum(IV) anticancer drug design. , 2007, Journal of the American Chemical Society.

[30]  L. Kèlland,et al.  The resurgence of platinum-based cancer chemotherapy , 2007, Nature Reviews Cancer.

[31]  Mingdong Huang,et al.  Amine-functionalized lanthanide-doped KGdF4 nanocrystals as potential optical/magnetic multimodal bioprobes. , 2012, Journal of the American Chemical Society.

[32]  Byeong-Su Kim,et al.  Multicomponent nanoparticles via self-assembly with cross-linked block copolymer surfactants. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[33]  O. Wolfbeis,et al.  Upconverting luminescent nanoparticles for use in bioconjugation and bioimaging. , 2010, Current opinion in chemical biology.

[34]  V. Rottiers,et al.  A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span. , 2001, Developmental cell.

[35]  Taeghwan Hyeon,et al.  Ultra-large-scale syntheses of monodisperse nanocrystals , 2004, Nature materials.

[36]  D. Hall,et al.  Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans , 2002, Nature.

[37]  Zhuang Liu,et al.  Upconversion nanophosphors for small-animal imaging. , 2012, Chemical Society reviews.

[38]  Tian Xia,et al.  Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model. , 2011, ACS nano.

[39]  T. A. Taton,et al.  Magnetomicelles: composite nanostructures from magnetic nanoparticles and cross-linked amphiphilic block copolymers. , 2005, Nano letters.

[40]  X. Jing,et al.  Biodegradable polymer - cisplatin(IV) conjugate as a pro-drug of cisplatin(II). , 2011, Biomaterials.

[41]  R. Marchessault,et al.  Polyester-based micelles and nanoparticles for the parenteral delivery of taxanes. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[42]  Jun Lin,et al.  Electrospinning Preparation and Drug‐Delivery Properties of an Up‐conversion Luminescent Porous NaYF4:Yb3+, Er3+@Silica Fiber Nanocomposite , 2011 .

[43]  Yong Zhang,et al.  Small upconverting fluorescent nanoparticles for biomedical applications. , 2010, Small.

[44]  Huan-Cheng Chang,et al.  In vivo imaging and toxicity assessments of fluorescent nanodiamonds in Caenorhabditis elegans. , 2010, Nano letters.

[45]  Xiaogang Liu,et al.  Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals. , 2009, Chemical Society reviews.

[46]  F. Auzel.  Upconversion and anti-Stokes processes with f and d ions in solids. , 2004, Chemical reviews.

[47]  Xuesi Chen,et al.  A novel polymer-paclitaxel conjugate based on amphiphilic triblock copolymer. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[48]  S. Brenner.  The genetics of Caenorhabditis elegans. , 1974, Genetics.

[49]  Gregory S Harms,et al.  Upconverting nanoparticles for nanoscale thermometry. , 2011, Angewandte Chemie.

[50]  M. Gottesman,et al.  The role of cellular accumulation in determining sensitivity to platinum-based chemotherapy. , 2008, Annual review of pharmacology and toxicology.

[51]  Jun Lin,et al.  Up‐Conversion Luminescent and Porous NaYF4:Yb3+, Er3+@SiO2 Nanocomposite Fibers for Anti‐Cancer Drug Delivery and Cell Imaging , 2012 .

[52]  X. Jing,et al.  Comparative study of paclitaxel physically encapsulated in and chemically conjugated with PEG-PLA , 2009 .

[53]  Yang Yang,et al.  Long-term in vivo biodistribution imaging and toxicity of polyacrylic acid-coated upconversion nanophosphors. , 2010, Biomaterials.

[54]  Fuyou Li,et al.  High contrast upconversion luminescence targeted imaging in vivo using peptide-labeled nanophosphors. , 2009, Analytical chemistry.

[55]  Phillip L. Williams,et al.  Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology , 2008, Toxicological sciences : an official journal of the Society of Toxicology.

[56]  T. A. Taton,et al.  Core/Shell gold nanoparticles by self-assembly and crosslinking of micellar, block-copolymer shells. , 2005, Angewandte Chemie.

[57]  M. Raff,et al.  Programmed Cell Death in Animal Development , 1997, Cell.