Applications of the catheter-tip electromagnetic velocity probe in the study of the central circulation in man.

Phasic and mean blood flow velocities and pressures were continuously recorded within the venae cavae, pulmonary artery and ascending aorta with a catheter-tip electromagnetic velocity probe in twenty-three conscious patients. During the Valsalva maneuver, following the initial rise in the aorta, blood flow velocity diminished and, after release, increased above normal in all great vessels. In atrial fibrillation, peak aortic and pulmonary arterial velocities varied directly with the length of the preceding cardiac cycle and ventricular end-diastolic pressure. Peak aortic velocity rose markedly following premature ventricular contraction. Leg exercise, isoproterenol and glucagon caused striking elevations of aortic and pulmonary arterial velocities. Thus, this flowmeter catheter allows accurate, rapid and safe measurement of instantaneous linear blood flow and pressures in great vessels of intact patients in the assessment of cardiovascular function.

[1]  D. E. Cobb,et al.  Idiopathic Hypertrophic Subaortic Stenosis: III. Intraoperative Studies of the Mechanism of Obstruction and Its Hemodynamic Consequences , 1964 .

[2]  J. Ross,et al.  Electroaugmentation of Ventricular Performance and Oxygen Consumption by Repetitive Application of Paired Electrical Stimuli , 1965, Circulation research.

[3]  R. Gorlin,et al.  Clinical test for pulmonary congestion with use of the Valsalva maneuver. , 1956, Journal of the American Medical Association.

[4]  G. S. Makin,et al.  Velocity of Blood Flow in Normal Human Venae Cavae , 1968 .

[5]  J. Shillingford,et al.  A Catheter Tip Electromagnetic Velocity Probe and its Evaluation , 1967 .

[6]  D T Mason,et al.  Measurement of Instantaneous Blood Flow Velocity and Pressure in Conscious Man with a Catheter‐Tip Velocity Probe , 1969, Circulation.

[7]  C J Mills,et al.  A catheter tip electromagnetic velocity probe. , 1966, Physics in medicine and biology.

[8]  M. Spencer,et al.  Dynamics of the Normal Aorta: “Inertiance” and “Compliance” of the Arterial System Which Transforms the Cardiac Ejection Pulse , 1958, Circulation research.

[9]  J. Greenfield,et al.  The technique of estimating the instantaneous aortic blood velocity in man from the pressure gradient. , 1961, American heart journal.

[10]  D T Mason,et al.  Patterns of Brachial Arterial Blood Flow in Conscious Human Subjects with and without Cardiac Dysfunction , 1966, Circulation.

[11]  R. F. Whelan,et al.  Reflex Changes in Human Skeletal Muscle Blood Flow Associated with Intrathoracic Pressure Changes , 1958, Circulation research.

[12]  Andrew S. Wechsler,et al.  Relief of Angina Pectoris by Electrical Stimulation of the Carotid-Sinus Nerves , 1967 .

[13]  S. Sarnoff,et al.  Mechanism of the arterial pressure response to the Valsalva test; the basis for its use as an indicator of the intactness of the sympathetic outflow. , 1948, The American journal of physiology.

[14]  J. Greenfield,et al.  PRESSURE-FLOW STUDIES IN HYPERTROPHIC SUBAORTIC STENOSIS. , 1964, The Journal of clinical investigation.

[15]  J. Ross,et al.  Studies on Starling's Law of the Heart: IX. The Effects of Impeding Venous Return on Performance of the Normal and Failing Human Left Ventricle , 1964, Circulation.

[16]  E. Braunwald,et al.  Idiopathic Hypertrophic Subaortic Stenosis: Clinical Analysis of 126 Patients with Emphasis on the Natural History , 1968, Circulation.

[17]  D. E. Cobb,et al.  Direct Determinations of Aortic Blood Flow in Patients with Aortic Regurgitation: Effects of Alterations in Heart Rate, Increased Ventricular Preload or Afterload, and Isoproterenol , 1967, Circulation.

[18]  E. Sonnenblick,et al.  Editorial: Paired Electrical Stimulation of the Heart A Physiologic Riddle and a Clinical Challenge , 1965, Circulation.

[19]  E. Braunwald,et al.  STUDIES ON STARLING'S LAW OF THE HEART. III. OBSERVATIONS IN PATIENTS WITH MITRAL STENOSIS AND ATRIAL FIBRILLATION ON THE RELATIONSHIPS BETWEEN LEFT VENTRICULAR END-DIASTOLIC SEGMENT LENGTH, FILLING PRESSURE, AND THE CHARACTERISTICS OF VENTRICULAR CONTRACTION. , 1960, The Journal of clinical investigation.

[20]  I. G. Porjé,et al.  Hemodynamic Studies with Differential Pressure Technique , 1961 .

[21]  J. Ross,et al.  Effects of increasing frequency of contraction on the force velocity relation of left ventricle. , 1967, Cardiovascular research.

[22]  W. Parmley,et al.  Glucagon: Its Enhancement of Cardiac Performance in the Cat and Dog and Persistence of its Inotropic Action Despite Beta‐Receptor Blockade with Propranolol , 1968, Circulation research.

[23]  B. Lucchesi Cardiac Actions of Glucagon , 1968, Circulation research.

[24]  D J Patel,et al.  Pressure-flow relationships in the ascending aorta and femoral artery of man. , 1965, Journal of applied physiology.

[25]  W. Parmley,et al.  Cardiovascular effects of glucagon in man. , 1968, The New England journal of medicine.

[26]  D. L. Fry,et al.  A Catheter Tip Method for Measurement of the Instantaneous Aortic Blood Velocity , 1956, Circulation research.