The Neural Cell Adhesion Molecule-Derived (NCAM)-Peptide FG Loop (FGL) Mobilizes Endogenous Neural Stem Cells and Promotes Endogenous Regenerative Capacity after Stroke

[1]  K. Psachoulia,et al.  Oligodendrocyte regeneration: Its significance in myelin replacement and neuroprotection in multiple sclerosis , 2016, Neuropharmacology.

[2]  M. Hoehn,et al.  MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia. , 2016, Biomaterials.

[3]  G. Fink,et al.  Transcranial direct current stimulation accelerates recovery of function, induces neurogenesis and recruits oligodendrocyte precursors in a rat model of stroke , 2016, Experimental Neurology.

[4]  O. Lindvall,et al.  Neurogenesis following Stroke Affecting the Adult Brain. , 2015, Cold Spring Harbor perspectives in biology.

[5]  K. Arai,et al.  Mechanisms of cell–cell interaction in oligodendrogenesis and remyelination after stroke , 2015, Brain Research.

[6]  Jun Chen,et al.  White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke , 2015, Experimental Neurology.

[7]  G. Fink,et al.  Osteopontin mediates survival, proliferation and migration of neural stem cells through the chemokine receptor CXCR4 , 2015, Stem Cell Research & Therapy.

[8]  N. Chen,et al.  Selective modulation of microglia polarization to M2 phenotype for stroke treatment. , 2015, International immunopharmacology.

[9]  Jie Pan,et al.  Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner , 2015, Journal of Neuroinflammation.

[10]  L. Fan,et al.  Strategies for myelin regeneration: lessons learned from development , 2014, Neural regeneration research.

[11]  M. O’Banion,et al.  Neuroinflammation and M2 microglia: the good, the bad, and the inflamed , 2014, Journal of Neuroinflammation.

[12]  G. Fink,et al.  The synthetic NCAM mimetic peptide FGL mobilizes neural stem cells in vitro and in vivo , 2014, Stem Cell Reviews and Reports.

[13]  G. Fink,et al.  Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo , 2014, Stem Cell Research & Therapy.

[14]  T. Ikezu,et al.  Fibroblast Growth Factor-2 Signaling in Neurogenesis and Neurodegeneration , 2014, Journal of Neuroimmune Pharmacology.

[15]  M. Stewart,et al.  Amyloid-Beta Induced CA1 Pyramidal Cell Loss in Young Adult Rats Is Alleviated by Systemic Treatment with FGL, a Neural Cell Adhesion Molecule-Derived Mimetic Peptide , 2013, PloS one.

[16]  Tracy J. Yuen,et al.  M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination , 2013, Nature Neuroscience.

[17]  J. Price,et al.  Human conditionally immortalized neural stem cells improve locomotor function after spinal cord injury in the rat , 2013, Stem Cell Research & Therapy.

[18]  L. McCullough,et al.  Microglia and ischemic stroke: a double-edged sword. , 2013, International journal of physiology, pathophysiology and pharmacology.

[19]  M. Lynch,et al.  The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner , 2013, Neuroscience.

[20]  Y. Loh,et al.  The Molecular Profiles of Neural Stem Cell Niche in the Adult Subventricular Zone , 2012, PloS one.

[21]  R. Leak,et al.  Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia , 2012, Stroke.

[22]  M. Lynch,et al.  An NCAM Mimetic, FGL, Alters Hippocampal Cellular Morphometry in Young Adult (4 Month-Old) Rats , 2012, Neurochemical Research.

[23]  M. Hoehn,et al.  Effects of minocycline on endogenous neural stem cells after experimental stroke , 2012, Neuroscience.

[24]  A. Zechariah,et al.  Transduction of Neural Precursor Cells with TAT‐Heat Shock Protein 70 Chaperone: Therapeutic Potential Against Ischemic Stroke after Intrastriatal and Systemic Transplantation , 2012, Stem cells.

[25]  J. Vukovic,et al.  Microglia Modulate Hippocampal Neural Precursor Activity in Response to Exercise and Aging , 2012, The Journal of Neuroscience.

[26]  Eduardo D. Martín,et al.  Facilitation of AMPA Receptor Synaptic Delivery as a Molecular Mechanism for Cognitive Enhancement , 2012, PLoS biology.

[27]  M. Lynch,et al.  A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus , 2011, Experimental Neurology.

[28]  C. Rampon,et al.  The neural cell adhesion molecule-derived peptide FGL facilitates long-term plasticity in the dentate gyrus in vivo. , 2011, Learning & memory.

[29]  G. Fink,et al.  Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns , 2010, Experimental & Translational Stroke Medicine.

[30]  V. Berezin,et al.  The fibroblast growth factor receptor (FGFR) agonist FGF1 and the neural cell adhesion molecule‐derived peptide FGL activate FGFR substrate 2α differently , 2010, Journal of neuroscience research.

[31]  G. Fink,et al.  Noninvasive Imaging of Endogenous Neural Stem Cell Mobilization In Vivo Using Positron Emission Tomography , 2010, The Journal of Neuroscience.

[32]  M. Lynch,et al.  A novel anti-inflammatory role of NCAM-derived mimetic peptide, FGL , 2010, Neurobiology of Aging.

[33]  Deric M. Park,et al.  Targeting neural precursors in the adult brain rescues injured dopamine neurons , 2009, Proceedings of the National Academy of Sciences.

[34]  G. Comi,et al.  Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. , 2009, Brain : a journal of neurology.

[35]  M. Lynch,et al.  A synthetic NCAM‐derived mimetic peptide, FGL, exerts anti‐inflammatory properties via IGF‐1 and interferon‐γ modulation , 2009, Journal of neurochemistry.

[36]  Gereon R Fink,et al.  Neuroinflammation Extends Brain Tissue at Risk to Vital Peri-Infarct Tissue: A Double Tracer [11C]PK11195- and [18F]FDG-PET Study , 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[37]  M. Chopp,et al.  Mechanisms underlying improved recovery of neurological function after stroke in the rodent after treatment with neurorestorative cell-based therapies. , 2009, Stroke.

[38]  M. Chopp,et al.  Ischemic stroke and neurogenesis in the subventricular zone , 2008, Neuropharmacology.

[39]  B. Pakkenberg,et al.  A neural cell adhesion molecule–derived peptide reduces neuropathological signs and cognitive impairment induced by Aβ25-35 , 2007, Neuroscience.

[40]  W. Heiss,et al.  Imaging-guided gene therapy of experimental gliomas. , 2007, Cancer research.

[41]  V. Berezin,et al.  A neural cell adhesion molecule–derived fibroblast growth factor receptor agonist, the FGL-peptide, promotes early postnatal sensorimotor development and enhances social memory retention , 2006, Neuroscience.

[42]  M. Elvers,et al.  Tumor necrosis factor α triggers proliferation of adult neural stem cells via IKK/NF-κB signaling , 2006, BMC Neuroscience.

[43]  Daniel J. Hoeppner,et al.  Notch signalling regulates stem cell numbers in vitro and in vivo , 2006, Nature.

[44]  V. Berezin,et al.  A synthetic NCAM‐derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo , 2005, The European journal of neuroscience.

[45]  Jürgen Winkler,et al.  Doublecortin expression levels in adult brain reflect neurogenesis , 2005, The European journal of neuroscience.

[46]  Silvano Sozzani,et al.  The chemokine system in diverse forms of macrophage activation and polarization. , 2004, Trends in immunology.

[47]  Claus Christensen,et al.  An NCAM‐derived FGF‐receptor agonist, the FGL‐peptide, induces neurite outgrowth and neuronal survival in primary rat neurons , 2004, Journal of neurochemistry.

[48]  A. Shetty,et al.  Efficacy of doublecortin as a marker to analyse the absolute number anddendritic growth of newly generated neurons in the adult dentate gyrus , 2004, The European journal of neuroscience.

[49]  Elisabeth Bock,et al.  Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP. , 2003, Structure.

[50]  D. van der Kooy,et al.  In vivo infusions of exogenous growth factors into the fourth ventricle of the adult mouse brain increase the proliferation of neural progenitors around the fourth ventricle and the central canal of the spinal cord , 2002, The European journal of neuroscience.

[51]  O. Lindvall,et al.  Neuronal replacement from endogenous precursors in the adult brain after stroke , 2002, Nature Medicine.

[52]  Hirofumi Nakatomi,et al.  Regeneration of Hippocampal Pyramidal Neurons after Ischemic Brain Injury by Recruitment of Endogenous Neural Progenitors , 2002, Cell.

[53]  E. Bock,et al.  The neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system , 1998, Experimental Gerontology.

[54]  Michael Schroeter,et al.  Inflammation and glial responses in ischemic brain lesions , 1998, Progress in Neurobiology.

[55]  F R Sharp,et al.  Increased Neurogenesis in the Dentate Gyrus After Transient Global Ischemia in Gerbils , 1998, The Journal of Neuroscience.

[56]  Regina C. Armstrong,et al.  White matter involvement after TBI: Clues to axon and myelin repair capacity , 2016, Experimental Neurology.

[57]  R. Traystman.  Stem Cell Research in Stroke How Far From the Clinic ? , 2011 .

[58]  B. Pakkenberg,et al.  A neural cell adhesion molecule-derived peptide reduces neuropathological signs and cognitive impairment induced by Abeta25-35. , 2007, Neuroscience.