Cell Migration in Microfluidic Devices: Invadosomes Formation in Confined Environments.

[1]  C. Chou,et al.  Nanofluidic fluorescence microscopy with integrated concentration gradient generation for one-shot parallel kinetic assays , 2018, Sensors and Actuators B: Chemical.

[2]  P. Paul-Gilloteaux,et al.  LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration , 2018, Nature Communications.

[3]  L. Sander,et al.  Stiffness Sensing and Cell Motility: Durotaxis and Contact Guidance , 2018, bioRxiv.

[4]  Sharon Evans,et al.  Intravital microscopy in the study of the tumor microenvironment: from bench to human application , 2018, Oncotarget.

[5]  K. Stroka,et al.  Physical confinement alters cytoskeletal contributions towards human mesenchymal stem cell migration , 2018, Cytoskeleton.

[6]  Anaïs Bouissou,et al.  Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking , 2018, Nature Communications.

[7]  S. Courtneidge,et al.  Invadosomes are coming: new insights into function and disease relevance , 2018, The FEBS journal.

[8]  A. Evstrapov.  Micro- and nanofluidic systems in devices for biological, medical and environmental research , 2017 .

[9]  J. Wong,et al.  Extracellular matrix type modulates cell migration on mechanical gradients , 2017, Experimental cell research.

[10]  Richard M Maceiczyk,et al.  Small but Perfectly Formed? Successes, Challenges, and Opportunities for Microfluidics in the Chemical and Biological Sciences , 2017 .

[11]  Chia-Fu Chou,et al.  10 nm deep, sub-nanoliter fluidic nanochannels on germanium for attenuated total reflection infrared (ATR-IR) spectroscopy. , 2017, The Analyst.

[12]  Roger D Kamm,et al.  Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways. , 2016, Cancer research.

[13]  P. Chavrier,et al.  Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion. , 2016, Annual review of cell and developmental biology.

[14]  Pirjo Spuul,et al.  VEGF-A/Notch-Induced Podosomes Proteolyse Basement Membrane Collagen-IV during Retinal Sprouting Angiogenesis. , 2016, Cell reports.

[15]  V. Weaver,et al.  Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease. , 2016, Trends in cell biology.

[16]  Pirjo Spuul,et al.  VEGF-A stimulates podosome-mediated collagen-IV proteolysis in microvascular endothelial cells , 2016, Journal of Cell Science.

[17]  K. Jalink,et al.  Invadosomes - shaping actin networks to follow mechanical cues. , 2016, Frontiers in bioscience.

[18]  C. Chou,et al.  High aspect ratio nanoimprinted grooves of poly(lactic-co-glycolic acid) control the length and direction of retraction fibers during fibroblast cell division. , 2015, Biointerphases.

[19]  Pirjo Spuul,et al.  Microfluidic devices for the study of actin cytoskeleton in constricted environments: Evidence for podosome formation in endothelial cells exposed to a confined slit. , 2015, Methods.

[20]  Pirjo Spuul,et al.  Podosomes: Multipurpose organelles? , 2015, The international journal of biochemistry & cell biology.

[21]  Hans-Günther Machens,et al.  Hydrogels for Engineering of Perfusable Vascular Networks , 2015, International journal of molecular sciences.

[22]  E. Kuhl,et al.  Mechanical properties of gray and white matter brain tissue by indentation. , 2015, Journal of the mechanical behavior of biomedical materials.

[23]  L. Primo,et al.  Podosomes and invadopodia: tools to breach vascular basement membrane , 2015, Cell cycle.

[24]  Wan-Ju Li,et al.  Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression , 2015, Organogenesis.

[25]  J M García-Aznar,et al.  Inducing chemotactic and haptotactic cues in microfluidic devices for three-dimensional in vitro assays. , 2014, Biomicrofluidics.

[26]  E. Génot,et al.  Invadosomes in their natural habitat. , 2014, European journal of cell biology.

[27]  Giuseppe Gigli,et al.  Influence of electrotaxis on cell behaviour. , 2014, Integrative biology : quantitative biosciences from nano to macro.

[28]  C. Chou,et al.  Direct optical mapping of transcription factor binding sites on field-stretched λ-DNA in nanofluidic devices , 2014, Nucleic acids research.

[29]  Pirjo Spuul,et al.  Importance of RhoGTPases in formation, characteristics, and functions of invadosomes , 2014, Small GTPases.

[30]  D. Beebe,et al.  The present and future role of microfluidics in biomedical research , 2014, Nature.

[31]  A. Bershadsky,et al.  Integrin-Matrix Clusters Form Podosome-like Adhesions in the Absence of Traction Forces , 2013, Cell reports.

[32]  Ben Fabry,et al.  Cell and tissue mechanics in cell migration. , 2013, Experimental cell research.

[33]  Pere Roca-Cusachs,et al.  Mechanical guidance of cell migration: lessons from chemotaxis. , 2013, Current opinion in cell biology.

[34]  Robert M. Hoffman,et al.  Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force , 2013, The Journal of cell biology.

[35]  F. Lin,et al.  Recent developments in microfluidics-based chemotaxis studies. , 2013, Lab on a chip.

[36]  A. Woolley,et al.  Advances in microfluidic materials, functions, integration, and applications. , 2013, Chemical reviews.

[37]  Yan Wang,et al.  Study on Invadopodia Formation for Lung Carcinoma Invasion with a Microfluidic 3D Culture Device , 2013, PloS one.

[38]  C. Figdor,et al.  Interplay between myosin IIA-mediated contractility and actin network integrity orchestrates podosome composition and oscillations , 2013, Nature Communications.

[39]  A. Sporbert,et al.  High-Resolution Intravital Microscopy , 2012, PloS one.

[40]  Rachelle N. Palchesko,et al.  Development of Polydimethylsiloxane Substrates with Tunable Elastic Modulus to Study Cell Mechanobiology in Muscle and Nerve , 2012, PloS one.

[41]  C. Chou,et al.  Nanofiber size-dependent sensitivity of fibroblast directionality to the methodology for scaffold alignment. , 2012, Acta biomaterialia.

[42]  R. Weigert,et al.  Intravital microscopy , 2012, Bioarchitecture.

[43]  Sangyoon J. Han,et al.  Decoupling substrate stiffness, spread area, and micropost density: a close spatial relationship between traction forces and focal adhesions. , 2012, Biophysical journal.

[44]  Chia-Fu Chou,et al.  Nanoscale molecular traps and dams for ultrafast protein enrichment in high-conductivity buffers. , 2012, Journal of the American Chemical Society.

[45]  Francis Lin,et al.  Microfluidic device for studying cell migration in single or co-existing chemical gradients and electric fields. , 2012, Biomicrofluidics.

[46]  Ben Fabry,et al.  3D Traction Forces in Cancer Cell Invasion , 2012, PloS one.

[47]  David Beebe,et al.  Engineers are from PDMS-land, Biologists are from Polystyrenia. , 2012, Lab on a chip.

[48]  Pirjo Spuul,et al.  Helicobacter infection induces podosome assembly in primary hepatocytes in vitro. , 2012, European journal of cell biology.

[49]  C. Chou,et al.  Entropy-driven single molecule tug-of-war of DNA at micro-nanofluidic interfaces. , 2012, Nano letters.

[50]  D. Marshall,et al.  Microfluidics for single cell analysis. , 2012, Current opinion in biotechnology.

[51]  T. Reh,et al.  Guiding the morphogenesis of dissociated newborn mouse retinal cells and hES cell-derived retinal cells by soft lithography-patterned microchannel PLGA scaffolds. , 2012, Biomaterials.

[52]  Woo Y. Lee,et al.  Microfluidic 3D bone tissue model for high-throughput evaluation of wound-healing and infection-preventing biomaterials. , 2012, Biomaterials.

[53]  C. Billottet,et al.  Physiological type I collagen organization induces the formation of a novel class of linear invadosomes , 2012, Molecular biology of the cell.

[54]  C. Chou,et al.  Biosensor-compatible encapsulation for pre-functionalized nanofluidic channels using asymmetric plasma treatment , 2012 .

[55]  E. J. Luna,et al.  Supervillin couples myosin-dependent contractility to podosomes and enables their turnover , 2012, Journal of Cell Science.

[56]  R. Díez-Ahedo,et al.  Geometry sensing by dendritic cells dictates spatial organization and PGE2-induced dissolution of podosomes , 2011, Cellular and Molecular Life Sciences.

[57]  M. Geissler,et al.  3D thermoplastic elastomer microfluidic devices for biological probe immobilization. , 2011, Lab on a chip.

[58]  J. Fredberg,et al.  Plithotaxis and emergent dynamics in collective cellular migration. , 2011, Trends in cell biology.

[59]  Francis Lin,et al.  Microfluidic devices for studying chemotaxis and electrotaxis. , 2011, Trends in cell biology.

[60]  Adam T Woolley,et al.  Single-monomer formulation of polymerized polyethylene glycol diacrylate as a nonadsorptive material for microfluidics. , 2011, Analytical chemistry.

[61]  Liviu Nicu,et al.  A dielectrophoretic continuous flow sorter using integrated microelectrodes coupled to a channel constriction , 2011, Electrophoresis.

[62]  Wen Dai,et al.  Whole-Teflon microfluidic chips , 2011, Proceedings of the National Academy of Sciences.

[63]  Y. Eishi,et al.  Localization of the Invadopodia-Related Proteins Actinin-1 and Cortactin to Matrix-Contact-Side Cytoplasm of Cancer Cells in Surgically Resected Lung Adenocarcinomas , 2011, Pathobiology.

[64]  B. Fabry,et al.  Nonlinear viscoelasticity of adherent cells is controlled by cytoskeletal tension , 2011 .

[65]  Sean X. Sun,et al.  Adhesion dynamics and durotaxis in migrating cells , 2011, Physical biology.

[66]  Chia-Fu Chou,et al.  Asymmetric cancer-cell filopodium growth induced by electric-fields in a microfluidic culture chip. , 2011, Lab on a chip.

[67]  Leslie Y Yeo,et al.  Microfluidic devices for bioapplications. , 2011, Small.

[68]  Shuvo Roy,et al.  Anti-biofouling Sulfobetaine Polymer Thin Films on Silicon and Silicon Nanopore Membranes , 2011, Journal of biomaterials science. Polymer edition.

[69]  J. Fredberg,et al.  Collective cell guidance by cooperative intercellular forces , 2010, Nature materials.

[70]  Francis Barany,et al.  Ligase detection reaction generation of reverse molecular beacons for near real-time analysis of bacterial pathogens using single-pair fluorescence resonance energy transfer and a cyclic olefin copolymer microfluidic chip. , 2010, Analytical chemistry.

[71]  N. Jeon,et al.  Biological applications of microfluidic gradient devices. , 2010, Integrative biology : quantitative biosciences from nano to macro.

[72]  Nam-Trung Nguyen,et al.  Oxygen plasma treatment for reducing hydrophobicity of a sealed polydimethylsiloxane microchannel. , 2010, Biomicrofluidics.

[73]  Joong Yull Park,et al.  Increased poly(dimethylsiloxane) stiffness improves viability and morphology of mouse fibroblast cells , 2010 .

[74]  Martin A. Schwartz,et al.  Cell adhesion: integrating cytoskeletal dynamics and cellular tension , 2010, Nature Reviews Molecular Cell Biology.

[75]  A. Levchenko,et al.  Simple haptotactic gradient generation within a triangular microfluidic channel. , 2010, Lab on a chip.

[76]  D. Irimia.  Microfluidic technologies for temporal perturbations of chemotaxis. , 2010, Annual review of biomedical engineering.

[77]  R. Zare,et al.  Microfluidic platforms for single-cell analysis. , 2010, Annual review of biomedical engineering.

[78]  B. Kirby.  Micro- and nanoscale fluid mechanics : transport in microfluidic devices , 2010 .

[79]  Cheng-han Yu,et al.  Engineering supported membranes for cell biology , 2010, Medical & Biological Engineering & Computing.

[80]  A. Prescott,et al.  Dendritic cell podosomes are protrusive and invade the extracellular matrix using metalloproteinase MMP-14 , 2010, Journal of Cell Science.

[81]  D. Beebe,et al.  Fundamentals of microfluidic cell culture in controlled microenvironments. , 2010, Chemical Society reviews.

[82]  Matthieu Piel,et al.  Microfluidic tools for cell biological research. , 2010, Nano today.

[83]  C. Billottet,et al.  TGFβ-induced endothelial podosomes mediate basement membrane collagen degradation in arterial vessels , 2009, Journal of Cell Science.

[84]  Chia-Fu Chou,et al.  Enhancing DNA hybridization kinetics through constriction-based dielectrophoresis. , 2009, Lab on a chip.

[85]  Hsueh-Chia Chang,et al.  Electrokinetically-Driven Microfluidics and Nanofluidics , 2009 .

[86]  Mehmet Toner,et al.  Spontaneous migration of cancer cells under conditions of mechanical confinement. , 2009, Integrative biology : quantitative biosciences from nano to macro.

[87]  Anthony Atala,et al.  Tissue-specific extracellular matrix coatings for the promotion of cell proliferation and maintenance of cell phenotype. , 2009, Biomaterials.

[88]  David A. Weitz,et al.  Physical forces during collective cell migration , 2009 .

[89]  Benoit Ladoux,et al.  Biophysics: Cells guided on their journey , 2009 .

[90]  Arul Jayaraman,et al.  Flow-Based Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable, Competing Gradients , 2009, Applied and Environmental Microbiology.

[91]  David S. Harburger,et al.  Integrin signalling at a glance , 2009, Journal of Cell Science.

[92]  Scott A. Guelcher,et al.  Extracellular Matrix Rigidity Promotes Invadopodia Activity , 2008, Current Biology.

[93]  S. Ellis,et al.  Influence of supramammary lymph node extract on in vitro cell proliferation , 2008, Cell proliferation.

[94]  Min Cheol Park,et al.  Soft lithography for microfluidics: a review , 2008 .

[95]  R. McClelland,et al.  Gradients in the liver's extracellular matrix chemistry from periportal to pericentral zones: influence on human hepatic progenitors. , 2008, Tissue engineering. Part A.

[96]  C. Chou,et al.  A simple polysilsesquioxane sealing of nanofluidic channels below 10 nm at room temperature. , 2007, Lab on a chip.

[97]  S. Linder.  The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. , 2007, Trends in cell biology.

[98]  L. Addadi,et al.  The Architecture of the Adhesive Apparatus of Cultured Osteoclasts: From Podosome Formation to Sealing Zone Assembly , 2007, PloS one.

[99]  Ali Khademhosseini,et al.  Fabrication of non-biofouling polyethylene glycol micro- and nanochannels by ultraviolet-assisted irreversible sealing. , 2006, Lab on a chip.

[100]  M. Toner,et al.  Universal microfluidic gradient generator. , 2006, Analytical chemistry.

[101]  P. Tracqui,et al.  Spatiotemporal dynamics of actin-rich adhesion microdomains: influence of substrate flexibility , 2006, Journal of Cell Science.

[102]  E. Génot,et al.  Transforming Growth Factor β Induces Rosettes of Podosomes in Primary Aortic Endothelial Cells , 2006, Molecular and Cellular Biology.

[103]  M. Sheetz,et al.  Local force and geometry sensing regulate cell functions , 2006, Nature Reviews Molecular Cell Biology.

[104]  P. Janmey,et al.  Tissue Cells Feel and Respond to the Stiffness of Their Substrate , 2005, Science.

[105]  Dorian Liepmann,et al.  Effects of shear stress on endothelial cell haptotaxis on micropatterned surfaces. , 2005, Biochemical and biophysical research communications.

[106]  Min Zhao,et al.  Controlling cell behavior electrically: current views and future potential. , 2005, Physiological reviews.

[107]  Qiaobing Xu,et al.  A general method for patterning gradients of biomolecules on surfaces using microfluidic networks. , 2005, Analytical chemistry.

[108]  Xingyu Jiang,et al.  Directing cell migration with asymmetric micropatterns. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[109]  A S G Curtis,et al.  Morphological and microarray analysis of human fibroblasts cultured on nanocolumns produced by colloidal lithography. , 2005, European cells & materials.

[110]  P. Devreotes,et al.  Chemotaxis: signalling the way forward , 2004, Nature Reviews Molecular Cell Biology.

[111]  Ueli Aebi,et al.  Dynamic elastic modulus of porcine articular cartilage determined at two different levels of tissue organization by indentation-type atomic force microscopy. , 2004, Biophysical journal.

[112]  G. Borisy,et al.  Cell Migration: Integrating Signals from Front to Back , 2003, Science.

[113]  G. Whitesides,et al.  Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices. , 2003, Analytical chemistry.

[114]  Aaron R Wheeler,et al.  Microfluidic device for single-cell analysis. , 2003, Analytical chemistry.

[115]  Christopher S. Chen,et al.  Cells lying on a bed of microneedles: An approach to isolate mechanical force , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[116]  N. Abbott,et al.  Fabrication of polymeric substrates with well-defined nanometer-scale topography and tailored surface chemistry , 2002 .

[117]  G. Whitesides,et al.  Poly(dimethylsiloxane) as a material for fabricating microfluidic devices. , 2002, Accounts of chemical research.

[118]  D. Stamenović,et al.  Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells. , 2002, American journal of physiology. Cell physiology.

[119]  D. Ingber,et al.  Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins , 2002, Science's STKE.

[120]  David Juncker,et al.  Formation of gradients of proteins on surfaces with microfluidic networks , 2000 .

[121]  M. Dembo,et al.  Cell movement is guided by the rigidity of the substrate. , 2000, Biophysical journal.

[122]  S. A. Stern,et al.  Diffusion of Gases in Silicone Polymers: Molecular Dynamics Simulations , 1998 .

[123]  Y. Wang,et al.  Cell locomotion and focal adhesions are regulated by the mechanical properties of the substrate. , 1998, The Biological bulletin.

[124]  Heidi E. Hamm,et al.  The Many Faces of G Protein Signaling* , 1998, The Journal of Biological Chemistry.

[125]  D. Lauffenburger,et al.  Cell Migration: A Physically Integrated Molecular Process , 1996, Cell.

[126]  Jens Anders Branebjerg,et al.  Microfluidics-a review , 1993 .

[127]  K R Robinson,et al.  The responses of cells to electrical fields: a review , 1985, The Journal of cell biology.

[128]  S. Carter,et al.  Haptotaxis and the Mechanism of Cell Motility , 1967, Nature.

[129]  A. Hill.  The heat of shortening and the dynamic constants of muscle , 1938 .

[130]  S. Linder,et al.  Tools of the trade: podosomes as multipurpose organelles of monocytic cells , 2014, Cellular and Molecular Life Sciences.

[131]  Christine Unger,et al.  In vitro cell migration and invasion assays. , 2013, Mutation research.

[132]  G. Whitesides,et al.  Diagnostics for the developing world: microfluidic paper-based analytical devices. , 2010, Analytical chemistry.

[133]  B. Kirby.  Micro- and Nanoscale Fluid Mechanics by Brian J. Kirby , 2010 .

[134]  Jennifer L. West,et al.  Synthetic Materials in the Study of Cell Response to Substrate Rigidity , 2009, Annals of Biomedical Engineering.

[135]  B. Geiger,et al.  Environmental sensing through focal adhesions , 2009, Nature Reviews Molecular Cell Biology.

[136]  W. Tian,et al.  Introduction to Microfluidics , 2008 .

[137]  A. Folch,et al.  Biomolecular gradients in cell culture systems. , 2008, Lab on a chip.

[138]  T. Sawai,et al.  The role of heparin-binding EGF-like growth factor and amphiregulin in the epidermal proliferation of psoriasis in cooperation with TNFα , 2007, Archives of Dermatological Research.

[139]  J. Kennedy,et al.  Novel polyisobutylene/polydimethylsiloxane bicomponent networks: III. Tissue compatibility. , 1999, Journal of biomaterials science. Polymer edition.

[140]  Andreas Deutsch,et al.  Dynamics of cell and tissue motion , 1997 .

[141]  A. Gilman,et al.  G proteins. , 1992, Scientific American.

[142]  A. Manz,et al.  Miniaturized total chemical analysis systems: A novel concept for chemical sensing , 1990 .