INFLAMMATION AND ALZHEIMERS DISEASE

[1]  Virginia M. Y. Lee,et al.  Complement activation by neurofibrillary tangles in Alzheimer's disease , 2001, Neuroscience Letters.

[2]  J. Rogers,et al.  Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons. , 1999, Journal of neuropathology and experimental neurology.

[3]  R. Veerhuis,et al.  Cytokines Associated with Amyloid Plaques in Alzheimer's Disease Brain Stimulate Human Glial and Neuronal Cell Cultures to Secrete Early Complement Proteins, But Not C1-Inhibitor , 1999, Experimental Neurology.

[4]  B. Fiebich,et al.  Interleukin‐6 Activates Signal Transducer and Activator of Transcription and Mitogen‐Activated Protein Kinase Signal Transduction Pathways and Induces De Novo Protein Synthesis in Human Neuronal Cells , 1999, Journal of neurochemistry.

[5]  K. Pennypacker,et al.  Effect of dexamethasone on elevated cytokine mRNA levels in chemical‐induced hippocampal injury , 1999, Journal of neuroscience research.

[6]  J. Bauer,et al.  The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and alphal-anti-chymotrypsin synthesis in astrocytes by preventing degradation of IκB-alpha , 1999, Neuropharmacology.

[7]  L. Lue,et al.  Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer’s Disease , 1999 .

[8]  G. Pasinetti,et al.  Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2. , 1999, The American journal of pathology.

[9]  M. Gold,et al.  The alpha-2 macroglobulin gene is not associated with Alzheimer's disease in a case-control sample , 1999, Neuroscience Letters.

[10]  Yogesh K. Dwivedi,et al.  Glucocorticoids Stimulate Inflammatory 5‐Lipoxygenase Gene Expression and Protein Translocation in the Brain , 1999, Journal of neurochemistry.

[11]  P. Aisen,et al.  Regional distribution of cyclooxygenase‐2 in the hippocampal formation in Alzheimer's disease , 1999, Journal of neuroscience research.

[12]  R. Motter,et al.  Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse , 1999, Nature.

[13]  J. Crowley,et al.  The myeloperoxidase system of human phagocytes generates Nepsilon-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation. , 1999, The Journal of clinical investigation.

[14]  S. Wiese,et al.  Developmental Requirement of gp130 Signaling in Neuronal Survival and Astrocyte Differentiation , 1999, The Journal of Neuroscience.

[15]  F. Poulsen,et al.  Dexamethasone selectively suppresses microglial trophic responses to hippocampal deafferentation , 1999, Neuroscience.

[16]  S. Hazen,et al.  Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro. , 1999, The Journal of clinical investigation.

[17]  B. Sommer,et al.  Association of microglia with amyloid plaques in brains of APP23 transgenic mice. , 1999, The American journal of pathology.

[18]  P. Aisen,et al.  Complement‐derived anaphylatoxin C5a protects against glutamate‐mediated neurotoxicity , 1999, Journal of cellular biochemistry.

[19]  Schumann,et al.  Anti-inflammatory substances - a new therapeutic option in Alzheimer's disease. , 1999, Drug discovery today.

[20]  F. Rossi,et al.  beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease. , 1999, The Journal of biological chemistry.

[21]  P. Richardson,et al.  Nature of the Retrograde Signal from Injured Nerves that Induces Interleukin-6 mRNA in Neurons , 1999, The Journal of Neuroscience.

[22]  C. Sandi,et al.  Opposite effects on NCAM expression in the rat frontal cortex induced by acute vs. chronic corticosterone treatments , 1999, Brain Research.

[23]  N. Davoust,et al.  Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells , 1999, Glia.

[24]  C. Finch,et al.  Glycoprotein 330/Megalin (LRP-2) Has Low Prevalence as mRNA and Protein in Brain Microvessels and Choroid Plexus , 1999, Experimental Neurology.

[25]  N. Fox,et al.  Effects of acute prednisone administration on memory, attention and emotion in healthy human adults , 1999, Psychoneuroendocrinology.

[26]  P. Eikelenboom,et al.  The amino-terminus of the amyloid-β protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages , 1999, Journal of Neuroimmunology.

[27]  A. Fagan,et al.  Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. , 1999, The Journal of clinical investigation.

[28]  C. Finch,et al.  Glial gene expression during aging in rat striatum and in long‐term responses to 6‐OHDA lesions , 1999, Synapse.

[29]  M. Owen,et al.  No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease , 1999, Neuroscience Letters.

[30]  G. Levi,et al.  Down‐regulation of microglial cyclo‐oxygenase‐2 and inducible nitric oxide synthase expression by lipocortin 1 , 1999, British journal of pharmacology.

[31]  T. Morgan,et al.  The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction , 1999, Neuroscience.

[32]  S. Knapp,et al.  Prostaglandin E2 Stimulates Amyloid Precursor Protein Gene Expression: Inhibition by Immunosuppressants , 1999, The Journal of Neuroscience.

[33]  C. Behl Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches , 1999, Progress in Neurobiology.

[34]  W. Streit,et al.  Cytokine transcripts expressed by microglia in vitro are not expressed by ameboid microglia of the developing rat central nervous system , 1999, Glia.

[35]  N. Janabi,et al.  Negative feedback between prostaglandin and alpha- and beta-chemokine synthesis in human microglial cells and astrocytes. , 1999, Journal of immunology.

[36]  G. Landreth,et al.  Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of β-Amyloid and Prion Proteins , 1999, The Journal of Neuroscience.

[37]  E. Masliah,et al.  Myeloperoxidase Polymorphism Is Associated with Gender Specific Risk for Alzheimer's Disease , 1999, Experimental Neurology.

[38]  G. Wilkin,et al.  Expression of COX-2 by Normal and Reactive Astrocytes in the Adult Rat Central Nervous System , 1999, Molecular and Cellular Neuroscience.

[39]  G. Wenk,et al.  Pathological and biochemical consequences of acute and chronic neuroinflammation within the basal forebrain cholinergic system of rats , 1999, Neuroscience.

[40]  P. Gebicke-haerter,et al.  Increased Expression of Cyclooxygenases and Peroxisome Proliferator-Activated Receptor-γ in Alzheimer's Disease Brains , 1999 .

[41]  C. Hawkey,et al.  COX-2 inhibitors , 1999, The Lancet.

[42]  J. Poirier,et al.  The polymorphism in exon 3 of the low density lipoprotein receptor-related protein gene is weakly associated with Alzheimer's disease , 1999, Neuroscience Letters.

[43]  J. Wegiel,et al.  MRI of entorhinal cortex in mild Alzheimer's disease , 1999, The Lancet.

[44]  G. Wenk,et al.  Peripheral administration of novel anti-inflammatories can attenuate the effects of chronic inflammation within the CNS , 1999, Brain Research.

[45]  E. Scarpini,et al.  Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with β-amyloid[25–35] , 1999, Journal of Neuroimmunology.

[46]  W. Markesbery,et al.  Oxidative Alterations in Alzheimer's Disease , 1999, Brain pathology.

[47]  P. Heinrich,et al.  Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses. , 1998, Journal of immunology.

[48]  K. Kataoka,et al.  Differential regulation of microglial activation by propentofylline via cAMP signaling , 1998, Brain Research.

[49]  R. Cacabelos,et al.  Microglial activation induced by factor(s) contained in sera from Alzheimer‐related ApoE genotypes , 1998, Journal of neuroscience research.

[50]  A. Roher,et al.  The HHQK Domain of β-Amyloid Provides a Structural Basis for the Immunopathology of Alzheimer’s Disease* , 1998, The Journal of Biological Chemistry.

[51]  S. Barnum,et al.  Elevated complement C5a receptor expression on neurons and glia in astrocyte‐targeted interleukin‐3 transgenic mice , 1998, Glia.

[52]  F. Bloom,et al.  Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration. , 1998, Journal of immunology.

[53]  G. Wenk,et al.  The neural mechanisms underlying cholinergic celldeath within the basal FOREBRAINfn2 fn2 Thepreparation of this chapter was supported in part by theNational Institute of Aging, RO1 AG10546, and theAlzheimers Association, IIRG-95-004. , 1998, International Journal of Developmental Neuroscience.

[54]  B Horwitz,et al.  Dissociation between corpus callosum atrophy and white matter pathology in Alzheimer's disease , 1998, Neurology.

[55]  J. Kaye,et al.  The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. , 1998, Archives of neurology.

[56]  J Q Trojanowski,et al.  Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. , 1998, The American journal of pathology.

[57]  I. Ferrer,et al.  TrkA immunoreactivity in reactive astrocytes in human neurodegenerative diseases and colchicine-treated rats , 1998, Acta Neuropathologica.

[58]  M. Albert,et al.  Genetic association of an (α2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease , 1998 .

[59]  Karla K Kopec,et al.  Alzheimer's β‐Amyloid Peptide 1–42 Induces a Phagocytic Response in Murine Microglia , 1998, Journal of neurochemistry.

[60]  M. Mattson,et al.  Effects of amyloid precursor protein derivatives andoxidative stress on basal forebrain cholinergic systems inALZHEIMERS disease , 1998, International Journal of Developmental Neuroscience.

[61]  D. Walker,et al.  Expression of complement C4 and C9 genes by human astrocytes , 1998, Brain Research.

[62]  W. Markesbery,et al.  Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation , 1998, The Journal of Neuroscience.

[63]  G. Pasinetti,et al.  Cyclooxygenase and inflammation in Alzheimer's disease: Experimental approaches and clinical interventions , 1998, Journal of neuroscience research.

[64]  C. Plata-salamán,et al.  Modulation of TNF-α mRNA production in rat C6 glioma cells by TNF-α, IL-1β, IL-6, and IFN-α: In vitro analysis of cytokine-cytokine interactions , 1998, Brain Research Bulletin.

[65]  G. Brewer,et al.  Upregulation of amyloid precursor protein gene promoter in rat primary hippocampal neurons by phorbol ester, IL-1 and retinoic acid, but not by reactive oxygen species. , 1998, Brain research. Molecular brain research.

[66]  P. Curtis‐Prior,et al.  Therapeutic Value of Ginkgo biloba in Reducing Symptoms of Decline in Mental Function , 1998, The Journal of pharmacy and pharmacology.

[67]  E. Masliah,et al.  Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor. , 1998, The American journal of pathology.

[68]  P. Isakson,et al.  Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[69]  R. Veerhuis,et al.  Complement C1-inhibitor expression in Alzheimer’s disease , 1998, Acta Neuropathologica.

[70]  P. Aisen,et al.  Induction of cyclooxygenase (COX)-2 but not COX-1 gene expression in apoptotic cell death , 1998, Journal of Neuroimmunology.

[71]  Steven M. Horvath,et al.  Alpha-2 macroglobulin is genetically associated with Alzheimer disease , 1998, Nature Genetics.

[72]  B. Bradt,et al.  Complement-dependent Proinflammatory Properties of the Alzheimer's Disease β-Peptide , 1998, Journal of Experimental Medicine.

[73]  Michael W. Miller,et al.  Transforming Growth Factor β1 Regulates the Expression of Cyclooxygenase in Cultured Cortical Astrocytes and Neurons , 1998 .

[74]  Daniel Bandy,et al.  Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease , 1998, Annals of neurology.

[75]  C. Plata-salamán,et al.  Brain cytokine mRNAs in anorectic rats bearing prostate adenocarcinoma tumor cells. , 1998, The American journal of physiology.

[76]  P. Aisen,et al.  Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain , 1998, Neuroscience.

[77]  J. Demartino,et al.  Binding and Functional Properties of Recombinant and Endogenous CXCR3 Chemokine Receptors* , 1998, The Journal of Biological Chemistry.

[78]  Bruce A. Yankner,et al.  Aging renders the brain vulnerable to amyloid β-protein neurotoxicity , 1998, Nature Medicine.

[79]  B. Hyman,et al.  Immunohistochemical Study of the β-Chemokine Receptors CCR3 and CCR5 and Their Ligands in Normal and Alzheimer's Disease Brains , 1998 .

[80]  T. Erkinjuntti,et al.  Propentofylline in the Treatment of Alzheimer’s Disease and Vascular Dementia: A Review of Phase III Trials , 1998, Dementia and Geriatric Cognitive Disorders.

[81]  K. Ishii,et al.  Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease , 1998, Neurology.

[82]  O. Yoshie,et al.  Identification of Single C Motif-1/Lymphotactin Receptor XCR1* , 1998, The Journal of Biological Chemistry.

[83]  Douglas R. McDonald,et al.  β-Amyloid Fibrils Activate Parallel Mitogen-Activated Protein Kinase Pathways in Microglia and THP1 Monocytes , 1998, The Journal of Neuroscience.

[84]  S. Meri,et al.  Induced expression of neuronal membrane attack complex and cell death by Alzheimer's β-amyloid peptide , 1998, Brain Research.

[85]  S. Paul,et al.  The NF-κB/Rel family of proteins mediates Aβ-induced neurotoxicity and glial activation , 1998 .

[86]  G. Sobue,et al.  Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer’s disease brain , 1998, Acta Neuropathologica.

[87]  D. Walker Expression and regulation of complement C1q by human THP-1-derived macrophages. , 1998, Molecular and chemical neuropathology.

[88]  B. Hyman,et al.  Confirmation of an association between a polymorphism in exon 3 of the low‐density lipoprotein receptor‐related protein gene and Alzheimer's disease , 1998, Neurology.

[89]  T. Morgan,et al.  Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[90]  D. Holtzman,et al.  Nascent Astrocyte Particles Differ from Lipoproteins in CSF , 1998, Journal of neurochemistry.

[91]  R. Majocha,et al.  Indomethacin Reverses the Microglial Response to Amyloid β-Protein , 1998, Neurobiology of Aging.

[92]  N. Shibata,et al.  Inducible nitric oxide synthase (iNOS)-like immunoreactivity in argyrophilic, tau-positive astrocytes in progressive supranuclear palsy , 1998, Acta Neuropathologica.

[93]  P. Gasque,et al.  Expression of the C1q/MBL/SPA receptor involved in phagocytosis and innate immune defense on human glia , 1998 .

[94]  D. Munoz,et al.  Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging , 1998, Neurology.

[95]  Y. Ando,et al.  Histochemical detection of 4-hydroxynonenal protein in Alzheimer amyloid , 1998, Journal of the Neurological Sciences.

[96]  A. M. Szczepanik,et al.  Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor/interleukin-6 complex. , 1998, Brain research. Molecular brain research.

[97]  S. Rose-John,et al.  Sympathetic neurons can produce and respond to interleukin 6. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[98]  O. Khorkova,et al.  α2-macroglobulin associates with β-amyloid peptide and prevents fibril formation , 1998 .

[99]  D. Laskowitz,et al.  Endogenous apolipoprotein E suppresses LPS‐stimulated microglial nitric oxide production , 1998, Neuroreport.

[100]  E. Ling,et al.  Properties of Activated Microglia and Pharmacologic Interference by Propentofylline , 1998, Alzheimer disease and associated disorders.

[101]  S. Paul,et al.  α2‐Macroglobulin Attenuates β‐Amyloid Peptide 1–40 Fibril Formation and Associated Neurotoxicity of Cultured Fetal Rat Cortical Neurons , 1998 .

[102]  J. Yesavage,et al.  Cognitive and Noncognitive Symptoms in Dementia Patients: Relationship to Cortisol and Dehydroepiandrosterone , 1998, International Psychogeriatrics.

[103]  J. Loike,et al.  Microglia, Scavenger Receptors, and the Pathogenesis of Alzheimer’s Disease , 1998, Neurobiology of Aging.

[104]  A. Luster,et al.  Chemokines--chemotactic cytokines that mediate inflammation. , 1998, The New England journal of medicine.

[105]  S. Tsai,et al.  Molecular cloning and characterization of a human brain-specific gene implicated in neuronal differentiation. , 1998, Brain research. Molecular brain research.

[106]  D. Coakley,et al.  Hypothalamic-pituitary-adrenal axis dysfunction in Alzheimer's disease: lack of association between longitudinal and cross-sectional findings. , 1998, The American journal of psychiatry.

[107]  R. Ludwig,et al.  Proteolytic Degradation of Alzheimer's Disease Amyloid β‐Peptide by a Metalloproteinase from Microglia Cells , 1998, Journal of neurochemistry.

[108]  G. Levi,et al.  Opposite regulation of prostaglandin E2 synthesis by transforming growth factor-β1 and interleukin 10 in activated microglial cultures , 1998, Journal of Neuroimmunology.

[109]  J. Silver,et al.  Astrocytes Regulate Microglial Phagocytosis of Senile Plaque Cores of Alzheimer's Disease , 1998, Experimental Neurology.

[110]  K. Flanders,et al.  TRANSFORMING GROWTH FACTOR-βS IN NEURODEGENERATIVE DISEASE , 1998, Progress in Neurobiology.

[111]  J. B. Hutchins,et al.  Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction , 1998, The Journal of Neuroscience.

[112]  P. Dobrzanski,et al.  Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease , 1998, Brain Research.

[113]  W. Griffin,et al.  Glial‐Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression , 1998, Brain pathology.

[114]  Christopher K. Glass,et al.  The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation , 1998, Nature.

[115]  J. Pachter,et al.  Suppression of Aβ-induced monocyte neurotoxicity by antiinflammatory compounds , 1997, Journal of Neuroimmunology.

[116]  M. Weiner,et al.  Cortisol Secretion and Alzheimer’s Disease Progression , 1997, Biological Psychiatry.

[117]  Manuel Buttini,et al.  Lipopolysaccharide induces expression of tumour necrosis factor alpha in rat brain: inhibition by methylprednisolone and by rolipram , 1997, British journal of pharmacology.

[118]  C. Finch,et al.  NSAIDS inhibit the IL-1β-induced IL-6 release from human post-mortem astrocytes: the involvement of prostaglandin E2 , 1997, Brain Research.

[119]  C. Colton,et al.  Modulation of nitric oxide production in human macrophages by apolipoprotein-E and amyloid-beta peptide. , 1997, Biochemical and biophysical research communications.

[120]  T. Schall,et al.  Identification and Molecular Characterization of Fractalkine Receptor CX3CR1, which Mediates Both Leukocyte Migration and Adhesion , 1997, Cell.

[121]  F. Maxfield,et al.  Slow Degradation of Aggregates of the Alzheimer’s Disease Amyloid β-Protein by Microglial Cells* , 1997, The Journal of Biological Chemistry.

[122]  C. Cotman,et al.  Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain , 1997, Brain Research.

[123]  Kevin J. Tracey,et al.  Expression of TNF and TNF Receptors (p55 and p75) in the Rat Brain after Focal Cerebral Ischemia , 1997, Molecular medicine.

[124]  A. Coppens,et al.  Cholinergic Neurotransmission Has Different Effects on Cerebral Glucose Consumption and Blood Flow in Young Normals, Aged Normals, and Alzheimer's Disease Patients , 1997, NeuroImage.

[125]  D. Holtzman,et al.  α2‐Macroglobulin Complexes with and Mediates the Endocytosis of β‐Amyloid Peptide via Cell Surface Low‐Density Lipoprotein Receptor‐Related Protein , 1997 .

[126]  Y. Chong Effect of a carboxy-terminal fragment of the Alzheimer's amyloid precursor protein on expression of proinflammatory cytokines in rat glial cells. , 1997, Life sciences.

[127]  L. Mucke,et al.  Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's disease , 1997, Nature.

[128]  H. Yamaguchi,et al.  Microglial activation in early stages of amyloid β protein deposition , 1997, Acta Neuropathologica.

[129]  J. Eder Tumour necrosis factor α and interleukin 1 signalling: do MAPKK kinases connect it all? , 1997 .

[130]  S. Rivest,et al.  Regulation of the Genes Encoding Interleukin‐6, Its Receptor, and gp130 in the Rat Brain in Response to the Immune Activator Lipopolysaccharide and the Proinflammatory Cytokine Interleukin‐1β , 1997, Journal of neurochemistry.

[131]  H Rusinek,et al.  Cortisol reduces hippocampal glucose metabolism in normal elderly, but not in Alzheimer's disease. , 1997, The Journal of clinical endocrinology and metabolism.

[132]  Rena Li,et al.  Neuronal expression of mRNAs for complement proteins of the classical pathway in Alzheimer brain , 1997, Brain Research.

[133]  D. Walker,et al.  Neurons express proteins of the classical complement pathway in Alzheimer disease , 1997, Brain Research.

[134]  C. Masters,et al.  Reactive oxygen species and Alzheimer's disease. , 1997, Biochemical pharmacology.

[135]  C. Colton,et al.  Polyribonucleotides induce nitric oxide production by human monocyte‐derived macrophages , 1997, Journal of leukocyte biology.

[136]  A. Roses,et al.  ApoE, Alzheimer's Disease, and Recovery from Brain Stress a , 1997, Annals of the New York Academy of Sciences.

[137]  Hong Liu,et al.  Endoplasmic Reticulum Chaperones GRP78 and Calreticulin Prevent Oxidative Stress, Ca2+ Disturbances, and Cell Death in Renal Epithelial Cells* , 1997, The Journal of Biological Chemistry.

[138]  S. Barger,et al.  Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E , 1997, Nature.

[139]  O. Wolkowitz,et al.  Glucocorticoid Medication, Memory and Steroid Psychosis in Medical Illness , 1997, Annals of the New York Academy of Sciences.

[140]  J. G. Zhang,et al.  Evidence for the formation of a heterotrimeric complex of leukaemia inhibitory factor with its receptor subunits in solution. , 1997, The Biochemical journal.

[141]  E. Tartour,et al.  Characterization of soluble gp130 released by melanoma cell lines: A polyvalent antagonist of cytokines from the interleukin 6 family. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

[142]  U. Otten,et al.  Interleukin-6 (IL-6)—A molecule with both beneficial and destructive potentials , 1997, Progress in Neurobiology.

[143]  P. Mcgeer,et al.  β‐Amyloid protein enhances macrophage production of oxygen free radicals and glutamate , 1997 .

[144]  R. Dodel,et al.  α2‐Macroglobulin as a β‐Amyloid Peptide‐Binding Plasma Protein , 1997 .

[145]  L. Thal,et al.  Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), and apolipoprotein E receptor, with late-onset Alzheimer's disease , 1997, Neurology.

[146]  J. Rogers,et al.  Aggregation State‐Dependent Activation of the Classical Complement Pathway by the Amyloid β Peptide , 1997, Journal of neurochemistry.

[147]  D. Salvemini Regulation of cyclooxygenase enzymes by nitric oxide , 1997, Cellular and Molecular Life Sciences CMLS.

[148]  L. Lue,et al.  Molecular and Cellular Characterization of the Membrane Attack Complex, C5b-9, in Alzheimer’s Disease , 1997, Neurobiology of Aging.

[149]  L. Steinman Some Misconceptions about Understanding Autoimmunity through Experiments with Knockouts , 1997, The Journal of experimental medicine.

[150]  H. Möller,et al.  Interleukin-6 is not altered in cerebrospinal fluid of first-degree relatives and patients with Alzheimer's disease 1 Paper will be presented in part (Abstract) at the Meeting of the Society for Neuroscience, New Orleans, LA, USA in October 1997. 1 , 1997, Neuroscience Letters.

[151]  D. Laskowitz,et al.  Apolipoprotein E suppresses glial cell secretion of TNFα , 1997, Journal of Neuroimmunology.

[152]  T. Miyakawa,et al.  Identification of monocyte chemoattractant protein‐1 in senile plaques and reactive microglia of Alzheimer's disease , 1997, Psychiatry and clinical neurosciences.

[153]  Y. Persidsky,et al.  Dexamethasone therapy worsens the neuropathology of human immunodeficiency virus type 1 encephalitis in SCID mice. , 1997, The Journal of infectious diseases.

[154]  W. Tourtellotte,et al.  Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[155]  M. Sakanaka,et al.  Glucocorticoid‐ and mineralocorticoid receptors in microglial cells: The two receptors mediate differential effects of corticosteroids , 1997, Glia.

[156]  P Woodbury,et al.  A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. , 1997, The New England journal of medicine.

[157]  M. Ross,et al.  Cyclo-Oxygenase-2 Gene Expression in Neurons Contributes to Ischemic Brain Damage , 1997, The Journal of Neuroscience.

[158]  Joseph S. Beckman,et al.  Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease , 1997, The Journal of Neuroscience.

[159]  Douglas R. McDonald,et al.  Amyloid Fibrils Activate Tyrosine Kinase-Dependent Signaling and Superoxide Production in Microglia , 1997, The Journal of Neuroscience.

[160]  Y. Olsson,et al.  Expression of various TGF-β isoforms and type I receptor in necrotizing human brain lesions , 1997, Acta Neuropathologica.

[161]  P. Baeuerle,et al.  Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease , 1997 .

[162]  X. F. Wang,et al.  Expression of mRNAs coding for the transforming growth factor-beta receptors in brain regions of euthyroid and hypothyroid neonatal rats and in adult brain. , 1997, Brain research. Developmental brain research.

[163]  L. Schweitzer,et al.  Expression of chemokine receptors by subsets of neurons in the central nervous system. , 1997, Journal of immunology.

[164]  D. Selkoe,et al.  Degradation of Amyloid β-Protein by a Metalloprotease Secreted by Microglia and Other Neural and Non-neural Cells* , 1997, The Journal of Biological Chemistry.

[165]  W F Stewart,et al.  Risk of Alzheimer's disease and duration of NSAID use , 1997, Neurology.

[166]  L. Mucke,et al.  Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo , 1997, Neuroscience.

[167]  C. Heyser,et al.  Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[168]  T. Handel,et al.  Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo. , 1997, Journal of immunology.

[169]  Wei Wang,et al.  A new class of membrane-bound chemokine with a CX3C motif , 1997, Nature.

[170]  J. Lehmann,et al.  Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs* , 1997, The Journal of Biological Chemistry.

[171]  D. Wallach,et al.  MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1 , 1997, Nature.

[172]  R. Woods,et al.  Mapping Histology to Metabolism: Coregistration of Stained Whole-Brain Sections to Premortem PET in Alzheimer's Disease , 1997, NeuroImage.

[173]  M. Hüll,et al.  Prostaglandin E2 Induces Interleukin‐6 Synthesis in Human Astrocytoma Cells , 1997, Journal of neurochemistry.

[174]  P. Gebicke-haerter,et al.  Expression and regulation of cyclooxygenase-2 in rat microglia. , 1997, European journal of biochemistry.

[175]  C. Colton,et al.  Activated human microglia produce the excitotoxin quinolinic acid , 1997, Neuroreport.

[176]  M. Shago,et al.  Modulation of the retinoic acid and retinoid X receptor signaling pathways in P19 embryonal carcinoma cells by calreticulin. , 1997, Experimental cell research.

[177]  S. High,et al.  Interaction of the Thiol-Dependent Reductase ERp57 with Nascent Glycoproteins , 1997, Science.

[178]  G. Kollias,et al.  Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice. , 1997, Journal of immunology.

[179]  G. Forloni Neurotoxicity of beta-amyloid and prion peptides. , 1996, Current Opinion in Neurology.

[180]  L. Otvos,et al.  Priming of monocyte respiratory burst by β-amyloid fragment (25–35) , 1996, Neuroscience Letters.

[181]  Y. Yazaki,et al.  Superoxide release and NADPH oxidase components in mature human phagocytes: correlation between functional capacity and amount of functional proteins. , 1996, Biochemical and biophysical research communications.

[182]  M. Harrison,et al.  Cyclo-oxygenase-2 Messenger RNA Induction in Focal Cerebral Ischemia , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[183]  K. Ikeda,et al.  Complement gene expression in mouse microglia and astrocytes in culture: comparisons with mouse peritoneal macrophages , 1996, Neuroscience Letters.

[184]  S. Barnum,et al.  Chronic complement C3 gene expression in the CNS of transgenic mice with astrocyte‐targeted interleukin‐6 expression , 1996, Glia.

[185]  L. Lue,et al.  Inflammation, A beta deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration. , 1996, Journal of neuropathology and experimental neurology.

[186]  Peter F. Johnson,et al.  Interleukin‐6 Induces Expression of Peripherin and Cooperates with Trk Receptor Signaling to Promote Neuronal Differentiation in PC12 Cells , 1996, Journal of neurochemistry.

[187]  J. Rogers,et al.  Relative efficacies of amyloid β peptide (Aβ) binding proteins in Aβ aggregation , 1996 .

[188]  A. Roher,et al.  Specific Domains of β-Amyloid from Alzheimer Plaque Elicit Neuron Killing in Human Microglia , 1996, The Journal of Neuroscience.

[189]  R. Wetzel,et al.  Seeding of A beta fibril formation is inhibited by all three isotypes of apolipoprotein E. , 1996, Biochemistry.

[190]  V. Perry,et al.  EVIDENCE FOR AN EARLY INFLAMMATORY RESPONSE IN THE CENTRAL NERVOUS SYSTEM OF MICE WITH SCRAPIE , 1996, Neuroscience.

[191]  Brian J Cummings,et al.  β-Amyloid converts an acute phase injury response to chronic injury responses , 1996, Neurobiology of Aging.

[192]  K. Brunden,et al.  Neuroglial-mediated immunoinflammatory responses in Alzheimer's disease: Complement activation and therapeutic approaches , 1996, Neurobiology of Aging.

[193]  J. Loike,et al.  Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils , 1996, Nature.

[194]  X. Chen,et al.  RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease , 1996, Nature.

[195]  H. Kiyama,et al.  Characteristic Localization of gpl30 (the Signal‐transducing Receptor Component Used in Common for IL‐6/IL‐11/CNTF/LIF/OSM) in the Rat Brain , 1996, The European journal of neuroscience.

[196]  J. Brandt,et al.  Regional hypometabolism in Alzheimer's disease as measured by positron emission tomography after correction for effects of partial volume averaging , 1996, Neurology.

[197]  Patrick L. McGeer,et al.  Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease , 1996, Neurology.

[198]  N. Thompson,et al.  Differential neuronal and astrocytic expression of transforming growth factor beta isoforms in rat hippocampus following transient forebrain ischemia. , 1996, Brain research. Molecular brain research.

[199]  G. Murphy,et al.  β-Amyloid Peptide Secretion by a Microglial Cell Line Is Induced by β-Amyloid-(25–35) and Lipopolysaccharide* , 1996, The Journal of Biological Chemistry.

[200]  M. Mattson,et al.  Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors , 1996, Nature Medicine.

[201]  D. Perl,et al.  Evidence of neuronal oxidative damage in Alzheimer's disease. , 1996, The American journal of pathology.

[202]  T. Taga gp130, a Shared Signal Transducing Receptor Component for Hematopoietic and Neuropoietic Cytokines , 1996, Journal of neurochemistry.

[203]  M. Baudry,et al.  Hereditary Deficiencies in Complement C5 Are Associated with Intensified Neurodegenerative Responses That Implicate New Roles for the C-System in Neuronal and Astrocytic Functions , 1996, Neurobiology of Disease.

[204]  R. Veerhuis,et al.  Amyloid β Protein Primes Cultured Rat Microglial Cells for an Enhanced Phorbol 12‐Myristate 13‐Acetate‐Induced Respiratory Burst Activity , 1996, Journal of neurochemistry.

[205]  K. Chien,et al.  Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp 130 dependent pathways. , 1996, Cytokine & growth factor reviews.

[206]  T. Dawson,et al.  Nitric oxide neurotoxicity , 1996, Journal of Chemical Neuroanatomy.

[207]  D. Sparks,et al.  Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits , 1996, Journal of Molecular Medicine.

[208]  Y. Agid,et al.  Nitric oxide synthase and neuronal vulnerability in parkinson's disease , 1996, Neuroscience.

[209]  G. Levi,et al.  Interferon‐γ and Nitric Oxide Down‐Regulate Lipopolysaccharide‐Induced Prostanoid Production in Cultured Rat Microglial Cells by Inhibiting Cyclooxygenase‐2 Expression , 1996 .

[210]  E. Matsubara,et al.  Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[211]  M. Hüll,et al.  Effects of NSAIDs on IL‐1β‐induced IL‐6 mRNA and protein synthesis in human astrocytoma cells , 1996, Neuroreport.

[212]  P. Gottschall,et al.  Increased Production of Matrix Metalloproteinases in Enriched Astrocyte and Mixed Hippocampal Cultures Treated with β‐Amyloid Peptides , 1996 .

[213]  Steven A. Johnson,et al.  Perforant Path Transection Induces Complement C9 Deposition in Hippocampus , 1996, Experimental Neurology.

[214]  L. Gold,et al.  Macrophage/microglial-mediated primary demyelination and motor disease induced by the central nervous system production of interleukin-3 in transgenic mice. , 1996, The Journal of clinical investigation.

[215]  R. Mrak,et al.  Correlation of Astrocytic S100β Expression with Dystrophic Neurites in Amyloid Plaques of Alzheimer's Disease , 1996, Journal of neuropathology and experimental neurology.

[216]  M. Bukrinsky,et al.  Cytokine‐stimulated astrocytes damage human neurons via a nitric oxide mechanism , 1996, Glia.

[217]  Brian J Cummings,et al.  Localization and Cell Association of C1q in Alzheimer's Disease Brain , 1996, Experimental Neurology.

[218]  M. Viitanen,et al.  Blunted adrenocorticotropin and increased adrenal steroid response to human corticotropin-releasing hormone in Alzheimer's disease , 1996, Biological Psychiatry.

[219]  V. Perry,et al.  Activation and Proliferation of Murine Microglia are Insensitive to Glucocorticoids in Wallerian Degeneration , 1996, The European journal of neuroscience.

[220]  G. Cole,et al.  Rodent models of Alzheimer's disease: Rat aβ infusion approaches to amyloid deposits , 1996, Neurobiology of Aging.

[221]  John Calvin Reed,et al.  Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons. , 1996, Molecular pharmacology.

[222]  Hong-Bing Shu,et al.  TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways , 1996, Cell.

[223]  G. Cole,et al.  Scavenging of Alzheimer's amyloid β‐protein by microglia in culture , 1996, Journal of neuroscience research.

[224]  Kei Yamamoto,et al.  Transcriptional Roles of Nuclear Factor B and Nuclear Factor-Interleukin-6 in the Tumor Necrosis Factor -Dependent Induction of Cyclooxygenase-2 in MC3T3-E1 Cells (*) , 1995, The Journal of Biological Chemistry.

[225]  Masanori Kato,et al.  Immunohistochemical detection of coagulation factor XIIIa in postmortem human brain tissue , 1995, Neuroscience Letters.

[226]  C. Glabe,et al.  Multivalent Binding of Complement Protein C1q to the Amyloid β-Peptide (Aβ) Promotes the Nucleation Phase of Aβ Aggregation , 1995 .

[227]  O. Bagasra,et al.  Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[228]  G. Small,et al.  Predictors of cognitive change in middle-aged and older adults with memory loss. , 1995, The American journal of psychiatry.

[229]  R. Black,et al.  A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor. , 1995, Journal of immunology.

[230]  R. Strieter,et al.  An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. , 1995, Journal of immunology.

[231]  P. Gasque,et al.  Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes. , 1995, Journal of immunology.

[232]  Armen B. Shanafelt,et al.  The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis (*) , 1995, The Journal of Biological Chemistry.

[233]  H. Wiśniewski,et al.  Apolipoproteins E3 and E4 induce, and transthyretin prevents accumulation of the Alzheimer's β-amyloid peptide in cultured vascular smooth muscle cells , 1995, Brain Research.

[234]  B. Dahlbäck,et al.  Inhibition of Alzheimer β-Peptide Fibril Formation by Serum Amyloid P Component (*) , 1995, The Journal of Biological Chemistry.

[235]  N. Peress,et al.  Differential Expression of TGF-β1, 2 and 3 Isotypes in Alzheimer's Disease: A Comparative Immunohistochemical Study with Cerebral Infarction, Aged Human and Mouse Control Brains , 1995, Journal of neuropathology and experimental neurology.

[236]  R. Jope,et al.  Inhibition of NFkB DNA binding activity by glucocorticoids in rat brain , 1995, Neuroscience Letters.

[237]  P. Mcgeer,et al.  The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases , 1995, Brain Research Reviews.

[238]  D. Munoz,et al.  Role of microglia in senile plaque formation , 1995, Neurobiology of Aging.

[239]  D. Lahiri,et al.  Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1. , 1995, Brain research. Molecular brain research.

[240]  T. Jilling,et al.  Intercellular adhesion molecule-1 gene expression by glial cells. Differential mechanisms of inhibition by IL-10 and IL-6. , 1995, Journal of immunology.

[241]  Xiao-Fan Wang,et al.  Restricted expression of type-II TGFβ receptor in murine embryonic development suggests a central role in tissue modeling and CNS patterning , 1995, Mechanisms of Development.

[242]  A. Hofman,et al.  Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease? , 1995, Neurology.

[243]  P. Kulmburg,et al.  The nomenclature of chemokines. , 1995, International archives of allergy and immunology.

[244]  D. Pollen,et al.  Altered expression of transforming growth factor-beta in Alzheimer's disease , 1995, Neurology.

[245]  B. Hyman,et al.  LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation , 1995, Cell.

[246]  M. Pericak-Vance,et al.  Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs , 1995, Neurobiology of Aging.

[247]  L. Haverkamp,et al.  Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain , 1995, Neurochemistry International.

[248]  L. Mucke,et al.  Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1. , 1995, The American journal of pathology.

[249]  J. Zweier,et al.  Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide , 1995, Nature Medicine.

[250]  R. Koeppe,et al.  A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[251]  H. Hamazaki Amyloid P Component Promotes Aggregation of Alzheimer′s β-Amyloid Peptide , 1995 .

[252]  J. Lehmann,et al.  An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ) (*) , 1995, The Journal of Biological Chemistry.

[253]  K. Unsicker,et al.  Neural functions of the transforming growth factors β , 1995, International Journal of Developmental Neuroscience.

[254]  E. Nånberg,et al.  Transfection of TRK-A into human neuroblastoma cells restores their ability to differentiate in response to nerve growth factor. , 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[255]  L. Lovat,et al.  Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[256]  P. Gasque,et al.  Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines. , 1995, Journal of immunology.

[257]  G. Ciliberto,et al.  Two distinct and independent sites on IL‐6 trigger gp 130 dimer formation and signalling. , 1995, The EMBO journal.

[258]  C. Finch,et al.  Transcriptional regulation of glial fibrillary acidic protein by corticosterone in rat astrocytes in vitro is influenced by the duration of time in culture and by astrocyte-neuron interactions. , 1995, Endocrinology.

[259]  L. Mucke,et al.  Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein , 1995, The Journal of experimental medicine.

[260]  Y. Xia,et al.  Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide. , 1995, The Journal of clinical investigation.

[261]  P. Trinder,et al.  Modulation of mRNA expression and secretion of C1q in mouse macrophages by anti-inflammatory drugs and cAMP: evidence for the partial involvement of a pathway that includes cyclooxygenase, prostaglandin E2 and adenylate cyclase. , 1995, Immunology.

[262]  B. McEwen,et al.  Stress and cognitive function , 1995, Current Opinion in Neurobiology.

[263]  D. Walker,et al.  Complement C1 inhibitor is produced by brain tissue and is cleaved in Alzheimer disease , 1995, Brain Research.

[264]  J C Mazziotta,et al.  Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease. , 1995, JAMA.

[265]  L. Lannfelt,et al.  Alpha 1-antichymotrypsin regulates Alzheimer beta-amyloid peptide fibril formation. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[266]  E. Seifritz,et al.  Hypothalamic-pituitary-adrenal system function in patients with alzheimer's disease , 1995, Neurobiology of Aging.

[267]  T. Wisniewski,et al.  Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E. , 1995, The Biochemical journal.

[268]  H. Fillit,et al.  Disorders of the extracellular matrix and the pathogenesis of senile dementia of the Alzheimer's type. , 1995, Laboratory investigation; a journal of technical methods and pathology.

[269]  D. Walker,et al.  Complement and cytokine gene expression in cultured microglia derived from postmortem human brains , 1995, Journal of neuroscience research.

[270]  Chi-Ming Lee,et al.  Complement-mediated neurotoxicity is regulated by homologous restriction , 1995, Brain Research.

[271]  B. Hyman,et al.  Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α2‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein , 1995, Annals of neurology.

[272]  P. Lansbury,et al.  Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[273]  S. Graham,et al.  Expression of cyclo-oxygenase 2 in rat brain following kainate treatment. , 1995, NeuroReport.

[274]  M. Folstein,et al.  Nonsteroidal anti-inflammatory drugs in Alzheimer's disease , 1995, Neurology.

[275]  A. Goate,et al.  The future of Alzheimer's disease research: A molecular genetic perspective , 1994, Neurobiology of Aging.

[276]  W. Thomas,et al.  Cellular forms and functions of brain microglia , 1994, Brain Research Bulletin.

[277]  T. Wisniewski,et al.  Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta. , 1994, Biochemical and biophysical research communications.

[278]  L. Mucke,et al.  Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice , 1994, Brain Research.

[279]  G. Forloni,et al.  Nonsteroidal antiinflammatory drug use in Alzheimer's disease , 1994, Biological Psychiatry.

[280]  E. Ling,et al.  The effects of subcutaneous injections of glucocorticoids on amoeboid microglia in postnatal rats. , 1994, Archives of histology and cytology.

[281]  R. Bjerkvig,et al.  Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen‐presenting cells , 1994, Journal of leukocyte biology.

[282]  D. Largaespada,et al.  Lymphotactin: a cytokine that represents a new class of chemokine. , 1994, Science.

[283]  S. O’Barr,et al.  Enhanced aggregation and β structure of amyloid β peptide after coincubation with C1Q , 1994 .

[284]  T Vogel,et al.  Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro. , 1994, The American journal of pathology.

[285]  W. Griffin,et al.  S100β protein expression in Alzheimer disease: Potential role in the pathogenesis of neuritic plaques , 1994 .

[286]  Moses Rodriguez,et al.  Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis. , 1994, Journal of immunology.

[287]  David A. Willoughby,et al.  Selective expression of clusterin (SGP-2) and complement C1qB and C4 during responses to neurotoxinsin vivo andin vitro , 1994, Neuroscience.

[288]  L. V. Van Eldik,et al.  S100 beta expression in Alzheimer's disease: relation to neuropathology in brain regions. , 1994, Biochimica et biophysica acta.

[289]  K. Seibert,et al.  In vivo glucocorticoids regulate cyclooxygenase-2 but not cyclooxygenase-1 in peritoneal macrophages. , 1994, The Journal of pharmacology and experimental therapeutics.

[290]  D. Strickland,et al.  The α2‐Macroglobulin Receptor/Low Density Lipoprotein Receptor‐Related Protein and the Receptor‐Associated Protein , 1994 .

[291]  W. Strittmatter,et al.  Transthyretin sequesters amyloid beta protein and prevents amyloid formation. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[292]  D. Walker,et al.  Hageman factor and its binding sites are present in senile plaques of Alzheimer's disease , 1994, Brain Research.

[293]  H. Arai,et al.  Demonstration of CRP immunoreactivity in brains of Alzheimer's disease: immunohistochemical study using formic acid pretreatment of tissue sections , 1994, Neuroscience Letters.

[294]  M. Mattson,et al.  Secreted Forms of β‐Amyloid Precursor Protein Protect Against Ischemic Brain Injury , 1994 .

[295]  D. Graham,et al.  Microglial interleukin-lα expression in human head injury: Correlations with neuronal and neuritic β-amyloid precursor protein expression , 1994, Neuroscience Letters.

[296]  H. Cameron,et al.  Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus , 1994, Neuroscience.

[297]  P. Peterson,et al.  Serum cytokine levels in patients with Alzheimer's disease. , 1994, Clinical and diagnostic laboratory immunology.

[298]  G. Kreutzberg,et al.  Glial β‐amyloid precursor protein: expression in the dentate gyrus after entorhinal cortex lesion , 1994, Neuroreport.

[299]  C. Cotman,et al.  beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. , 1994, Journal of immunology.

[300]  P. Mcgeer,et al.  Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease , 1994, Brain Research.

[301]  R. Myllykangas-Luosujärvi,et al.  Alzheimer's disease and rheumatoid arthritis. , 1994, British journal of rheumatology.

[302]  D. Otero,et al.  The survival of rat cerebral cortical neurons in the presence of trophic APP peptides. , 1994, Journal of neurobiology.

[303]  C. Masters,et al.  Transforming growth factor β mediates increase of mature transmembrane amyloid precursor protein in microglial cells , 1994, FEBS letters.

[304]  T. McCaffrey,et al.  Protection of transforming growth factor β activity by heparin and fucoidan , 1994 .

[305]  D. Walker,et al.  Activation of Macrophages by Alzheimer β Amyloid Peptide , 1994 .

[306]  M. Sporn,et al.  Effects of Transforming Growth Factor β1, on Scar Production in the Injured Central Nervous System of the Rat , 1994 .

[307]  W. McDonald,et al.  Inverse association of anti‐inflammatory treatments and Alzheimer's disease , 1994, Neurology.

[308]  C. Jacque,et al.  TNFα gene expression is induced in neurones after a hippocampal lesion , 1994 .

[309]  S. Barnum,et al.  Transforming growth factor-beta 1 inhibits inflammatory cytokine-induced C3 gene expression in astrocytes. , 1994, Journal of immunology.

[310]  W. Tourtellotte,et al.  Transforming growth factor beta in Alzheimer's disease , 1994, Clinical and diagnostic laboratory immunology.

[311]  Paul L. Wood,et al.  Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1β or IL-1RA but increases in the associated acute phase proteins IL-6, α2-macroglobulin and C-reactive protein , 1993, Brain Research.

[312]  T. Morgan,et al.  TGF‐β1 is an organizer of responses to neurodgeneration , 1993 .

[313]  T. Lint,et al.  Nonimmune activation of the classical complement pathway. , 1993, Behring Institute Mitteilungen.

[314]  C. Saper,et al.  Distribution and characterization of tumor necrosis factor‐α‐like immunoreactivity in the murine central nervous system , 1993 .

[315]  L. Mucke,et al.  Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[316]  E. Koo,et al.  β‐Amyloid Protein is Higher in Alzheimer's Disease Brains: Description of a Quantitative Biochemical Assay , 1993, Journal of neuropathology and experimental neurology.

[317]  B. Hyman,et al.  The Lack of Accumulation of Senile Plaques or Amyloid Burden in Alzheimer's Disease Suggests a Dynamic Balance Between Amyloid Deposition and Resolution , 1993, Journal of neuropathology and experimental neurology.

[318]  M. Mattson,et al.  Roles for calcium signaling in structural plasticity and pathology in the hippocampal system , 1993, Hippocampus.

[319]  M. Pericak-Vance,et al.  Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[320]  M. Albert,et al.  Temporal lobe regions on magnetic resonance imaging identify patients with early Alzheimer's disease. , 1993, Archives of neurology.

[321]  C. Cuénod,et al.  Amygdala atrophy in Alzheimer's disease. An in vivo magnetic resonance imaging study. , 1993, Archives of neurology.

[322]  R. Kalaria,et al.  Serine protease inhibitor antithrombin III and its messenger RNA in the pathogenesis of Alzheimer's disease. , 1993, The American journal of pathology.

[323]  G. Yancopoulos,et al.  Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. , 1993, Blood.

[324]  Carol A. Barnes,et al.  Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids , 1993, Neuron.

[325]  P. Fraser,et al.  α1‐Antichymotrypsin Binding to Alzheimer Aβ Peptides Is Sequence Specific and Induces Fibril Disaggregation In Vitro , 1993 .

[326]  F. Coria,et al.  The cellular pathology associated with Alzheimer β‐amyloid deposits in non‐demented aged individuals , 1993, Neuropathology and applied neurobiology.

[327]  T. Morgan,et al.  Transforming growth factor beta 1 and fibronectin messenger RNA in rat brain: responses to injury and cell-type localization. , 1993, Neuroscience.

[328]  D. Walker,et al.  Lactotransferrin immunocytochemistry in Alzheimer and normal human brain. , 1993, The American journal of pathology.

[329]  Steven A. Johnson,et al.  Inability to Detect β-Amyloid Protein Precursor mRNA in Alzheimer Plaque-Associated Microglia , 1993, Experimental Neurology.

[330]  T. Morgan,et al.  TGF-β1 mRNA Increases in Macrophage/Microglial Cells of the Hippocampus in Response to Deafferentation and Kainic Acid-Induced Neurodegeneration , 1993, Experimental Neurology.

[331]  D. Sibley,et al.  Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. , 1993, Molecular pharmacology.

[332]  M. Mattson,et al.  Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein , 1993, Neuron.

[333]  R. Jackson,et al.  Glial cell-specific mechanisms of TGF-β1 induction by IL-1 in cerebral cortex , 1993, Journal of Neuroimmunology.

[334]  K. Ikeda,et al.  Synthetic Alzheimer amyloid β/A4 peptides enhance production of complement C3 component by cultured microglial cells , 1993, Brain Research.

[335]  K. Hossmann,et al.  Microglial Reaction in the Rat Cerebral Cortex Induced by Cortical Spreading Depression , 1993, Brain pathology.

[336]  E. Ling,et al.  The origin and nature of ramified and amoeboid microglia: A historical review and current concepts , 1993, Glia.

[337]  D. Dickson,et al.  Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease , 1993, Glia.

[338]  V. Perry,et al.  Altered antigen expression of microglia in the aged rodent CNS , 1993, Glia.

[339]  D. Schubert,et al.  The amyloid beta-protein of Alzheimer's disease is chemotactic for mononuclear phagocytes. , 1992, Biochemical and biophysical research communications.

[340]  W. Borth α2“Macroglobulin, a multifunctional binding protein with targeting characteristics , 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[341]  R. Kyle,et al.  Proteoglycans, glycosaminoglycans, amyloid‐enhancing factor, and amyloid deposition , 1992, Journal of internal medicine.

[342]  P. Mcgeer,et al.  Thrombin accumulation in brains of patients with Alzheimer's disease , 1992, Neuroscience Letters.

[343]  S. Meri,et al.  Loss of expression of protectin (CD59) is associated with complement membrane attack complex deposition in myocardial infarction. , 1992, Laboratory investigation; a journal of technical methods and pathology.

[344]  David A. Willoughby,et al.  Complement C1qB and C4 mRNAs responses to lesioning in rat brain , 1992, Experimental Neurology.

[345]  Steven A. Johnson,et al.  Complement mRNA in the mammalian brain: Responses to Alzheimer's disease and experimental brain lesioning , 1992, Neurobiology of Aging.

[346]  P. Greengard,et al.  Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[347]  P. Mcgeer,et al.  Complement activation by beta-amyloid in Alzheimer disease. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[348]  M. Tsang,et al.  Effects of transforming growth factor-beta on murine astrocyte glutamine synthetase activity. Implications in neuronal injury. , 1992, The Journal of clinical investigation.

[349]  T. Molitor,et al.  Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. , 1992, Journal of immunology.

[350]  S. DeKosky,et al.  Neurotrophic effects of steroids on lesion-induced growth in the hippocampus II. Hormone replacement , 1992, Experimental Neurology.

[351]  K. Frei,et al.  Macrophage‐induced cytotoxicity of N‐methyl‐D‐aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines , 1992, European journal of immunology.

[352]  G. Kreutzberg,et al.  Cytotoxicity of microglia , 1992, Journal of Neuroimmunology.

[353]  H. Hatanaka,et al.  Interleukin-6 and leukemia inhibitory factor promote the survival of acetylcholinesterase-positive neurons in culture from embryonic rat spinal cord , 1992, Neuroscience Letters.

[354]  K. Nagata,et al.  Production and secretion of plasminogen in cultured rat brain microglia , 1992, FEBS letters.

[355]  M. Sporn,et al.  Enhanced expression of transforming growth factor β1 in the rat brain after a localized cerebral injury , 1992, Brain Research.

[356]  J. Silverman,et al.  A case‐control study of Alzheimer's disease in China , 1992, Neurology.

[357]  R. Kalaria,et al.  Complement inhibitor C4-binding protein in amyloid deposits containing serum amyloid P in Alzheimer's disease. , 1992, Biochemical and biophysical research communications.

[358]  S. Vandenberg,et al.  Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain. , 1992, The American journal of pathology.

[359]  David J. Anderson,et al.  CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130 , 1992, Cell.

[360]  V. Winn,et al.  cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[361]  G. Cole,et al.  Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid. , 1992, The American journal of pathology.

[362]  H. Hatanaka,et al.  Interleukin-6 as a neurotrophic factor for promoting the survival of cultured catecholaminergic neurons in a chemically defined medium from fetal and postnatal rat midbrains , 1992, Neuroscience Research.

[363]  S. Kohsaka,et al.  Microglia isolated from rat brain secrete a urokinase-type plasminogen activator , 1992, Brain Research.

[364]  S. Ishiura,et al.  Identification of Elastase as a Secretory Protease from Cultured Rat Microglia , 1992, Journal of neurochemistry.

[365]  J. Ripoche,et al.  Differential modulation by glucocorticoids of alternative complement protein secretion in cells of the monocyte/macrophage lineage , 1992, European journal of immunology.

[366]  H. Herschman,et al.  Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase. , 1992, The Journal of biological chemistry.

[367]  D. Constam,et al.  Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 3 by glioblastoma cells, astrocytes, and microglia. , 1992, Journal of immunology.

[368]  D. Walker,et al.  Reactive microglia/macrophages phagocytose amyloid precursor protein produced by neurons following neural damage , 1992, Journal of neuroscience research.

[369]  D. Marshak,et al.  Increased S100β neurotrophic activity in Alzheimer's disease temporal lobe , 1992, Neurobiology of Aging.

[370]  J. Bauer,et al.  Detection of interleukin-6 and alpha 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients. , 1992, Laboratory investigation; a journal of technical methods and pathology.

[371]  C. Jack,et al.  MR‐based hippocampal volumetry in the diagnosis of Alzheimer's disease , 1992, Neurology.

[372]  M. Sporn,et al.  Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system , 1991, Neuroscience.

[373]  V. Winn,et al.  A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein. , 1991, The Journal of biological chemistry.

[374]  R. Rice,et al.  Transglutaminases: multifunctional cross‐linking enzymes that stabilize tissues , 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[375]  S. Shimohama,et al.  Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture. , 1991, Biochemical and biophysical research communications.

[376]  K. Whaley,et al.  Modulation of complement gene expression by glucocorticoids. , 1991, The Biochemical journal.

[377]  Steven D. Carson,et al.  Tissue factor antigen in senile plaques of Alzheimer's disease. , 1991, The American journal of pathology.

[378]  B. Varnum,et al.  TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. , 1991, The Journal of biological chemistry.

[379]  U. Schreiter-Gasser,et al.  Interleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease cortices , 1991, FEBS letters.

[380]  W. Fiers,et al.  Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain? , 1991, Immunology today.

[381]  K. Yasukawa,et al.  Preparation of soluble murine IL-6 receptor and anti-murine IL-6 receptor antibodies. , 1991, Journal of immunology.

[382]  L. Kurland,et al.  Rheumatoid arthritis and susceptibility to Alzheimer's disease , 1991, The Lancet.

[383]  C. Plata-salamán Immunoregulators in the nervous system , 1991, Neuroscience & Biobehavioral Reviews.

[384]  C. Masters,et al.  In‐vitro matured human macrophages express Alzheimer's βA4‐amyloid precursor protein indicating synthesis in microglial cells , 1991, FEBS letters.

[385]  J. Orenstein,et al.  Macrophage- and astrocyte-derived transforming growth factor beta as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome , 1991, The Journal of experimental medicine.

[386]  S. Dedhar,et al.  Immunohistochemical localization of vitronectin, its receptor and beta-3 integrin in Alzheimer brain tissue , 1991, Journal of Neuroimmunology.

[387]  C. Stoner,et al.  Induction of phospholipase A2 gene expression in human hepatoma cells by mediators of the acute phase response. , 1991, The Journal of biological chemistry.

[388]  J. Wood,et al.  Tyrosine phosphorylation systems in Alzheimer's disease pathology , 1991, Neuroscience Letters.

[389]  O Nalcioglu,et al.  Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer's disease , 1991, Neurology.

[390]  T. Hirano,et al.  Molecular cloning and expression of an IL-6 signal transducer, gp130 , 1990, Cell.

[391]  T. Koepsell,et al.  A case‐control study of Alzheimer's disease , 1990, Annals of neurology.

[392]  P. Mcgeer,et al.  Brain microglia constitutively express β-2 integrins , 1990, Journal of Neuroimmunology.

[393]  Anthony F Jorm,et al.  A case‐control study of Alzheimer's disease in Australia , 1990, Neurology.

[394]  S. Styren,et al.  Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain , 1990, Experimental Neurology.

[395]  T. Saito,et al.  Purification and characterization of soluble human IL-6 receptor expressed in CHO cells. , 1990, Journal of biochemistry.

[396]  C. Colton,et al.  Chemotaxis by a CNS macrophage, the microglia , 1990, Journal of neuroscience research.

[397]  D. Mathey,et al.  Quantitative measurement of SC5b‐9 and C5b‐9(m) in infarcted areas of human myocardium , 1990, Clinical and experimental immunology.

[398]  L. Patthy Evolution of blood coagulation and fibrinolysis. , 1990, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[399]  G. Broze,et al.  Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein. , 1990, Science.

[400]  P. Mcgeer,et al.  Anti-inflammatory drugs and Alzheimer disease , 1990, The Lancet.

[401]  P. Mcgeer,et al.  Activation of the classical complement pathway in brain tissue of Alzheimer patients , 1989, Neuroscience Letters.

[402]  C. Cotman,et al.  Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[403]  P. Mcgeer,et al.  Immune System Response in Alzheimer's Disease , 1989, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[404]  K. Beyreuther,et al.  A4 Protein in Alzheimer's Disease: Primary and Secondary Cellular Events in Extracellular Amyloid Deposition , 1989, Journal of neuropathology and experimental neurology.

[405]  C. Geula,et al.  Protease nexin I immunostaining in alzheimer's disease , 1989, Annals of neurology.

[406]  J. Wegiel,et al.  Ultrastructural Studies of the Cells Forming Amyloid Fibers in Classical Plaques , 1989, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[407]  Carl W. Cotman,et al.  Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor , 1989, Nature.

[408]  H. W. Harris,et al.  Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[409]  D. Selkoe,et al.  Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease , 1989, Journal of Neuroimmunology.

[410]  W. Griffin,et al.  Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[411]  P. Eikelenboom,et al.  Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family , 1989, Neuroscience Letters.

[412]  R. Zinkernagel,et al.  On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases , 1989, European journal of immunology.

[413]  D. Scott,et al.  Rheumatold Arthritis and Senile Dementia of the Alzhelmer's Type , 1989 .

[414]  S. Styren,et al.  Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease , 1988, Neurobiology of Aging.

[415]  D. Nochlin,et al.  The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease. , 1988, The American journal of pathology.

[416]  Joseph Rogers,et al.  Immune system associated antigens expressed by cells of the human central nervous system , 1988, Neuroscience Letters.

[417]  R. Sapolsky,et al.  Chemical adrenalectomy reduces hippocampal damage induced by kainic acid , 1988, Brain Research.

[418]  W. Jagust,et al.  Quantitative NMR measurements of hippocampal atrophy in Alzheimer's disease , 1988, Magnetic resonance in medicine.

[419]  T. Hirano,et al.  Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6 , 1988, Molecular and cellular biology.

[420]  P. Mcgeer,et al.  Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains , 1988, Neurology.

[421]  J. Krebs,et al.  Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[422]  S. V. van Duinen,et al.  Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis. , 1988, Laboratory investigation; a journal of technical methods and pathology.

[423]  D. Selkoe,et al.  Immunochemical identification of the serine protease inhibitor α 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease , 1988, Cell.

[424]  W. Hickey,et al.  Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. , 1988, Science.

[425]  M. Sporn,et al.  Role of transforming growth factor-beta in the development of the mouse embryo , 1987, The Journal of cell biology.

[426]  C. Colton,et al.  Production of superoxide anions by a CNS macrophage, the microglia , 1987, FEBS letters.

[427]  M. Mallat,et al.  Primary cultures of murine astrocytes produce C3 and factor B, two components of the alternative pathway of complement activation. , 1987, Journal of immunology.

[428]  C. Cotman,et al.  Hydrocortisone administration alters glial reaction to entorhinal lesion in the rat dentate gyrus , 1987, Experimental Neurology.

[429]  W. Hickey,et al.  Graft-vs.-host disease elicits expression of class I and class II histocompatibility antigens and the presence of scattered T lymphocytes in rat central nervous system. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[430]  H. Lassmann,et al.  Cellular immune reactivity within the CNS , 1986, Trends in Neurosciences.

[431]  L. Lachman,et al.  Interleukin 1 of the central nervous system is produced by ameboid microglia , 1986, The Journal of experimental medicine.

[432]  M. Sporn,et al.  Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[433]  J. Massagué,et al.  Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. , 1986, The Journal of biological chemistry.

[434]  D. Marshak,et al.  Purification and characterization of a neurite extension factor from bovine brain. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[435]  L M Schuman,et al.  A case-control study of dementia of the Alzheimer type. , 1985, American journal of epidemiology.

[436]  C. Cotman,et al.  Lesion‐induced synaptogenesis in the dentate gyrus of aged rats: II. Demonstration of an impaired degeneration clearing response , 1982, The Journal of comparative neurology.

[437]  V. Lehto,et al.  Activation of complement by cytoskeletal intermediate filaments , 1979, Nature.

[438]  R L Kassel,et al.  An endotoxin-induced serum factor that causes necrosis of tumors. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[439]  L. Mucke,et al.  Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice. , 2000, The American journal of pathology.

[440]  R. Ransohoff,et al.  Chemokines and chemokine receptors in CNS pathology. , 1999, Journal of neurovirology.

[441]  B T Hyman,et al.  Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease. , 1999, Journal of neurovirology.

[442]  R. Horuk,et al.  Chemokine and chemokine receptor expression in the central nervous system. , 1999, Journal of neurovirology.

[443]  K. Krause,et al.  Localization of intracellular Ca2+ stores in HeLa cells during infection with Chlamydia trachomatis. , 1999, Journal of cell science.

[444]  J. Vane,et al.  Cyclooxygenases 1 and 2. , 1998, Annual review of pharmacology and toxicology.

[445]  J. Massagué TGF-beta signal transduction. , 1998, Annual review of biochemistry.

[446]  M. Beal,et al.  The neurotoxicity of amyloid beta protein in aged primates. , 1998, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

[447]  R Mielke,et al.  Positron emission tomography for diagnosis of Alzheimer's disease and vascular dementia. , 1998, Journal of neural transmission. Supplementum.

[448]  P. Aisen,et al.  Glucocorticoids in Alzheimer’s Disease , 1998 .

[449]  B. Hyman,et al.  Microglial response to amyloid plaques in APPsw transgenic mice. , 1998, The American journal of pathology.

[450]  S. Prusiner,et al.  The prion diseases. , 1998, Brain pathology.

[451]  T. Poulos,et al.  Aspartate residue 7 in amyloid β-protein is critical for classical complement pathway activation: Implications for Alzheimer's disease pathogenesis , 1997, Nature Medicine.

[452]  J. Guern,et al.  Identification of calreticulin-like protein as one of the phosphoproteins modulated in response to oligogalacturonides in tobacco cells , 1997, Planta.

[453]  H. Chang,et al.  Dehydroepiandrosterone induces the transforming growth factor-beta production by murine macrophages. , 1997, International journal of tissue reactions.

[454]  W R Markesbery,et al.  Oxidative stress hypothesis in Alzheimer's disease. , 1997, Free radical biology & medicine.

[455]  P. Gasque,et al.  Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system. , 1997, The American journal of pathology.

[456]  T. Johns,et al.  Binding of complement component Clq to myelin oligodendrocyte glycoprotein: A novel mechanism for regulating CNS inflammation , 1997 .

[457]  K. Unsicker,et al.  Expression of TGF-beta type II receptor mRNA in the CNS. , 1996, Neuroreport.

[458]  L. Amaducci,et al.  Transforming growth factor‐β1 inhibits the proliferation of rat astrocytes induced by serum and growth factors , 1995 .

[459]  K. Seibert,et al.  Regulation of prostaglandin synthesis by glucocorticoids. , 1994, Receptor.

[460]  W. Streit,et al.  Characterization of microglial reaction after middle cerebral artery occlusion in rat brain , 1993, The Journal of comparative neurology.

[461]  S. Moestrup,et al.  Immunohistochemical study of alpha 2 macroglobulin receptor in Alzheimer and control postmortem human brain. , 1993, Molecular and chemical neuropathology.

[462]  C. Cotman,et al.  Transforming growth factor-β1 is in plaques in Alzheimer and Down pathologies , 1993 .

[463]  R. Kalaria,et al.  Alpha 1-antitrypsin and alpha 1-antichymotrypsin are in the lesions of Alzheimer's disease. , 1992, Neuroreport.

[464]  S. Ju,et al.  Amyloid enhancing factor-loaded macrophages in amyloid fibril formation. , 1990, Laboratory investigation; a journal of technical methods and pathology.

[465]  P. Eikelenboom,et al.  An immunohistochemical study on cerebral vascular and senile plaque amyloid in Alzheimer’s dementia , 1984, Virchows Archiv. B, Cell pathology including molecular pathology.

[466]  Sun Js,et al.  Relationships among the complement, kinin, coagulation and fibrinolytic systems in the inflammatory reaction. , 1983 .