Testing the Protein Leverage Hypothesis in a free-living human population

The Protein Leverage Hypothesis (PLH) predicts that humans prioritize protein when regulating food intake. We tested a central prediction of PLH: protein intake will remain more constant than fat or carbohydrate in the face of dietary changes in a free-living population. Data come from a large sample of adult Filipino women participating in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) located in Philippines. Longitudinal data analysis showed that, as predicted, calories of dietary protein remained more constant over time than calories of dietary carbohydrates or fat, even if corrected for the low proportional contribution of protein to dietary energy.

[1]  P. Gerbens-Leenes,et al.  Food consumption patterns and economic growth. Increasing affluence and the use of natural resources , 2010, Appetite.

[2]  B. Popkin,et al.  Estimating body fat from anthropometry and isotopic dilution: a four-country comparison. , 2003, Obesity research.

[3]  B. Caballero,et al.  The effect of income and occupation on body mass index among women in the Cebu Longitudinal Health and Nutrition Surveys (1983-2002). , 2008, Social science & medicine.

[4]  D. Bishai,et al.  Effect of neighborhood exposures on changes in weight among women in Cebu, Philippines (1983-2002). , 2007, American journal of epidemiology.

[5]  G. Finlayson,et al.  The effect of within-meal protein content and taste on subsequent food choice and satiety. , 2011, The British journal of nutrition.

[6]  T. Sheehy,et al.  The nutrition transition in Barbados: trends in macronutrient supply from 1961 to 2003 , 2010, British Journal of Nutrition.

[7]  S. Simpson,et al.  Geometric analysis of macronutrient intake in humans: the power of protein? , 2003, Appetite.

[8]  S. Simpson,et al.  Geometric Analysis of Macronutrient Selection in the Rat , 1997, Appetite.

[9]  D. Mela.  Eating for pleasure or just wanting to eat? Reconsidering sensory hedonic responses as a driver of obesity , 2006, Appetite.

[10]  Frank B. Hu,et al.  The Effects of High Protein Diets on Thermogenesis, Satiety and Weight Loss: A Critical Review , 2004, Journal of the American College of Nutrition.

[11]  L. Adair,et al.  International Journal of Behavioral Nutrition and Physical Activity Offspring Consume a More Obesogenic Diet than Mothers in Response to Changing Socioeconomic Status and Urbanization in Cebu, Philippines , 2022 .

[12]  L. Adair,et al.  20-year trends in Filipino women's weight reflect substantial secular and age effects. , 2011, The Journal of nutrition.

[13]  S. Simpson,et al.  Testing Protein Leverage in Lean Humans: A Randomised Controlled Experimental Study , 2011, PloS one.

[14]  B. Popkin,et al.  Ethnic differences in the association between body mass index and hypertension. , 2002, American journal of epidemiology.

[15]  Linda Richter,et al.  Maternal and child undernutrition: consequences for adult health and human capital , 2008, The Lancet.

[16]  B. Popkin,et al.  Cohort profile: the Cebu longitudinal health and nutrition survey. , 2011, International journal of epidemiology.

[17]  Monica Mars,et al.  Protein status elicits compensatory changes in food intake and food preferences123 , 2011, The American journal of clinical nutrition.

[18]  B. Popkin,et al.  Global nutrition dynamics: the world is shifting rapidly toward a diet linked with noncommunicable diseases. , 2006, The American journal of clinical nutrition.

[19]  S. Jebb,et al.  Dietary determinants of obesity , 2007, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[20]  S. Simpson,et al.  Obesity: the protein leverage hypothesis , 2005, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[21]  Stijn Soenen and Margriet S. Westerterp Plantenga.  Proteins and satiety: implications for weight management , 2008 .

[22]  S. Simpson,et al.  Protein‐leverage in Mice: The Geometry of Macronutrient Balancing and Consequences for Fat Deposition , 2008, Obesity.

[23]  S. Simpson,et al.  The price of protein: combining evolutionary and economic analysis to understand excessive energy consumption , 2010, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[24]  L. Adair,et al.  Quantifying the urban environment: a scale measure of urbanicity outperforms the urban-rural dichotomy. , 2007, Social science & medicine.

[25]  J. Purnell,et al.  A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations. , 2005, The American journal of clinical nutrition.