Relationship between mammographic density and the risk of breast cancer in japanese women: a case-control study

BackgroundThe relationship between mammographic density and the risk of breast cancer was examined in Japanese women. The study was a matched case-control study comparing the mammographic densities of both breast cancer cases and healthy controls.Materials and MethodsWe selected 237 women who were diagnosed with a histologically verified breast cancer, and who underwent surgery at Gihoku General Hospital in Gifu, from January, 1998 to December, 1999. During the time of this study, 3,650 people participated in breast cancer screening with mammography and ultrasound together. We selected 742 women as a control group from the screening participants and matched them by age and the number of deliveries with the cancer patients. The same mammography machine was used for both cases and controls. For evaluation, we used a visual method (Wolfe’s classification) and a computer assisted method to classify the mammograms based on mammographic density.Results1 According to Wolfe’s classification, the DY group had a significantly increased breast cancer risk compared with the N1 group (Relative risk (RR) = 2.20, 95%confidence interval (95%CI) (1.02-4.77). 2 The group showing a high mammographic density had a significantly increased risk of breast cancer compared with the group with low mammographic density (RR = 2.83, 95%CI = 1.33-5.98) as classified by the computer assisted method.ConclusionIt is suggested that women with high mammographic densities, classified visually or by computer, have an elevated risk of breast cancer compared with those with low mammographic densities.

[1]  A. Morrison,et al.  Height and weight, mammographic features of breast tissue, and breast cancer risk. , 1984, American journal of epidemiology.

[2]  N F Boyd,et al.  Breast cancer risk and measured mammographic density , 1998, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[3]  N. Boyd,et al.  The risk of breast cancer associated with mammographic parenchymal patterns: a meta-analysis of the published literature to examine the effect of method of classification. , 1992, Cancer detection and prevention.

[4]  E. Fishell,et al.  Radio-free America: what to do with the waste. , 1994, Environmental health perspectives.

[5]  S. Brünner,et al.  The risk of developing breast cancer in relation to mammography findings. , 1984, European journal of radiology.

[6]  G. Maskarinec,et al.  A case-control study of mammographic densities in Hawaii , 2000, Breast Cancer Research and Treatment.

[7]  M Lipkin,et al.  Genetic and nutritional modulation of colon cancer development. , 1996, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[8]  R N Hoover,et al.  Mammographic densities and risk of breast cancer , 1991, Cancer.

[9]  A. Miller,et al.  Quantitative classification of mammographic densities and breast cancer risk: results from the Canadian National Breast Screening Study. , 1995, Journal of the National Cancer Institute.

[10]  R. Warren,et al.  Mammographic screening and mammographic patterns , 2000, Breast Cancer Research.

[11]  M. Hakama,et al.  Risk of breast cancer and changes in mammographic parenchymal patterns over time. , 1998, Acta oncologica.

[12]  M. Sasa,et al.  Breast cancer screening by mammography in women aged under 50 years in Japan. , 2000, Anticancer research.

[13]  J. Wolfe,et al.  Mammographic features and breast cancer risk: effects with time, age, and menopause status. , 1995, Journal of the National Cancer Institute.

[14]  J. Wolfe Breast patterns as an index of risk for developing breast cancer. , 1976, AJR. American journal of roentgenology.

[15]  S. Duffy,et al.  Mammographic parenchymal patterns and mode of detection: implications for the breast screening programme , 1998, Journal of medical screening.

[16]  E. Thurfjell,et al.  Breast size and mammographic pattern in relation to breast cancer risk. , 1996, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.