Biologically active leptin-related synthetic peptides activate STAT3 via phosphorylation of ERK1/2 and PI-3K

[1]  D. Levy,et al.  The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation , 2013, PloS one.

[2]  F. B. Davis,et al.  Nuclear monomeric integrin αv in cancer cells is a coactivator regulated by thyroid hormone , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[3]  M. Leinung,et al.  [D-Leu-4]-OB3, an orally bioavailable leptin-related synthetic peptide insulin sensitizer: A study comparing the efficacies of [D-Leu-4]-OB3 and metformin on energy balance and glycemic regulation in insulin-deficient male Swiss Webster mice , 2013, Peptides.

[4]  M. Leinung,et al.  [d-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, augments the effects of orally delivered exenatide and pramlintide acetate on energy balance and glycemic control in insulin-resistant male C57BLK/6-m db/db mice , 2012, Regulatory Peptides.

[5]  F. B. Davis,et al.  Crosstalk between Integrin αvβ3 and Estrogen Receptor-α Is Involved in Thyroid Hormone-Induced Proliferation in Human Lung Carcinoma Cells , 2011, PloS one.

[6]  P. Davis,et al.  Inducible COX-2-dependent apoptosis in human ovarian cancer cells. , 2011, Carcinogenesis.

[7]  C. Elias,et al.  The PI3K signaling pathway mediates the biological effects of leptin. , 2010, Arquivos brasileiros de endocrinologia e metabologia.

[8]  M. Leinung,et al.  Intranasal delivery of mouse [D‐Leu‐4]‐OB3, a synthetic peptide amide with leptin‐like activity, improves energy balance, glycaemic control, insulin sensitivity and bone formation in leptin‐resistant C57BLK/6‐m db/db mice , 2010, Diabetes, obesity & metabolism.

[9]  T. Ide,et al.  Direct evidence for leptin-induced lipid oxidation independent of long-form leptin receptor. , 2010, Biochimica et biophysica acta.

[10]  M. Leinung,et al.  Oral delivery of mouse [d‐Leu‐4]‐OB3, a synthetic peptide amide with leptin‐like activity, in male C57BL/6J wild‐type and ob/ob mice: effects on energy balance, glycaemic control and serum osteocalcin levels , 2010, Diabetes, obesity and metabolism.

[11]  M. Leinung,et al.  Oral delivery of mouse [D-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, in male Swiss Webster mice: A study comparing the pharmacokinetics of oral delivery to intraperitoneal, subcutaneous, intramuscular, and intranasal administration , 2010, Regulatory Peptides.

[12]  M. Leinung,et al.  Intranasal administration of mouse [D-Leu-4]OB3, a synthetic peptide amide with leptin-like activity, enhances total uptake and bioavailability in Swiss Webster mice when compared to intraperitoneal, subcutaneous, and intramuscular delivery systems , 2009, Regulatory Peptides.

[13]  A. Miranda,et al.  Evaluation of new leptin fragments on food intake and body weight of normal rats , 2009, Regulatory Peptides.

[14]  M. Koch,et al.  Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways , 1997, Diabetologia.

[15]  J. Pesquero,et al.  In vitro evaluation of leptin fragments activity on the ob receptor , 2008, Journal of peptide science : an official publication of the European Peptide Society.

[16]  Hung-Yun Lin,et al.  Acting via a cell surface receptor, thyroid hormone is a growth factor for glioma cells. , 2006, Cancer research.

[17]  M. T. Miranda,et al.  Leptin fragments induce Fos immunoreactivity in rat hypothalamus , 2005, Regulatory Peptides.

[18]  G. Nussdorfer,et al.  Effects of leptin and leptin fragments on steroid secretion of freshly dispersed rat adrenocortical cells , 2003, The Journal of Steroid Biochemistry and Molecular Biology.

[19]  Alexander S. Banks,et al.  Regulation of Jak Kinases by Intracellular Leptin Receptor Sequences* , 2002, The Journal of Biological Chemistry.

[20]  Y. Nomura,et al.  Leptin regulates interleukin-1β expression in the brain via the STAT3-independent mechanisms , 2002, Brain Research.

[21]  F. Milagro,et al.  Immunomanipulation of appetite and body temperature through the functional mimicry of leptin. , 2002, Obesity research.

[22]  M. Schwartz,et al.  Intracellular signalling: Key enzyme in leptin-induced anorexia , 2001, Nature.

[23]  M. Leinung,et al.  [d-LEU-4]-OB3, a synthetic leptin agonist, improves hyperglycemic control in C57BL/6J ob/ob mice , 2001, Regulatory Peptides.

[24]  G. Wolf,et al.  Leptin stimulates type I collagen production in db/db mesangial cells: Glucose uptake and TGF-β type II receptor expression , 2001 .

[25]  J. Flier,et al.  SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985 * , 2000, The Journal of Biological Chemistry.

[26]  M. Leinung,et al.  Design of a synthetic leptin agonist: effects on energy balance, glucose homeostasis, and thermoregulation. , 2000, Endocrinology.

[27]  Alexander S. Banks,et al.  Activation of Downstream Signals by the Long Form of the Leptin Receptor* , 2000, The Journal of Biological Chemistry.

[28]  E. Krebs,et al.  Leptin Induces Insulin-like Signaling That Antagonizes cAMP Elevation by Glucagon in Hepatocytes* , 2000, The Journal of Biological Chemistry.

[29]  M. Leinung,et al.  Epitope mapping of secreted mouse leptin utilizing peripherally administered synthetic peptides , 1999, Regulatory Peptides.

[30]  L. Tartaglia,et al.  Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. , 1999, Diabetes.

[31]  M. Tena-Sempere,et al.  Leptin116–130 Stimulates Prolactin and Luteinizing Hormone Secretion in Fasted Adult Male Rats , 1999, Neuroendocrinology.

[32]  G. Nussdorfer,et al.  LEPTIN(116-130) ENHANCES THE PROLIFERATIVE ACTIVITY OF IMMATURE RAT ADRENAL CORTEX , 1999 .

[33]  J. Flier,et al.  Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor* , 1997, The Journal of Biological Chemistry.

[34]  K. Chihara,et al.  Leptin Induces Mitogen-activated Protein Kinase- dependent Proliferation of C3H10T1/2 Cells* , 1997, The Journal of Biological Chemistry.

[35]  M. Leinung,et al.  In VivoEffects of Leptin-Related Synthetic Peptides on Body Weight and Food Intake in Female ob/obMice: Localization of Leptin Activity to Domains Between Amino Acid Residues 106-140. , 1997, Endocrinology.

[36]  L. Tartaglia,et al.  The Leptin Receptor* , 1997, The Journal of Biological Chemistry.

[37]  T. Murakami,et al.  A short form of leptin receptor performs signal transduction. , 1997, Biochemical and biophysical research communications.

[38]  J. Darnell,et al.  Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice , 1996, Nature Genetics.

[39]  L. Tartaglia,et al.  The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[40]  J. Darnell,et al.  Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation , 1995, Cell.