Stability of regional cerebral glucose metabolism in the normal brain measured by positron emission tomography.

Cerebral glucose utilization (LCMRGI) was measured using the [18F]fluorodeoxyglucose method with PET in two groups of ten healthy young volunteers, each scanned in a resting state under different methodological conditions. In addition, five subjects had a second scan within 48 hr. Mean hemispheric values averaged 45.8 +/- 3.3 mumol/100 g/min in the right cerebral hemisphere and 47.0 +/- 3.7 mumol/100 g/min in the left hemisphere. A four-way analysis of variance (group, sex, region, hemisphere) was carried out on the results using three different methods of data manipulation: (a) the raw values of glucose utilization, (b) LCMRGI values "normalized" by the mean hemispheric gray matter LCMRGI value, and (c) log transformed LCMRGI values. For all analysis techniques, significantly higher LCMRGI values were consistently seen in the left mid and posterior temporal area and caudate nucleus relative to the right, and in the right occipital region relative to the left. The coefficient of variation of intrasubject regional differences (9.9%) was significantly smaller than the coefficient of variation for regions between subjects (16.5%). No differences were noted between the sexes and no effect of repeat procedures was seen in subjects having multiple scans. In addition, inter-regional LCMRGI correlations were examined both in values from the 20 normal subjects, as well as in a set of hypothetical "abnormal" values. Results were compared with those reported from other PET centers; despite certain methodological differences, the intersubject and inter-regional variation of LCMRGI is fairly constant.

[1]  J. Mazziotta,et al.  Tomographic mapping of human cerebral metabolism , 1981, Neurology.

[2]  K Wienhard,et al.  Journal of Cerebral Blood Flow and Metabolism Comparative Regional Analysis of 2-fluorodeoxyglucose and Methylglucose Uptake in Brain of Four Stroke Patients. with Special Reference to the Regional Estimation of the Lumped Constant , 2022 .

[3]  J. Baron,et al.  Local Interrelationships of Cerebral Oxygen Consumption and Glucose Utilization in Normal Subjects and in Ischemic Stroke Patients: A Positron Tomography Study , 1984, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[4]  D. Kuhl Imaging local brain function with emission computed tomography. , 1984, Radiology.

[5]  R A Brooks,et al.  Alternative formula for glucose utilization using labeled deoxyglucose. , 1982, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[6]  Evans Ac,et al.  A phantom to assess quantitative recovery of positron tomographs. , 1983 .

[7]  R. Carson,et al.  Alternative Statistical Models for the Examination of Clinical Positron Emission Tomography/Fluorodeoxyglucose Data , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[8]  M E Phelps,et al.  Cerebral Metabolic Relationships for Selected Brain Regions in Healthy Adults , 1984, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[9]  W. Barker,et al.  Age and sex differences in cerebral glucose consumption measured by pet using (18-F) fluorodeoxyglucose (FDG) , 1985 .

[10]  J C Mazziotta,et al.  Tomographic mapping of human cerebral metabolism: Sensory deprivation , 1982, Annals of neurology.

[11]  B. J. Winer,et al.  Statistical Principles in Experimental Design, 2nd Edition. , 1973 .

[12]  K. Herholz,et al.  Regional Kinetic Constants and Cerebral Metabolic Rate for Glucose in Normal Human Volunteers Determined by Dynamic Positron Emission Tomography of [18F]-2-Fluoro-2-Deoxy-D-Glucose , 1984, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[13]  A. M. Sendyk,et al.  Performance Figures and Images from the Therascan 3128 Positron Emission Tomograph , 1984, IEEE Transactions on Nuclear Science.

[14]  Helena C. Kraemer,et al.  Improved Approximation to the Non-Null Distribution of the Correlation Coefficient , 1973 .

[15]  Michael E. Phelps,et al.  Effects of Human Aging on Patterns of Local Cerebral Glucose Utilization Determined by the [18F] Fluorodeoxyglucose Method , 1982, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[16]  L. Sokoloff,et al.  Human brain glucose utilization and cognitive function in relation to age , 1984, Annals of neurology.

[17]  G. A. Ferguson,et al.  Statistical analysis in psychology and education , 1960 .

[18]  C. Bohm,et al.  Correction for Scattered Radiation in a Ring Detector Positron Camera by Integral Transformation of the Projections , 1983, Journal of computer assisted tomography.

[19]  M E Phelps,et al.  Performance evaluation of a positron tomograph designed for brain imaging. , 1983, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[20]  A. Alavi,et al.  Measurement of Local Cerebral Glucose Metabolism: Application to the Study of Stroke , 1983 .

[21]  M. Ter-pogossian,et al.  PETT VI: A Positron Emission Tomograph Utilizing Cesium Fluoride Scintillation Detectors , 1982, Journal of computer assisted tomography.

[22]  B. J. Winer Statistical Principles in Experimental Design , 1992 .

[23]  E. Meyer,et al.  POSITOME II: A HIGH EFFICIENCY PET DEVICE FOR DYNAMIC STUDIES , 1978 .

[24]  C. Bohm,et al.  Determination of Object Contour from Projections for Attenuation Correction in Cranial Positron Emission Tomography , 1982, Journal of computer assisted tomography.

[25]  M. Reivich,et al.  THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1 , 1977, Journal of neurochemistry.