Biokinetics and dosimetry of 18F‐PSMA‐1007 in patients with prostate cancer

Positron emission tomography‐computed tomography (PET‐CT) using prostate‐specific membrane antigen (PSMA) ligands is a method for imaging prostate cancer. A recent tracer, 18F‐PSMA‐1007, offers advantages concerning production and biokinetics compared to the standard tracer (68Ga‐PSMA‐11). Until now, radiation dosimetry data for this ligand was limited to the material of three healthy volunteers. The purpose of this study is to study the biokinetics and dosimetry of 18F‐PSMA‐1007.

[1]  E. Trägårdh,et al.  Tumor Detection of 18F-PSMA-1007 in the Prostate Gland in Patients with Prostate Cancer Using Prostatectomy Specimens as Reference Method , 2021, The Journal of Nuclear Medicine.

[2]  T. Watabe,et al.  High detection rate in [18F]PSMA-1007 PET: interim results focusing on biochemical recurrence in prostate cancer patients , 2021, Annals of Nuclear Medicine.

[3]  A. Piccardo,et al.  Diagnostic Role of 18F-PSMA-1007 PET/CT in Prostate Cancer Staging: A Systematic Review , 2021, Diagnostics.

[4]  A. Jemal,et al.  Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries , 2021, CA: a cancer journal for clinicians.

[5]  T. Holland-Letz,et al.  Diagnostic Accuracy of 18F-PSMA-1007 PET/CT Imaging for Lymph Node Staging of Prostate Carcinoma in Primary and Biochemical Recurrence , 2020, The Journal of Nuclear Medicine.

[6]  Lars Edenbrandt,et al.  RECOMIA—a cloud-based platform for artificial intelligence research in nuclear medicine and radiology , 2020, EJNMMI Physics.

[7]  N. Lawrentschuk,et al.  Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multicentre study , 2020, The Lancet.

[8]  P. Carroll,et al.  Assessment of 68Ga-PSMA-11 PET Accuracy in Localizing Recurrent Prostate Cancer: A Prospective Single-Arm Clinical Trial. , 2019, JAMA oncology.

[9]  Sören Mattsson,et al.  IDAC-Dose 2.1, an internal dosimetry program for diagnostic nuclear medicine based on the ICRP adult reference voxel phantoms , 2017, EJNMMI Research.

[10]  B. Hadaschik,et al.  F-18 labelled PSMA-1007: biodistribution, radiation dosimetry and histopathological validation of tumor lesions in prostate cancer patients , 2016, European Journal of Nuclear Medicine and Molecular Imaging.

[11]  N Petoussi-Henss,et al.  ICRP Publication 133: The ICRP computational framework for internal dose assessment for reference adults: specific absorbed fractions , 2016, Annals of the ICRP.

[12]  M. Schwaiger,et al.  Diagnostic Efficacy of (68)Gallium-PSMA Positron Emission Tomography Compared to Conventional Imaging for Lymph Node Staging of 130 Consecutive Patients with Intermediate to High Risk Prostate Cancer. , 2016, The Journal of urology.

[13]  Icrp ICRP Publication 128: Radiation Dose to Patients from Radiopharmaceuticals: a Compendium of Current Information Related to Frequently Used Substances , 2015 .

[14]  T. Realini,et al.  Calculated CT Volumes of Lacrimal Glands in Normal Caucasian Orbits , 2013, Ophthalmic plastic and reconstructive surgery.

[15]  P. Deluca,et al.  Realistic reference phantoms: An ICRP/ICRU joint effort , 2009, Annals of the ICRP.

[16]  S. Shen,et al.  Improved prediction of myelotoxicity using a patient-specific imaging dose estimate for non-marrow-targeting (90)Y-antibody therapy. , 2002, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[17]  J. Valentin Basic anatomical and physiological data for use in radiological protection: reference values , 2002, Annals of the ICRP.

[18]  K. Maclennan,et al.  Prostate-specific membrane antigen: evidence for the existence of a second related human gene. , 1995, British Journal of Cancer.

[19]  G Sgouros,et al.  Bone marrow dosimetry for radioimmunotherapy: theoretical considerations. , 1993, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[20]  T. Holland-Letz,et al.  Urological Oncology: Prostate Cancer Re: Diagnostic Accuracy of F-PSMA-1007-PET/CT Imaging for Lymph Node Staging of Prostate Carcinoma in Primary and Biochemical Recurrence , 2020 .

[21]  J. Valentin,et al.  The 2007 Recommendations of the International Commission on Radiological Protection. ICRP publication 103. , 2007, Annals of the ICRP.