The BRCA2 gene product functionally interacts with p53 and RAD51.
暂无分享,去创建一个
T. Ouchi | S. Aaronson | S A Aaronson | L Y Marmorstein | T Ouchi | Stuart A. Aaronson | L. Marmorstein
[1] C. Sherr. The ins and outs of RB: coupling gene expression to the cell cycle clock. , 1994, Trends in cell biology.
[2] T. Mak,et al. Partial rescue of Brca15–6 early embryonic lethality by p53 or p21 null mutation , 1997, Nature Genetics.
[3] P. Bartel,et al. RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2 * , 1997, The Journal of Biological Chemistry.
[4] H. Gardner,et al. Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues. , 1997, Developmental biology.
[5] L. Chodosh,et al. Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[6] Francis S. Collins,et al. Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer , 1994, Nature Genetics.
[7] T. Lindahl. Facts and Artifacts of Ancient DNA , 1997, Cell.
[8] J. Rommens,et al. Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families , 1994, Nature Genetics.
[9] A. Ashworth,et al. Nuclear location and cell cycle regulation of the BRCA2 protein. , 1997, Cancer research.
[10] U. Knippschild,et al. p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. , 1996, The EMBO journal.
[11] A. Ashworth,et al. The BRC repeats are conserved in mammalian BRCA2 proteins. , 1997, Human molecular genetics.
[12] T. Mak,et al. Brca2 is required for embryonic cellular proliferation in the mouse. , 1997, Genes & development.
[13] F. Couch,et al. Mutations of the BRCA2 gene in ovarian carcinomas. , 1996, Cancer research.
[14] P. Hasty,et al. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53 , 1996, Molecular and cellular biology.
[15] P. Bork,et al. Internal repeats in the BRCA2 protein sequence , 1996, Nature Genetics.
[16] P. Leder,et al. Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. , 1995, Genes & development.
[17] A. Berchuck,et al. Cell cycle control of BRCA2. , 1996, Cancer research.
[18] C. Larsson,et al. Mutation analysis of the BRCA2 gene in 49 site–specific breast cancer families , 1996, Nature Genetics.
[19] B. Ponder,et al. Involvement of Brca2 in DNA repair. , 1998, Molecular cell.
[20] F. Alt,et al. RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[21] M. Skolnick,et al. Low incidence of BRCA2 mutations in breast carcinoma and other cancers , 1996, Nature Genetics.
[22] Sheila Seal,et al. BRCA2 mutations in primary breast and ovarian cancers , 1996, Nature Genetics.
[23] A. Ashworth,et al. Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation , 1997, Nature Genetics.
[24] I. Verma,et al. Transcriptional activation by BRCA1 , 1996, Nature.
[25] Steven E. Bayer,et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. , 1994, Science.
[26] S. Seal,et al. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. , 1994, Science.
[27] Luke Hughes-Davies,et al. Transcriptional activation functions in BRCA2 , 1997, Nature.
[28] N Risch,et al. Genetic analysis of breast cancer in the cancer and steroid hormone study. , 1991, American journal of human genetics.
[29] L. Bennett,et al. Characterization of the rat and mouse homologues of the BRCA2 breast cancer susceptibility gene. , 1997, Cancer research.
[30] J. Rommens,et al. The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds , 1996, Nature Genetics.
[31] J Chang-Claude,et al. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. , 1998, American journal of human genetics.
[32] G. Eichele,et al. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 , 1997, Nature.
[33] B. Koller,et al. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities , 1996, Nature Genetics.
[34] K. Nakao,et al. Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[35] Junzhe Xu,et al. The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues , 1995, Nature Genetics.
[36] Yusuke Nakamura,et al. Mutation analysis in the BRCA2 gene in primary breast cancers , 1996, Nature Genetics.
[37] Danny Reinberg,et al. A human RNA polymerase II complex associated with SRB and DNA-repair proteins , 1996, Nature.
[38] J. Rossant,et al. The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse , 1996, Cell.
[39] C. Harris,et al. Interaction of p53 with the human Rad51 protein. , 1997, Nucleic acids research.
[40] H. Hanafusa,et al. Evidence for a transcriptional activation function of BRCA1 C-terminal region. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[41] Patrick Dowd,et al. Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families , 1994, Nature Genetics.
[42] Y. Chen,et al. The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[43] D. Bentley,et al. Identification of the breast cancer susceptibility gene BRCA2 , 1995, Nature.
[44] C. Moskaluk,et al. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. , 1996, Cancer research.
[45] T. Ludwig,et al. Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. , 1997, Genes & development.
[46] Hongbing Zhang,et al. BRCA1, BRCA2, and DNA Damage Response: Collision or Collusion? , 1998, Cell.
[47] M. Skolnick,et al. BRCA1 mutations in primary breast and ovarian carcinomas. , 1994, Science.
[48] A. Levine. p53, the Cellular Gatekeeper for Growth and Division , 1997, Cell.
[49] H. Nguyen,et al. Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells. , 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.