Automated segmentation of lumbar vertebrae in digital videofluoroscopic images

Low back pain is a significant problem in the industrialized world. Diagnosis of the underlying causes can be extremely difficult. Since mechanical factors often play an important role, it can be helpful to study the motion of the spine. Digital videofluoroscopy has been developed for this study and it can provide image sequences with many frames, but which often suffer due to noise, exacerbated by the very low radiation dosage. Thus, determining vertebra position within the image sequence presents a considerable challenge. There have been many studies on vertebral image extraction, but problems of repeatability, occlusion and out-of-plane motion persist. In this paper, we show how the Hough transform (HT) can be used to solve these problems. Here, Fourier descriptors were used to describe the vertebral body shape. This description was incorporated within our HT algorithm from which we can obtain affine transform parameters, i.e., scale, rotation and center position. The method has been applied to images of a calibration model and to images from two sequences of moving human lumbar spines. The results show promise and potential for object extraction from poor quality images and that models of spinal movement can indeed be derived for clinical application.

[1]  M. Panjabi,et al.  An Analysis of Errors in Kinematic Parameters Associated with in Vivo Functional Radiographs , 1992, Spine.

[2]  Isaac N. Bankman,et al.  Handbook of medical imaging , 2000 .

[3]  Milan Sonka,et al.  Automated initialization and automated design of border detection criteria in edge-based image segmentation , 2000, 4th IEEE Southwest Symposium on Image Analysis and Interpretation.

[4]  N. Bogduk Clinical Anatomy of the Lumbar Spine and Sacrum , 1997 .

[5]  Charles R. Giardina,et al.  Elliptic Fourier features of a closed contour , 1982, Comput. Graph. Image Process..

[6]  Hiroshi Aradate,et al.  Development and evaluation of a real-time three-dimensional CT (4D-CT) scanner , 2002, SPIE Medical Imaging.

[7]  Jack Sklansky,et al.  Finding circles by an array of accumulators , 1975, Commun. ACM.

[8]  J. Porterfield,et al.  Mechanical Low Back Pain: Perspectives in Functional Anatomy , 1991 .

[9]  Mark S. Nixon,et al.  Parameterizing Arbitrary Shapes via Fourier Descriptors for Evidence-Gathering Extraction , 1998, Comput. Vis. Image Underst..

[10]  Richard O. Duda,et al.  Use of the Hough transformation to detect lines and curves in pictures , 1972, CACM.

[11]  Leonard H van den Berg,et al.  A way out of the maze , 2005, Neurology.

[12]  Keith Case,et al.  Computer aided modelling of the human spine , 1999 .

[13]  Mw Van Tulder Spinal radiographic findings and nonspecific low back pain , 1997 .

[14]  J. P. Jones,et al.  Foundations of Medical Imaging , 1993 .

[15]  O DudaRichard,et al.  Use of the Hough transformation to detect lines and curves in pictures , 1972 .

[16]  M H Pope,et al.  Biomechanical Definitions of Spinal Instability , 1985, Spine.

[17]  M. Nixon,et al.  On the intimate relationship between the principle of duality and the Hough transform , 2000, Proceedings of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.

[18]  V. F. Leavers,et al.  Which Hough transform , 1993 .

[19]  Robert Allen,et al.  Calculation of planar spine kinematic parameters using videofluoroscopic images and parallel computation , 1993, Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ.

[20]  Josef Kittler,et al.  A survey of the hough transform , 1988, Comput. Vis. Graph. Image Process..

[21]  Christopher J. Taylor,et al.  Automatic measurement of vertebral shape using active shape models , 1997, Image Vis. Comput..

[22]  J M Muggleton,et al.  Automatic location of vertebrae in digitized videofluoroscopic images of the lumbar spine. , 1997, Medical engineering & physics.

[23]  R. Allen,et al.  Measurement of spine motion for diagnosis of mechanical problems , 2000 .

[24]  D B Allan,et al.  An historical perspective on low back pain and disability. , 1989, Acta orthopaedica Scandinavica. Supplementum.

[25]  Anthony P. Reeves,et al.  Three-Dimensional Generalized Hough Transform For Object Identification , 1990, Other Conferences.

[26]  A Breen,et al.  A digital videofluoroscopic technique for spine kinematics. , 1989, Journal of medical engineering & technology.

[27]  Manohar M. Panjabi,et al.  Clinical Biomechanics of the Spine , 1978 .

[28]  E KALLIO,et al.  Injuries of the thoraco-lumbar spine with paraplegia. , 1963, Acta orthopaedica Scandinavica. Supplementum.

[29]  David J. Farber,et al.  A Parallel Mechanism for Detecting Curves in Pictures , 1975, IEEE Transactions on Computers.

[30]  Philippe Cinquin,et al.  Kinematic study of lumbar spine using functional radiographies and 3D/2D registration , 1997, CVRMed.

[31]  J M Muggleton,et al.  Insights into the measurement of vertebral translation in the sagittal plane. , 1998, Medical engineering & physics.

[32]  Mark S. Nixon,et al.  Dynamic feature extraction via the velocity Hough transform , 1997, Pattern Recognit. Lett..

[33]  Dana H. Ballard,et al.  Generalizing the Hough transform to detect arbitrary shapes , 1981, Pattern Recognit..

[34]  Osamu Nakai,et al.  Dynamic Motion Study of the Whole Lumbar Spine by Videofluoroscopy , 1998, Spine.

[35]  Jack Sklansky,et al.  On the Hough Technique for Curve Detection , 1978, IEEE Transactions on Computers.

[36]  E P Steinberg,et al.  Trends in diagnostic imaging for low back pain: has MR imaging been a substitute or add-on? , 1997, Radiology.

[37]  M. H. Pope,et al.  Lumbar segmental instability , 1999 .

[38]  M J Pearcy,et al.  Instantaneous Axes of Rotation of the Lumbar Intervertebral Joints , 1988, Spine.

[39]  Lex M. Bouter,et al.  Spinal Radiographic Findings and Nonspecific Low Back Pain: A Systematic Review of Observational Studies , 1997, Spine.

[40]  Milan Sonka,et al.  Object localization and border detection criteria design in edge-based image segmentation: automated learning from examples , 2000, IEEE Transactions on Medical Imaging.

[41]  三村 雅也,et al.  Rotational instability of the lumbar spine : a three-dimensional motion study using bi-plane X-ray analysis system , 1990 .