From fragments to leads: novel bacterial NAD+-dependent DNA ligase inhibitors

[1]  A. Hopkins,et al.  The role of ligand efficiency metrics in drug discovery , 2014, Nature Reviews Drug Discovery.

[2]  P. Boriack-Sjodin,et al.  Identification through structure-based methods of a bacterial NAD(+)-dependent DNA ligase inhibitor that avoids known resistance mutations. , 2014, Bioorganic & medicinal chemistry letters.

[3]  Ce-Feng Liu,et al.  Antimicrobial Activity of Adenine-Based Inhibitors of NAD(+)-Dependent DNA Ligase. , 2012, ACS medicinal chemistry letters.

[4]  F. Maltais,et al.  Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: aminoalkoxypyrimidine carboxamides. , 2012, Bioorganic & medicinal chemistry letters.

[5]  H. Giamarellou,et al.  Multidrug-Resistant Gram-Negative Infections , 2009, Drugs.

[6]  M. Gowravaram,et al.  Discovery of bacterial NAD⁺-dependent DNA ligase inhibitors: improvements in clearance of adenosine series. , 2012, Bioorganic & medicinal chemistry letters.

[7]  M. Gowravaram,et al.  Discovery of bacterial NAD+-dependent DNA ligase inhibitors: optimization of antibacterial activity. , 2011, Bioorganic & medicinal chemistry letters.

[8]  S. Shuman.  DNA Ligases: Progress and Prospects* , 2009, The Journal of Biological Chemistry.

[9]  J. Bartlett,et al.  Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[10]  D. Yan,et al.  Identification and characterization of an inhibitor specific to bacterial NAD+‐dependent DNA ligases , 2008, The FEBS journal.

[11]  Ashok Kumar Jha,et al.  NAD+‐dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis: Novel structure‐function relationship and identification of a specific inhibitor , 2007, Proteins.

[12]  D. Pompliano,et al.  Drugs for bad bugs: confronting the challenges of antibacterial discovery , 2007, Nature Reviews Drug Discovery.

[13]  D. Dube,et al.  Mycobacterium tuberculosis NAD+-dependent DNA ligase is selectively inhibited by glycosylamines compared with human DNA ligase I , 2005, Nucleic acids research.

[14]  R. Tripathi,et al.  NAD+-dependent DNA Ligase (Rv3014c) from Mycobacterium tuberculosis , 2005, Journal of Biological Chemistry.

[15]  G. Choi,et al.  A high-throughput resonance energy transfer assay for Staphylococcus aureus DNA ligase. , 2004, Analytical biochemistry.

[16]  T. Lampe,et al.  Specific and Potent Inhibition of NAD+-dependent DNA Ligase by Pyridochromanones* , 2003, Journal of Biological Chemistry.

[17]  Claudio Dalvit,et al.  NMR screening techniques in drug discovery and drug design , 2002 .

[18]  Genshi Zhao,et al.  Development of a fluorescence resonance energy transfer assay for measuring the activity of Streptococcus pneumoniae DNA ligase, an enzyme essential for DNA replication, repair, and recombination. , 2002, Analytical biochemistry.

[19]  Mary Jane Ferraro,et al.  Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically : approved standard , 2000 .

[20]  L. Tilley,et al.  Specific Inhibition of the Eubacterial DNA Ligase by Arylamino Compounds , 1999, Antimicrobial Agents and Chemotherapy.