Spatial transcriptomic patterns underlying regional vulnerability to amyloid-β and tau pathologies and their relationships to cognitive dysfunction in Alzheimer's disease
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O. Sporns | A. Saykin | S. Risacher | L. Apostolova | K. Nho | Yu-chien Wu | Qiuting Wen | Sujuan Gao | A. Oblak | F. Unverzagt | Meichen Yu | J. Brosch | M. Farlow | D. Clark | Rachael L. Deardorff | Sophia Wang | Rachael Deardorff
[1] D. Swaab,et al. Sex differences in hippocampal β-amyloid accumulation in the triple-transgenic mouse model of Alzheimer’s disease and the potential role of local estrogens , 2023, Frontiers in Neuroscience.
[2] Keith A. Johnson,et al. APOE effects on regional tau in preclinical Alzheimer’s disease , 2023, Molecular Neurodegeneration.
[3] Alec R. Chapman,et al. Correlated gene modules uncovered by high-precision single-cell transcriptomics , 2022, Proceedings of the National Academy of Sciences of the United States of America.
[4] K. Nho,et al. INPP5D inhibition attenuates amyloid pathology through the regulation of microglial functions. , 2022, Alzheimer's & Dementia.
[5] Thomas M. Morse,et al. PLD3 affects axonal spheroids and network defects in Alzheimer’s disease , 2022, Nature.
[6] Nicole S. McKay,et al. APOE ε4 genotype, amyloid-β, and sex interact to predict tau in regions of high APOE mRNA expression , 2022, Science Translational Medicine.
[7] Ben D. Fulcher,et al. Toward Best Practices for Imaging Transcriptomics of the Human Brain , 2022, Biological Psychiatry.
[8] D. Owen,et al. Alzheimer’s disease-related transcriptional sex differences in myeloid cells , 2022, Journal of Neuroinflammation.
[9] Charles J. Lynch,et al. Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression , 2022, Nature Communications.
[10] D. Arnaldi,et al. Brain atrophy in idiopathic REM sleep behaviour disorder is a sign of incipient synucleinopathy. , 2022, Brain : a journal of neurology.
[11] Keith A. Johnson,et al. Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes , 2022, Science Translational Medicine.
[12] O. Hansson,et al. Tau biomarkers in Alzheimer's disease: towards implementation in clinical practice and trials , 2022, The Lancet Neurology.
[13] Keith A. Johnson,et al. Menopause Status Moderates Sex Differences in Tau Burden: A Framingham PET Study , 2022, Annals of neurology.
[14] Jesse A. Brown,et al. Regional Aβ-tau interactions promote onset and acceleration of Alzheimer’s disease tau spreading , 2022, Neuron.
[15] Nick C Fox,et al. New insights into the genetic etiology of Alzheimer’s disease and related dementias , 2022, Nature Genetics.
[16] D. Eisenberg,et al. Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43 , 2022, Nature.
[17] B. Boeve,et al. Advances and controversies in frontotemporal dementia: diagnosis, biomarkers, and therapeutic considerations , 2022, The Lancet Neurology.
[18] D. Holtzman,et al. ApoE Cascade Hypothesis in the pathogenesis of Alzheimer’s disease and related dementias , 2022, Neuron.
[19] J. Qiu,et al. Connectome gradient dysfunction in major depression and its association with gene expression profiles and treatment outcomes , 2022, Molecular Psychiatry.
[20] L. Petrucelli,et al. Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases , 2022, Cell.
[21] A. Dagher,et al. Network structure and transcriptomic vulnerability shape atrophy in frontotemporal dementia , 2022, Brain : a journal of neurology.
[22] Melissa J. Green,et al. Cell type-specific manifestations of cortical thickness heterogeneity in schizophrenia , 2022, Molecular Psychiatry.
[23] A. Dagher,et al. Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns , 2021, Brain : a journal of neurology.
[24] D. J. Ardesch,et al. Statistical testing in transcriptomic‐neuroimaging studies: A how‐to and evaluation of methods assessing spatial and gene specificity , 2021, Human brain mapping.
[25] L. Demetrius,et al. Sex differences in Alzheimer’s disease: metabolic reprogramming and therapeutic intervention , 2021, Trends in Endocrinology & Metabolism.
[26] K. Fliessbach,et al. Clinico-genetic findings in 509 frontotemporal dementia patients , 2021, Molecular Psychiatry.
[27] S. Ramón y. Cajal,et al. Association of CD2AP neuronal deposits with Braak neurofibrillary stage in Alzheimer’s disease , 2021, Brain pathology.
[28] O. Sporns,et al. The human connectome in Alzheimer disease — relationship to biomarkers and genetics , 2021, Nature Reviews Neurology.
[29] F. Turkheimer,et al. Imaging transcriptomics: Convergent cellular, transcriptomic, and molecular neuroimaging signatures in the healthy adult human brain , 2021, bioRxiv.
[30] Ben D. Fulcher,et al. Overcoming false-positive gene-category enrichment in the analysis of spatially resolved transcriptomic brain atlas data , 2021, Nature Communications.
[31] Sterling C. Johnson,et al. Four distinct trajectories of tau deposition identified in Alzheimer’s disease , 2021, Nature Medicine.
[32] B. Mišić,et al. Mapping gene transcription and neurocognition across human neocortex , 2021, Nature Human Behaviour.
[33] J. Suckling,et al. Associations of Alzheimer’s disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration , 2021, Alzheimer's research & therapy.
[34] M. Mroczek,et al. Imaging Transcriptomics in Neurodegenerative Diseases , 2020, Journal of neuroimaging : official journal of the American Society of Neuroimaging.
[35] M. Pontecorvo,et al. The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects , 2020, Brain : a journal of neurology.
[36] Shannon L. Risacher,et al. Tau-related white-matter alterations along spatially selective pathways , 2020, NeuroImage.
[37] D. Holtzman,et al. Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis , 2020, Neuron.
[38] M. Kringelbach,et al. Dynamical consequences of regional heterogeneity in the brain’s transcriptional landscape , 2020, Science Advances.
[39] G. Rees,et al. Differences in network controllability and regional gene expression underlie hallucinations in Parkinson’s disease , 2020, Brain : a journal of neurology.
[40] A. Holmes,et al. Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder , 2020, Proceedings of the National Academy of Sciences.
[41] Daniel S. Margulies,et al. Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness , 2020, Science Advances.
[42] K. Nho,et al. INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia , 2020, Neurobiology of Disease.
[43] Keith A. Johnson,et al. Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline , 2020, Annals of neurology.
[44] B. Mišić,et al. Comparing spatial null models for brain maps , 2021, NeuroImage.
[45] Joakim Lundeberg,et al. Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease , 2020, Cell.
[46] L. Clasen,et al. Integrative structural, functional, and transcriptomic analyses of sex-biased brain organization in humans , 2020, Proceedings of the National Academy of Sciences.
[47] Ben D. Fulcher,et al. Genetic influences on hub connectivity of the human connectome , 2020, Nature Communications.
[48] J. Morris,et al. Sex-related Differences in Tau Positron Emission Tomography (PET) and the Effects of Hormone Therapy (HT). , 2020, Alzheimer disease and associated disorders.
[49] J. Trojanowski,et al. Protein transmission in neurodegenerative disease , 2020, Nature Reviews Neurology.
[50] W. Jagust,et al. Detecting earlier stages of amyloid deposition using PET in cognitively normal elderly adults , 2020, Neurology.
[51] Eileen F. Tallman,et al. Visual contrast sensitivity is associated with the presence of cerebral amyloid and tau deposition , 2020, Brain communications.
[52] L. Mucke,et al. Tau Reduction Prevents Key Features of Autism in Mouse Models , 2020, Neuron.
[53] G. Fricchione,et al. Early-Life Trauma Endophenotypes and Brain Circuit – Gene Expression Relationships in Functional Neurological (Conversion) Disorder , 2020, Molecular Psychiatry.
[54] D. Collier,et al. Transcriptional Signatures of Tau and Amyloid Neuropathology , 2020, Cell reports.
[55] Jesse A. Brown,et al. Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET , 2020, Science Translational Medicine.
[56] Peter B. Jones,et al. Schizotypy-Related Magnetization of Cortex in Healthy Adolescence Is Colocated With Expression of Schizophrenia-Related Genes , 2019, Biological Psychiatry.
[57] J. Trojanowski,et al. Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology , 2019, Neuron.
[58] A. Dagher,et al. Local vulnerability and global connectivity jointly shape neurodegenerative disease propagation , 2019, PLoS biology.
[59] R. Buckner,et al. The brain’s default network: updated anatomy, physiology and evolving insights , 2019, Nature Reviews Neuroscience.
[60] Sterling C. Johnson,et al. Sex differences in the genetic predictors of Alzheimer's pathology. , 2019, Brain : a journal of neurology.
[61] Benjamin Freeze,et al. Regional transcriptional architecture of Parkinson's disease pathogenesis and network spread. , 2019, Brain : a journal of neurology.
[62] A. Saykin,et al. Plasma amyloid beta levels are associated with cerebral amyloid and tau deposition , 2019, Alzheimer's & dementia.
[63] J. Rohrer,et al. An update on genetic frontotemporal dementia , 2019, Journal of Neurology.
[64] Keith A. Johnson,et al. Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults , 2019, JAMA neurology.
[65] Manolis Kellis,et al. Single-cell transcriptomic analysis of Alzheimer’s disease , 2019, Nature.
[66] Ameera X. Patel,et al. Conservative and disruptive modes of adolescent change in brain functional connectivity , 2019, bioRxiv.
[67] Michael D. Greicius,et al. A Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward , 2019, Neuron.
[68] Nick C Fox,et al. Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing , 2019, Nature Genetics.
[69] Ben D. Fulcher,et al. Bridging the Gap between Connectome and Transcriptome , 2019, Trends in Cognitive Sciences.
[70] Timothy J. Hohman,et al. Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk , 2019, Nature Genetics.
[71] E. Bullmore,et al. Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes , 2018, Proceedings of the National Academy of Sciences.
[72] J. Wiltfang,et al. The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease , 2018, Acta Neuropathologica.
[73] Linda J. C. van Waalwijk van Doorn,et al. Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers. , 2018, Journal of Alzheimer's disease : JAD.
[74] Quanzheng Li,et al. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex , 2018, Nature Medicine.
[75] W. Jagust. Imaging the evolution and pathophysiology of Alzheimer disease , 2018, Nature Reviews Neuroscience.
[76] Jorge Sepulcre,et al. Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain , 2018, Nature Communications.
[77] Haochang Shou,et al. On testing for spatial correspondence between maps of human brain structure and function , 2018, NeuroImage.
[78] Ben D. Fulcher,et al. A practical guide to linking brain-wide gene expression and neuroimaging data , 2018, NeuroImage.
[79] Jorge Sepulcre,et al. Molecular properties underlying regional vulnerability to Alzheimer’s disease pathology , 2018, Brain : a journal of neurology.
[80] A. Bernacchia,et al. Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography , 2018, Nature Neuroscience.
[81] Fenna M. Krienen,et al. Gene expression links functional networks across cortex and striatum , 2018, Nature Communications.
[82] Christopher G Schwarz,et al. Longitudinal tau PET in ageing and Alzheimer’s disease , 2018, Brain : a journal of neurology.
[83] A. Ripka. Faculty of 1000 evaluation for Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging. , 2018 .
[84] Jorge Sepulcre,et al. Structural tract alterations predict down-stream tau accumulation in amyloid positive older individuals , 2018, Nature Neuroscience.
[85] Peter B. Jones,et al. Morphometric Similarity Networks Detect Microscale Cortical Organization and Predict Inter-Individual Cognitive Variation , 2017, Neuron.
[86] Bin Zhang,et al. Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation , 2017, Nature Medicine.
[87] Shannon L. Risacher,et al. Alzheimer disease brain atrophy subtypes are associated with cognition and rate of decline , 2017, Neurology.
[88] Henrik Zetterberg,et al. Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity , 2017, Nature Communications.
[89] Edward T. Bullmore,et al. Synaptic and transcriptionally downregulated genes are associated with cortical thickness differences in autism , 2017, bioRxiv.
[90] W. Jagust,et al. Considerations and code for partial volume correcting [18F]-AV-1451 tau PET data , 2017, Data in brief.
[91] A. Fagan,et al. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy , 2017, Nature.
[92] William J. Jagust,et al. Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease , 2017, NeuroImage.
[93] Bess Frost,et al. A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies. , 2017, Trends in pharmacological sciences.
[94] Á. Pascual-Leone,et al. Brain circuit–gene expression relationships and neuroplasticity of multisensory cortices in blind children , 2017, Proceedings of the National Academy of Sciences.
[95] Cornelis J. Stam,et al. Selective impairment of hippocampus and posterior hub areas in Alzheimer’s disease: an MEG-based multiplex network study , 2017, Brain : a journal of neurology.
[96] J. Morris,et al. The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement , 2017, Alzheimer's & Dementia.
[97] Peter B. Jones,et al. Adolescent Tuning of Association Cortex in Human Structural Brain Networks , 2017, bioRxiv.
[98] René S. Kahn,et al. Connectome Disconnectivity and Cortical Gene Expression in Patients With Schizophrenia , 2017, Biological Psychiatry.
[99] A. Xie,et al. The Role of Reelin Signaling in Alzheimer’s Disease , 2016, Molecular Neurobiology.
[100] Knut Engedal,et al. Frontotemporal Dementia , 2016, Journal of geriatric psychiatry and neurology.
[101] S. Klein,et al. Sex differences in immune responses , 2016, Nature Reviews Immunology.
[102] S. Akyol,et al. Pathophysiological Function of ADAMTS Enzymes on Molecular Mechanism of Alzheimer's Disease. , 2016, Aging and disease.
[103] C. Gaiteri,et al. Genetic variants in Alzheimer disease — molecular and brain network approaches , 2016, Nature Reviews Neurology.
[104] Whitaker Kirstie. Validation cohort results for NSPN manuscript "Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome" , 2016 .
[105] Clifford R Jack,et al. Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults. , 2016, JAMA neurology.
[106] D. Selkoe,et al. A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration , 2016, Nature Reviews Neuroscience.
[107] Daniel R. Schonhaut,et al. PET Imaging of Tau Deposition in the Aging Human Brain , 2016, Neuron.
[108] Fenna M. Krienen,et al. Transcriptional profiles of supragranular-enriched genes associate with corticocortical network architecture in the human brain , 2016, Proceedings of the National Academy of Sciences.
[109] Allan R. Jones,et al. Canonical Genetic Signatures of the Adult Human Brain , 2015, Nature Neuroscience.
[110] M. Raichle. The brain's default mode network. , 2015, Annual review of neuroscience.
[111] E. Cadenas,et al. Perimenopause as a neurological transition state , 2015, Nature Reviews Endocrinology.
[112] M. Rietschel,et al. Correlated gene expression supports synchronous activity in brain networks , 2015, Science.
[113] Michael W. Weiner,et al. 2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception , 2015, Alzheimer's & Dementia.
[114] J. Trojanowski,et al. Spreading of pathology in neurodegenerative diseases: a focus on human studies , 2015, Nature Reviews Neuroscience.
[115] Allan R. Jones,et al. A mesoscale connectome of the mouse brain , 2014, Nature.
[116] Erick R. Scott,et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease , 2013, Nature.
[117] M. Mintun,et al. Comparing positron emission tomography imaging and cerebrospinal fluid measurements of β‐amyloid , 2013, Annals of neurology.
[118] M. Hattori,et al. A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS‐4) cleaves Reelin in an isoform‐dependent manner , 2012, FEBS letters.
[119] Allan R. Jones,et al. An anatomically comprehensive atlas of the adult human brain transcriptome , 2012, Nature.
[120] Santo Fortunato,et al. Consensus clustering in complex networks , 2012, Scientific Reports.
[121] Olga Peñagarikano,et al. What does CNTNAP2 reveal about autism spectrum disorder? , 2012, Trends in molecular medicine.
[122] Olaf Sporns,et al. Weight-conserving characterization of complex functional brain networks , 2011, NeuroImage.
[123] Frank Z. Stanczyk,et al. Sex differences in β-amyloid accumulation in 3xTg-AD mice: Role of neonatal sex steroid hormone exposure , 2010, Brain Research.
[124] Olaf Sporns,et al. Complex network measures of brain connectivity: Uses and interpretations , 2010, NeuroImage.
[125] A. Fagan,et al. APOE predicts amyloid‐beta but not tau Alzheimer pathology in cognitively normal aging , 2010, Annals of neurology.
[126] Nick C Fox,et al. The heritability and genetics of frontotemporal lobar degeneration , 2009, Neurology.
[127] Jinyan Li,et al. Maximization of negative correlations in time-course gene expression data for enhancing understanding of molecular pathways , 2009, Nucleic acids research.
[128] J. Trojanowski,et al. Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies , 2009, Nature Reviews Drug Discovery.
[129] Keith A. Johnson,et al. Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia , 2009, Neuron.
[130] Keith A. Johnson,et al. Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease , 2009, The Journal of Neuroscience.
[131] W. Seeley,et al. Selective functional, regional, and neuronal vulnerability in frontotemporal dementia , 2008, Current opinion in neurology.
[132] Jean-Loup Guillaume,et al. Fast unfolding of communities in large networks , 2008, 0803.0476.
[133] J. Trojanowski,et al. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders , 2007, Nature Reviews Neuroscience.
[134] M. Hutton,et al. The genetics of frontotemporal dementia. , 2007, Neurologic clinics.
[135] A. Saykin,et al. Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI , 2006, Neurology.
[136] Anders M. Dale,et al. An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest , 2006, NeuroImage.
[137] M. Mattson,et al. Ageing and neuronal vulnerability , 2006, Nature Reviews Neuroscience.
[138] S. Tabrizi,et al. Biomarkers for neurodegenerative diseases , 2005, Current opinion in neurology.
[139] Pablo Tamayo,et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[140] Adriana B Ferreira,et al. Agrin Differentially Regulates the Rates of Axonal and Dendritic Elongation in Cultured Hippocampal Neurons , 2001, The Journal of Neuroscience.
[141] D. Botstein,et al. Genomic expression programs in the response of yeast cells to environmental changes. , 2000, Molecular biology of the cell.
[142] C. Strickland,et al. Correspondence , 1932, The Indian medical gazette.
[143] Yang Yang,et al. Age-dependent formation of TMEM106B amyloid filaments in human brains , 2022, Nature.
[144] M. van Dijk,et al. Direct downregulation of CNTNAP2 by STOX1A is associated with Alzheimer's disease. , 2012, Journal of Alzheimer's disease : JAD.
[145] J. Trojanowski,et al. Neurodegenerative tauopathies. , 2001, Annual review of neuroscience.