Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus

[1]  Wenqing Xu,et al.  Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme , 2007, Nature.

[2]  I. Grundke‐Iqbal,et al.  Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration , 2007, The European journal of neuroscience.

[3]  Yigong Shi,et al.  Structure of the Protein Phosphatase 2A Holoenzyme , 2006, Cell.

[4]  G. Weaving,et al.  Behavioural and Psychological Symptoms of Alzheimer Type Dementia Are Not Correlated with Plasma Homocysteine Concentration , 2006, Dementia and Geriatric Cognitive Disorders.

[5]  L. Gustafson,et al.  Plasma Homocysteine, Cobalamin/Folate Status, and Vascular Disease in a Large Population of Psychogeriatric Patients , 2006, Dementia and Geriatric Cognitive Disorders.

[6]  Ying-Hua Liu,et al.  Peroxynitrite induces Alzheimer‐like tau modifications and accumulation in rat brain and its underlying mechanisms , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[7]  M. Pappolla,et al.  Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid β peptide levels , 2006, Neurobiology of Disease.

[8]  R. Obeid,et al.  Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia , 2006, FEBS letters.

[9]  J. Götz,et al.  Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice. , 2006, Biochemical and biophysical research communications.

[10]  C. Gong,et al.  Concurrent alterations of O‐GlcNAcylation and phosphorylation of tau in mouse brains during fasting , 2006, The European journal of neuroscience.

[11]  L. Whalley,et al.  Long-term homocysteine exposure induces alterations in spatial learning, hippocampal signalling and synaptic plasticity , 2006, Experimental Neurology.

[12]  Fei Liu,et al.  Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation , 2005, The European journal of neuroscience.

[13]  B. Winblad,et al.  Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms , 2005, Journal of neurochemistry.

[14]  E. Porcellini,et al.  Homocysteine and folate as risk factors for dementia and Alzheimer disease , 2005 .

[15]  C. Gong,et al.  Injection of okadaic acid into the meynert nucleus basalis of rat brain induces decreased acetylcholine level and spatial memory deficit , 2004, Neuroscience.

[16]  I. Grundke‐Iqbal,et al.  Tau Becomes a More Favorable Substrate for GSK-3 When It Is Prephosphorylated by PKA in Rat Brain* , 2004, Journal of Biological Chemistry.

[17]  C. White,et al.  Downregulation of Protein Phosphatase 2A Carboxyl Methylation and Methyltransferase May Contribute to Alzheimer Disease Pathogenesis , 2004, Journal of neuropathology and experimental neurology.

[18]  Jesús Avila,et al.  Glycogen synthase kinase 3: a drug target for CNS therapies , 2004, Journal of neurochemistry.

[19]  Hwayoung Lee,et al.  Effects of dietary folic acid supplementation on cerebrovascular endothelial dysfunction in rats with induced hyperhomocysteinemia , 2004, Brain Research.

[20]  T. Murohara,et al.  Rescue of hypercholesterolemia-related impairment of angiogenesis by oral folate supplementation. , 2003, Journal of the American College of Cardiology.

[21]  R. Liu,et al.  Inhibition of protein phosphatase 2A- and protein phosphatase 1-induced tau hyperphosphorylation and impairment of spatial memory retention in rats , 2003, Neuroscience.

[22]  D. Fuchs,et al.  Rapid measurement of total plasma homocysteine by HPLC. , 2003, Clinica chimica acta; international journal of clinical chemistry.

[23]  M. Mattson,et al.  Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders , 2003, Trends in Neurosciences.

[24]  Hwayoung Lee,et al.  Hyperhomocysteinemia due to short-term folate deprivation is related to electron microscopic changes in the rat brain. , 2002, The Journal of nutrition.

[25]  Qing Tian,et al.  Role of Serine/Threonine Protein Phosphatase in Alzheimer’s Disease , 2002, Neurosignals.

[26]  J. Stock,et al.  Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease , 2002, FEBS letters.

[27]  D. R. Close,et al.  The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer’s disease , 2002, Neurobiology of Aging.

[28]  M. Mattson,et al.  Folic Acid Deficiency and Homocysteine Impair DNA Repair in Hippocampal Neurons and Sensitize Them to Amyloid Toxicity in Experimental Models of Alzheimer's Disease , 2002, The Journal of Neuroscience.

[29]  Sudha Seshadri,et al.  Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease , 2002 .

[30]  F. Eberli,et al.  Decreased rate of coronary restenosis after lowering of plasma homocysteine levels. , 2001, The New England journal of medicine.

[31]  S. Fujita,et al.  Inhibition of Protein Phosphatase 2A Overrides Tau Protein Kinase I/Glycogen Synthase Kinase 3β and Cyclin-dependent Kinase 5 Inhibition and Results in Tau Hyperphosphorylation in the Hippocampus of Starved Mouse* , 2001, The Journal of Biological Chemistry.

[32]  J. Trojanowski,et al.  PP2A mRNA Expression Is Quantitatively Decreased in Alzheimer's Disease Hippocampus , 2001, Experimental Neurology.

[33]  V. Janssens,et al.  Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. , 2001, The Biochemical journal.

[34]  J. Broach,et al.  Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo , 2000, The EMBO journal.

[35]  J. Stock,et al.  Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits , 2000, The EMBO journal.

[36]  J. Wegiel,et al.  Phosphorylation of Microtubule-associated Protein Tau Is Regulated by Protein Phosphatase 2A in Mammalian Brain , 2000, The Journal of Biological Chemistry.

[37]  G. Bloom,et al.  Molecular Interactions among Protein Phosphatase 2A, Tau, and Microtubules , 1999, The Journal of Biological Chemistry.

[38]  B. Wadzinski,et al.  Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit. , 1999, The Biochemical journal.

[39]  R Clarke,et al.  Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. , 1998, Archives of neurology.

[40]  J. Loscalzo,et al.  Homocysteine and atherothrombosis. , 1998, The New England journal of medicine.

[41]  A. McCaddon,et al.  Total serum homocysteine in senile dementia of Alzheimer type , 1998, International journal of geriatric psychiatry.

[42]  J. Trojanowski,et al.  Selective Destruction of Stable Microtubules and Axons by Inhibitors of Protein Serine/Threonine Phosphatases in Cultured Human Neurons (NT2N Cells) , 1997, The Journal of Neuroscience.

[43]  G. Bloom,et al.  Regulation of the Phosphorylation State and Microtubule-Binding Activity of Tau by Protein Phosphatase 2A , 1996, Neuron.

[44]  J. Stock,et al.  A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[45]  J. Trojanowski,et al.  Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[46]  D. Brautigan Flicking the switches: phosphorylation of serine/threonine protein phosphatases. , 1995, Seminars in cancer biology.

[47]  I. Grundke‐Iqbal,et al.  Phosphatase Activity Toward Abnormally Phosphorylated τ: Decrease in Alzheimer Disease Brain , 1995, Journal of neurochemistry.

[48]  I. Grundke‐Iqbal,et al.  Dephosphorylation of Alzheimer Paired Helical Filaments by Protein Phosphatase-2A and −2B (*) , 1995, The Journal of Biological Chemistry.

[49]  R. D'Agostino,et al.  Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. , 1995, The New England journal of medicine.

[50]  T. Iwatsubo,et al.  Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43) , 1994, Neuron.

[51]  I. Grundke‐Iqbal,et al.  Alzheimer's Disease Abnormally Phosphorylated τ Is Dephosphorylated by Protein Phosphatase‐2B (Calcineurin) , 1994, Journal of neurochemistry.

[52]  M. Goedert Tau protein and the neurofibrillary pathology of Alzheimer's disease , 1993, Trends in Neurosciences.

[53]  J. Stock,et al.  Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferase. , 1993, The Journal of biological chemistry.

[54]  I. Grundke‐Iqbal,et al.  Phosphoprotein Phosphatase Activities in Alzheimer Disease Brain , 1993, Journal of neurochemistry.

[55]  H. Karlinsky,et al.  Folate, vitamin B12 and cognitive impairment in patients with Alzheimer's disease , 1992, Acta psychiatrica Scandinavica.

[56]  J. Trojanowski,et al.  A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. , 1991, Science.

[57]  Khadija Iqbal,et al.  Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[58]  H. Wiśniewski,et al.  Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[59]  H. Wiśniewski,et al.  Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. , 1986, The Journal of biological chemistry.

[60]  D. Pallas,et al.  Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen. , 2001, Molecular biology of the cell.

[61]  E. Sontag Protein phosphatase 2A: the Trojan Horse of cellular signaling. , 2001, Cellular signalling.