Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus
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Dao-Wen Wang | Xinwen Zhou | Q. Tian | Jian-Zhi Wang | Qun Wang | Gong-Ping Liu | Chang-E. Zhang | Wei Wei | Jun Peng | Daowen Wang
[1] Wenqing Xu,et al. Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme , 2007, Nature.
[2] I. Grundke‐Iqbal,et al. Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration , 2007, The European journal of neuroscience.
[3] Yigong Shi,et al. Structure of the Protein Phosphatase 2A Holoenzyme , 2006, Cell.
[4] G. Weaving,et al. Behavioural and Psychological Symptoms of Alzheimer Type Dementia Are Not Correlated with Plasma Homocysteine Concentration , 2006, Dementia and Geriatric Cognitive Disorders.
[5] L. Gustafson,et al. Plasma Homocysteine, Cobalamin/Folate Status, and Vascular Disease in a Large Population of Psychogeriatric Patients , 2006, Dementia and Geriatric Cognitive Disorders.
[6] Ying-Hua Liu,et al. Peroxynitrite induces Alzheimer‐like tau modifications and accumulation in rat brain and its underlying mechanisms , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[7] M. Pappolla,et al. Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid β peptide levels , 2006, Neurobiology of Disease.
[8] R. Obeid,et al. Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia , 2006, FEBS letters.
[9] J. Götz,et al. Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice. , 2006, Biochemical and biophysical research communications.
[10] C. Gong,et al. Concurrent alterations of O‐GlcNAcylation and phosphorylation of tau in mouse brains during fasting , 2006, The European journal of neuroscience.
[11] L. Whalley,et al. Long-term homocysteine exposure induces alterations in spatial learning, hippocampal signalling and synaptic plasticity , 2006, Experimental Neurology.
[12] Fei Liu,et al. Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation , 2005, The European journal of neuroscience.
[13] B. Winblad,et al. Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms , 2005, Journal of neurochemistry.
[14] E. Porcellini,et al. Homocysteine and folate as risk factors for dementia and Alzheimer disease , 2005 .
[15] C. Gong,et al. Injection of okadaic acid into the meynert nucleus basalis of rat brain induces decreased acetylcholine level and spatial memory deficit , 2004, Neuroscience.
[16] I. Grundke‐Iqbal,et al. Tau Becomes a More Favorable Substrate for GSK-3 When It Is Prephosphorylated by PKA in Rat Brain* , 2004, Journal of Biological Chemistry.
[17] C. White,et al. Downregulation of Protein Phosphatase 2A Carboxyl Methylation and Methyltransferase May Contribute to Alzheimer Disease Pathogenesis , 2004, Journal of neuropathology and experimental neurology.
[18] Jesús Avila,et al. Glycogen synthase kinase 3: a drug target for CNS therapies , 2004, Journal of neurochemistry.
[19] Hwayoung Lee,et al. Effects of dietary folic acid supplementation on cerebrovascular endothelial dysfunction in rats with induced hyperhomocysteinemia , 2004, Brain Research.
[20] T. Murohara,et al. Rescue of hypercholesterolemia-related impairment of angiogenesis by oral folate supplementation. , 2003, Journal of the American College of Cardiology.
[21] R. Liu,et al. Inhibition of protein phosphatase 2A- and protein phosphatase 1-induced tau hyperphosphorylation and impairment of spatial memory retention in rats , 2003, Neuroscience.
[22] D. Fuchs,et al. Rapid measurement of total plasma homocysteine by HPLC. , 2003, Clinica chimica acta; international journal of clinical chemistry.
[23] M. Mattson,et al. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders , 2003, Trends in Neurosciences.
[24] Hwayoung Lee,et al. Hyperhomocysteinemia due to short-term folate deprivation is related to electron microscopic changes in the rat brain. , 2002, The Journal of nutrition.
[25] Qing Tian,et al. Role of Serine/Threonine Protein Phosphatase in Alzheimer’s Disease , 2002, Neurosignals.
[26] J. Stock,et al. Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease , 2002, FEBS letters.
[27] D. R. Close,et al. The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer’s disease , 2002, Neurobiology of Aging.
[28] M. Mattson,et al. Folic Acid Deficiency and Homocysteine Impair DNA Repair in Hippocampal Neurons and Sensitize Them to Amyloid Toxicity in Experimental Models of Alzheimer's Disease , 2002, The Journal of Neuroscience.
[29] Sudha Seshadri,et al. Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease , 2002 .
[30] F. Eberli,et al. Decreased rate of coronary restenosis after lowering of plasma homocysteine levels. , 2001, The New England journal of medicine.
[31] S. Fujita,et al. Inhibition of Protein Phosphatase 2A Overrides Tau Protein Kinase I/Glycogen Synthase Kinase 3β and Cyclin-dependent Kinase 5 Inhibition and Results in Tau Hyperphosphorylation in the Hippocampus of Starved Mouse* , 2001, The Journal of Biological Chemistry.
[32] J. Trojanowski,et al. PP2A mRNA Expression Is Quantitatively Decreased in Alzheimer's Disease Hippocampus , 2001, Experimental Neurology.
[33] V. Janssens,et al. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. , 2001, The Biochemical journal.
[34] J. Broach,et al. Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo , 2000, The EMBO journal.
[35] J. Stock,et al. Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits , 2000, The EMBO journal.
[36] J. Wegiel,et al. Phosphorylation of Microtubule-associated Protein Tau Is Regulated by Protein Phosphatase 2A in Mammalian Brain , 2000, The Journal of Biological Chemistry.
[37] G. Bloom,et al. Molecular Interactions among Protein Phosphatase 2A, Tau, and Microtubules , 1999, The Journal of Biological Chemistry.
[38] B. Wadzinski,et al. Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit. , 1999, The Biochemical journal.
[39] R Clarke,et al. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. , 1998, Archives of neurology.
[40] J. Loscalzo,et al. Homocysteine and atherothrombosis. , 1998, The New England journal of medicine.
[41] A. McCaddon,et al. Total serum homocysteine in senile dementia of Alzheimer type , 1998, International journal of geriatric psychiatry.
[42] J. Trojanowski,et al. Selective Destruction of Stable Microtubules and Axons by Inhibitors of Protein Serine/Threonine Phosphatases in Cultured Human Neurons (NT2N Cells) , 1997, The Journal of Neuroscience.
[43] G. Bloom,et al. Regulation of the Phosphorylation State and Microtubule-Binding Activity of Tau by Protein Phosphatase 2A , 1996, Neuron.
[44] J. Stock,et al. A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[45] J. Trojanowski,et al. Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[46] D. Brautigan. Flicking the switches: phosphorylation of serine/threonine protein phosphatases. , 1995, Seminars in cancer biology.
[47] I. Grundke‐Iqbal,et al. Phosphatase Activity Toward Abnormally Phosphorylated τ: Decrease in Alzheimer Disease Brain , 1995, Journal of neurochemistry.
[48] I. Grundke‐Iqbal,et al. Dephosphorylation of Alzheimer Paired Helical Filaments by Protein Phosphatase-2A and −2B (*) , 1995, The Journal of Biological Chemistry.
[49] R. D'Agostino,et al. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. , 1995, The New England journal of medicine.
[50] T. Iwatsubo,et al. Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43) , 1994, Neuron.
[51] I. Grundke‐Iqbal,et al. Alzheimer's Disease Abnormally Phosphorylated τ Is Dephosphorylated by Protein Phosphatase‐2B (Calcineurin) , 1994, Journal of neurochemistry.
[52] M. Goedert. Tau protein and the neurofibrillary pathology of Alzheimer's disease , 1993, Trends in Neurosciences.
[53] J. Stock,et al. Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferase. , 1993, The Journal of biological chemistry.
[54] I. Grundke‐Iqbal,et al. Phosphoprotein Phosphatase Activities in Alzheimer Disease Brain , 1993, Journal of neurochemistry.
[55] H. Karlinsky,et al. Folate, vitamin B12 and cognitive impairment in patients with Alzheimer's disease , 1992, Acta psychiatrica Scandinavica.
[56] J. Trojanowski,et al. A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. , 1991, Science.
[57] Khadija Iqbal,et al. Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[58] H. Wiśniewski,et al. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[59] H. Wiśniewski,et al. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. , 1986, The Journal of biological chemistry.
[60] D. Pallas,et al. Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen. , 2001, Molecular biology of the cell.
[61] E. Sontag. Protein phosphatase 2A: the Trojan Horse of cellular signaling. , 2001, Cellular signalling.