99Tcm HMPAO SPECT in progressive multifocal leucoencephalopathy.

Progressive multifocal leucoencephalopathy (PML), a rare condition caused by the JC papovavirus, is characterized by multiple areas of demyelination within the central nervous system. It almost always occurs in the context of immunosuppression and as a result of AIDS the number of cases has increased (Levy et al, 1988; Lang et al, 1989). Both computed tomography (CT) scanning and magnetic resonance imaging (MRI) have been found to be of limited value in establishing the diagnosis of PML. An alternative technique that might support a clinical diagnosis of PML would therefore be valuable, particularly if it would avoid the need to proceed to biopsy. We report a case of biopsy proven PML investigated by single photon emission computerized tomography (SPECT) using 99Tcm hexamethylpropyleneamineoxime (99Tcm HMPAO).

[1]  J. Lee,et al.  Controversy in the MR imaging appearance of fibrosis. , 1990, Radiology.

[2]  M. Mauro,et al.  Gadolinium-DTPA enhancement of lung radiation fibrosis. , 1989, Journal of computer assisted tomography.

[3]  M. Williams,et al.  Simple nontoxic treatment of advanced metastatic seminoma with carboplatin. , 1989, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[4]  N. Just,et al.  Progressive Multifocal Leukoencephalopathy with Gray Matter Involvement , 1989, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[5]  W. Kucharczyk,et al.  MRI of the floor of the mouth, tongue and orohypopharynx. , 1989, Radiologic clinics of North America.

[6]  A. Alavi,et al.  Positron emission tomography in a patient with progressive multifocal leukoencephalopathy , 1988, Neurology.

[7]  J. Doppman,et al.  Short-Ti inversion-recovery pulse sequence: analysis and initial experience in cancer imaging. , 1988, Radiology.

[8]  A. Sagalowsky,et al.  Uncommon sites of recurrent seminoma and implications for therapy , 1986, Cancer.

[9]  J. Husband,et al.  Unusual thoracoabdominal sites of metastases in testicular tumors. , 1985, AJR. American journal of roentgenology.

[10]  N. Leeds,et al.  Progressive multifocal leukoencephalopathy: Clinical and radiographic features , 1985, Annals of neurology.

[11]  W. Whitmore,et al.  Autopsy findings in 154 patients with germ cell tumors of the testis , 1982, Cancer.

[12]  J. Rush,et al.  Testicular seminoma metastatic to the orbit. , 1981, American journal of ophthalmology.

[13]  D. Bredesen,et al.  Central nervous system dysfunction in acquired immunodeficiency syndrome. , 1988, Journal of acquired immune deficiency syndromes.

[14]  R. Janssen,et al.  Neuroepidemiology of acquired immunodeficiency syndrome. , 1988, Journal of acquired immune deficiency syndromes.

[15]  P. Averback,et al.  Metastatic intracranial seminoma. , 1979, Archives of neurology.