Cross Correlation Studies in Primate Motor Cortex: Event Related Correlation

Simultaneous extracellular unit recordings were made from each cell of 237 pairs in two awake monkeys, during a voluntary reaching movement of the forelimb. The cells were located in contralateral precentral cortex and functionally coupled to single forelimb joints, as indicated by intracortical microstimulation and passive sensory stimulation. Cross correlation analysis showed that 72 of these pairs exhibited significant event-related correlation over periods of up to 780 ms, comparable to and coincident with the forelimb movement. Spatial analysis showed that such correlation extended across contiguous portions of all four forelimb joint zones of precentral cortex, over distances up to 3.5 mm. No preferred direction of correlation was observed. The data confirm the previously described nested organization of the forelimb area of precentral cortex. Findings are discussed in terms of mechanisms by which columns of neurons in motor cortex participate in the reaching movement.

[1]  G L Gerstein,et al.  Favored patterns in spike trains. II. Application. , 1983, Journal of neurophysiology.

[2]  G. P. Moore,et al.  Neuronal spike trains and stochastic point processes. II. Simultaneous spike trains. , 1967, Biophysical journal.

[3]  H Asanuma,et al.  Recent developments in the study of the columnar arrangement of neurons within the motor cortex. , 1975, Physiological reviews.

[4]  J. Murphy,et al.  Sequential activation of neurons in primate motor cortex during unrestrained forelimb movement. , 1985, Journal of neurophysiology.

[5]  Marcus E. Raichle,et al.  Quantitative in vivo autoradiography with positron emission tomography , 1979, Brain Research Reviews.

[6]  G. P. Moore,et al.  Statistical signs of synaptic interaction in neurons. , 1970, Biophysical journal.

[7]  J. T. Murphy,et al.  Distribution of responses to visual cues for movement in precentral cortex of awake primates , 1981, Neuroscience Letters.

[8]  R. Lemon.  Functional properties of monkey motor cortex neurones receiving afferent input from the hand and fingers , 1981, The Journal of physiology.

[9]  Y. Lamarre,et al.  Fast ballistic arm movements triggered by visual, auditory, and somesthetic stimuli in the monkey. I. Activity of precentral cortical neurons. , 1983, Journal of neurophysiology.

[10]  J. Murphy,et al.  Temporal characteristics of torque-triggered neuronal responses in primate precentral cortex , 1980 .

[11]  A. Towe,et al.  Somatosensory Cortex: Descending Influences on Ascending Systems , 1973 .

[12]  Donald L. Harnett,et al.  Introduction to statistical methods , 1970 .

[13]  J. Murphy,et al.  Spatial organization of precentral cortex in awake primates. III. Input-output coupling. , 1978, Journal of neurophysiology.

[14]  V. Hömberg,et al.  Event‐Related Changes of Fast Rhythmic EEG Activity in a Positioning Movement Task a , 1984, Annals of the New York Academy of Sciences.

[15]  L. Sokoloff,et al.  RELATION BETWEEN PHYSIOLOGICAL FUNCTION AND ENERGY METABOLISM IN THE CENTRAL NERVOUS SYSTEM , 1977, Journal of neurochemistry.

[16]  G L Gerstein,et al.  Interactions between neurons in auditory cortex of the cat. , 1974, Journal of neurophysiology.

[17]  Amiram Grinvald,et al.  Real-time optical imaging of neuronal activity , 1984, Trends in Neurosciences.

[18]  H C Kwan,et al.  Spatial organization of precentral cortex in awake primates. II. Motor outputs. , 1978, Journal of neurophysiology.

[19]  J. Murphy,et al.  Physiologic Basis for Focal Motor Seizures and the Jacksonian “March” Phenomena , 1980, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[20]  W G Tatton,et al.  Analysis of postural motoneuron activity in crayfish abdomen. II. Coordination by excitatory and inhibitory connections between motoneurons. , 1975, Journal of neurophysiology.

[21]  J. Murphy,et al.  Spatial organization of precentral cortex in awake primates. I. Somatosensory inputs. , 1978, Journal of neurophysiology.

[22]  H. C. Kwan,et al.  Activity of primate precentral neurons during voluntary movements triggered by visual signals , 1982, Brain Research.

[23]  S. Williamson.  MAGNETIC LOCATION OF CORTICAL ACTIVITY * , 1980 .

[24]  P. Roland,et al.  Different cortical areas in man in organization of voluntary movements in extrapersonal space. , 1980, Journal of neurophysiology.

[25]  J. T. Murphy,et al.  Cross Correlation Studies in Primate Motor Cortex: Synaptic Interaction and Shared Input , 1985, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[26]  David R. Cox,et al.  The statistical analysis of series of events , 1966 .

[27]  J. Murphy,et al.  Precentral unit activity correlated with angular components of a compound arm movement , 1982, Brain Research.

[28]  J. H. J. Allum,et al.  Cross-correlation analysis of interneuronal connectivity in the motor cortex of the monkey , 1982, Brain Research.