Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis

We studied the effect of vitamin C, vitamin E, and beta carotene intake on the risk of Parkinson's disease (PD). We did a systematic review and meta-analysis of observational studies published between 1966 and March 2005 searching MEDLINE, EMBASE, and the Cochrane Library. Eight studies were identified (six case-control, one cohort, and one cross-sectional). We found that dietary intake of vitamin E protects against PD. This protective influence was seen with both moderate intake (relative risk 0.81, 95% CI 0.67-0.98) and high intake (0.78, 0.57-1.06) of vitamin E, although the possible benefit associated with high intake of vitamin E was not significant. The studies did not suggest any protective effects associated with vitamin C or beta carotene. We conclude that dietary vitamin E may have a neuroprotective effect attenuating the risk of PD. These results require confirmation in randomised controlled trials.

[1]  D Spiegelman,et al.  Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk , 2002, Neurology.

[2]  H Checkoway,et al.  Dietary factors in Parkinson's disease: The role of food groups and specific foods , 1999, Movement disorders : official journal of the Movement Disorder Society.

[3]  D. Spiegelman,et al.  Evaluation of old and new tests of heterogeneity in epidemiologic meta-analysis. , 1999, American journal of epidemiology.

[4]  M. Beal.  Mitochondria, Oxidative Damage, and Inflammation in Parkinson's Disease , 2003, Annals of the New York Academy of Sciences.

[5]  W. Stahl,et al.  Antioxidant Functions of Vitamins , 1992, Annals of the New York Academy of Sciences.

[6]  C. Olanow.  Dietary vitamin E and Parkinson's disease: something to chew on , 2003, The Lancet Neurology.

[7]  A. Paganini-Hill.  Risk Factors for Parkinson’s Disease: The Leisure World Cohort Study , 2001, Neuroepidemiology.

[8]  A. M. Walker,et al.  Odd man out: a graphical approach to meta-analysis. , 1988, American journal of public health.

[9]  I. Shoulson,et al.  On-off effects in Parkinson's disease: a controlled investigation of ascorbic acid therapy. , 1983, Advances in neurology.

[10]  A. Lees,et al.  Ageing and Parkinson's disease: substantia nigra regional selectivity. , 1991, Brain : a journal of neurology.

[11]  D. Morens,et al.  Case‐control study of idiopathic Parkinson's disease and dietary vitamin E intake , 1996, Neurology.

[12]  M. Brin,et al.  Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. , 1993, The New England journal of medicine.

[13]  J. Kordower,et al.  Etiology of Parkinson's disease: Genetics and environment revisited , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[14]  C. C. Johnson,et al.  Adult nutrient intake as a risk factor for Parkinson's disease. , 1999, International journal of epidemiology.

[15]  G. Ulm,et al.  Diet and Parkinson's disease II , 1996, Neurology.

[16]  C. Clarke.  A “cure” for Parkinson's disease: Can neuroprotection be proven with current trial designs? , 2004, Movement disorders : official journal of the Movement Disorder Society.

[17]  A. Schapira,et al.  Neuroprotection in Parkinson disease: mysteries, myths, and misconceptions. , 2004, JAMA.

[18]  M. Rice.  Ascorbate regulation and its neuroprotective role in the brain , 2000, Trends in Neurosciences.

[19]  K. Gwinn‐Hardy,et al.  The role of radiotracer imaging in Parkinson disease , 2005, Neurology.

[20]  J. Freudenheim,et al.  Dietary antioxidants and other dietary factors in the etiology of Parkinson's disease , 1997, Movement disorders : official journal of the Movement Disorder Society.

[21]  L. Manzino,et al.  Ascorbic Acid, Redox Cycling, Lipid Peroxidation, and the Binding of Dopamine Receptor Antagonists a , 1987, Annals of the New York Academy of Sciences.

[22]  Carmen Cadarso-Suárez,et al.  HEpiMA: software for the identification of heterogeneity in meta-analysis , 2001, Comput. Methods Programs Biomed..

[23]  C. Tanner,et al.  Levodopa and the progression of Parkinson's disease. , 2004, The New England journal of medicine.

[24]  S. Lie,et al.  Mortality and Parkinson disease , 2004, Neurology.

[25]  A. Hofman,et al.  Dietary antioxidants and Parkinson disease. The Rotterdam Study. , 1997, Archives of neurology.