BEHAVIOR OF SERUM ADENOSINE DEAMINASE AND ITS ISOENZYMES IN PATIENTS WITH URTICARIA

Urticaria is a complex inflammatory disease, with often unidentified causes and incompletely elucidated etiopathogenic mechanisms. The purpose of the paper is to determine the serum profile of adenosine deaminases (total ADA, ADA-1, ADA-2), endogenous mediators possibly involved in the persistence and resolution of spontaneous urticaria. Based on the enzymatic activities determined in 84 patients with spontaneous acute urticaria, 60 patients with spontaneous chronic urticaria and 64 healthy volunteers, it was found that: two ADA-1 and ADA-2 isoenzymes were detected in the human serum, based on which the two types of urticaria can be differentiated. The authors acknowledge that modulation of adenosine deaminase activity could influence urticaria resolution.

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