LARP4A and LARP4B in cancer: The new kids on the block.

[1]  A. Gartland,et al.  The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis , 2023, bioRxiv.

[2]  Liangjie Sun,et al.  PCB: A pseudotemporal causality-based Bayesian approach to identify EMT-associated regulatory relationships of AS events and RBPs during breast cancer progression , 2023, PLoS Comput. Biol..

[3]  Yi Wang,et al.  CircBNC2 affects epithelial ovarian cancer progression through the miR-223-3p/LARP4 axis , 2022, Anti-cancer drugs.

[4]  K. Cao,et al.  Comprehensive development and validation of gene signature for predicting survival in patients with glioblastoma , 2022, Frontiers in Genetics.

[5]  M. Lleonart,et al.  Targeting the "undruggable": RNA-binding proteins in the spotlight in cancer therapy. , 2022, Seminars in cancer biology.

[6]  Kun Zhang,et al.  A transcriptomic signature for prostate cancer relapse prediction identified from the differentially expressed genes between TP53 mutant and wild-type tumors , 2022, Scientific Reports.

[7]  Hong-Tao Zhang,et al.  RNA-binding Proteins and Cancer Metastasis. , 2022, Seminars in cancer biology.

[8]  Fei Ge,et al.  Research progress on RNA-binding proteins in breast cancer , 2022, Frontiers in Oncology.

[9]  J. Kjems,et al.  The emerging roles of circRNAs in cancer and oncology , 2021, Nature Reviews Clinical Oncology.

[10]  Q. Guo,et al.  The RNA-Binding Motif Protein Family in Cancer: Friend or Foe? , 2021, Frontiers in Oncology.

[11]  L. Jave-Suárez,et al.  CELF Family Proteins in Cancer: Highlights on the RNA-Binding Protein/Noncoding RNA Regulatory Axis , 2021, International journal of molecular sciences.

[12]  M. Taheri,et al.  Stress Granules Involved in Formation, Progression and Metastasis of Cancer: A Scoping Review , 2021, Frontiers in Cell and Developmental Biology.

[13]  A. Thomas-Tikhonenko,et al.  RNA-binding proteins of COSMIC importance in cancer. , 2021, The Journal of clinical investigation.

[14]  Zhuohui Chen,et al.  Identification and validation of RNA‐binding protein‐related gene signature revealed potential associations with immunosuppression and drug sensitivity in glioma , 2021, Cancer medicine.

[15]  J. Fournié,et al.  Cancer cell adaptability: turning ribonucleoprotein granules into targets. , 2021, Trends in cancer.

[16]  Cynthia A. Reinhart-King,et al.  Mechanoresponsive metabolism in cancer cell migration and metastasis. , 2021, Cell metabolism.

[17]  W. Cho,et al.  The oncogenic and tumor suppressive roles of RNA‐binding proteins in human cancers , 2021, Journal of cellular physiology.

[18]  G. Kozlov,et al.  LARP1 and LARP4: up close with PABP for mRNA 3’ poly(A) protection and stabilization , 2021, RNA biology.

[19]  J. Valcárcel,et al.  RNA-binding proteins in human genetic disease , 2020, Nature reviews. Genetics.

[20]  Donghee Kang,et al.  RNA-Binding Proteins in Cancer: Functional and Therapeutic Perspectives , 2020, Cancers.

[21]  Tianwei Li,et al.  Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails , 2020, eLife.

[22]  Xiaoxiao Xu,et al.  Circular RNA La-Related Protein 4 Inhibits Nonsmall Cell Lung Cancer Cell Proliferation While Promotes Apoptosis Through Sponging microRNA-21-5p. , 2020, Cancer biotherapy & radiopharmaceuticals.

[23]  Lauren M. Saunders,et al.  A-kinase-anchoring protein 1 (dAKAP1)-based signaling complexes coordinate local protein synthesis at the mitochondrial surface , 2020, The Journal of Biological Chemistry.

[24]  Fei Li,et al.  CircLARP4 Suppresses Cell Proliferation, Invasion and Glycolysis and Promotes Apoptosis in Non-Small Cell Lung Cancer by Targeting miR-135b , 2020, OncoTargets and therapy.

[25]  J. Deragon Distribution, organization an evolutionary history of La and LARPs in eukaryotes , 2020, RNA biology.

[26]  Xueqing Jiang,et al.  Circular RNA La‐related RNA‐binding protein 4 correlates with reduced tumor stage, as well as better prognosis, and promotes chemosensitivity to doxorubicin in breast cancer , 2020, Journal of clinical laboratory analysis.

[27]  James Y. Dai,et al.  DNA methylation and cis-regulation of gene expression by prostate cancer risk SNPs , 2020, PLoS genetics.

[28]  Lucas Lochovsky,et al.  Passenger Mutations in More Than 2,500 Cancer Genomes: Overall Molecular Functional Impact and Consequences , 2020, Cell.

[29]  Qi Shao,et al.  Circular RNA_LARP4 Sponges miR-1323 and Hampers Progression of Esophageal Squamous Cell Carcinoma Through Modulating PTEN/PI3K/AKT Pathway , 2020, Digestive Diseases and Sciences.

[30]  Yvonne Tay,et al.  The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium , 2019, Cells.

[31]  S. Janga,et al.  Human protein-RNA interaction network is highly stable across mammals , 2019, BMC Genomics.

[32]  Karen A. Lewis,et al.  The La-related proteins: structures and interactions of a versatile superfamily of RNA-binding proteins , 2019, RNA biology.

[33]  J. Ule,et al.  Subcellular mRNA Localization Regulates Ribosome Biogenesis in Migrating Cells , 2019, bioRxiv.

[34]  Y. Jiao,et al.  Expression of La Ribonucleoprotein Domain Family Member 4B (LARP4B) in Liver Cancer and Their Clinical and Prognostic Significance , 2019, Disease markers.

[35]  W. Wang,et al.  Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA‐424 in osteosarcoma , 2019, Journal of clinical laboratory analysis.

[36]  K. Hu,et al.  EuRBPDB: a comprehensive resource for annotation, functional and oncological investigation of eukaryotic RNA binding proteins (RBPs) , 2019, bioRxiv.

[37]  Xinbin Chen,et al.  Cancer The 'RBP'eutics - RNA-Binding Proteins as Therapeutic Targets for Cancer. , 2019, Pharmacology & therapeutics.

[38]  W. Yin,et al.  MicroRNA-106b functions as an oncogene and regulates tumor viability and metastasis by targeting LARP4B in prostate cancer , 2019, Molecular medicine reports.

[39]  T. Bui,et al.  LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA , 2019, Nucleic acids research.

[40]  Liyong Pu,et al.  circLARP4 induces cellular senescence through regulating miR‐761/RUNX3/p53/p21 signaling in hepatocellular carcinoma , 2019, Cancer science.

[41]  Y. Gao,et al.  Circular RNA_LARP4 is lower expressed and serves as a potential biomarker of ovarian cancer prognosis. , 2018, European review for medical and pharmacological sciences.

[42]  Jian-Hua Fu,et al.  miR-424 coordinates multilayered regulation of cell cycle progression to promote esophageal squamous cell carcinoma cell proliferation , 2018, EBioMedicine.

[43]  I. Cristea,et al.  Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription , 2018, bioRxiv.

[44]  Matthias W. Hentze,et al.  A brave new world of RNA-binding proteins , 2018, Nature Reviews Molecular Cell Biology.

[45]  Hui Liu,et al.  Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression , 2017, Molecular Cancer.

[46]  M. Conte,et al.  The La and related RNA‐binding proteins (LARPs): structures, functions, and evolving perspectives , 2017, Wiley interdisciplinary reviews. RNA.

[47]  Raquel Almeida,et al.  RNA-Binding Proteins in Cancer: Old Players and New Actors. , 2017, Trends in cancer.

[48]  C. Yau,et al.  A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay , 2017, Nature Communications.

[49]  U. Fischer,et al.  Loss of LARP4B , an early event in the tumorigenesis of brain cancer? , 2016 .

[50]  A. Ridley,et al.  The RNA‐binding protein LARP4 regulates cancer cell migration and invasion , 2016, Cytoskeleton.

[51]  S. Miyano,et al.  Identification of RNA-Binding Protein LARP4B as a Tumor Suppressor in Glioma. , 2016, Cancer research.

[52]  Jeroen Krijgsveld,et al.  The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs , 2015, Nature Communications.

[53]  S. Blagden,et al.  The La-Related Proteins, a Family with Connections to Cancer , 2015, Biomolecules.

[54]  M. Landthaler,et al.  LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation , 2015, RNA.

[55]  Jingliao Zhang,et al.  La-related protein 4B maintains murine MLL-AF9 leukemia stem cell self-renewal by regulating cell cycle progression. , 2015, Experimental hematology.

[56]  Michael B. Mann,et al.  Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression , 2015, Nature Genetics.

[57]  K. Pienta,et al.  Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells , 2014, Oncotarget.

[58]  S. Gerstberger,et al.  A census of human RNA-binding proteins , 2014, Nature Reviews Genetics.

[59]  R. Gillies,et al.  Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane , 2014, Cancer & metabolism.

[60]  S. Mi,et al.  Identification of functional cooperative mutations of SETD2 in human acute leukemia , 2014, Nature Genetics.

[61]  S. Janga,et al.  Dissecting the expression landscape of RNA-binding proteins in human cancers , 2014, Genome Biology.

[62]  Johann de Jong,et al.  Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model , 2013, Nature Genetics.

[63]  R. Hill,et al.  Targeting nucleocytoplasmic transport in cancer therapy , 2013, Oncotarget.

[64]  Bernat Gel,et al.  Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and genetic pathways driving tumorigenesis , 2013, Nature Genetics.

[65]  Bernd Fischer,et al.  RNA-binding proteins in Mendelian disease. , 2013, Trends in genetics : TIG.

[66]  Masao Nagasaki,et al.  Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells , 2012, Proceedings of the National Academy of Sciences.

[67]  G. Kristiansen,et al.  The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma , 2012, Nature.

[68]  S. Scherer,et al.  Clonal Selection Drives Genetic Divergence of Metastatic Medulloblastoma , 2012, Nature.

[69]  A. Rust,et al.  Insertional mutagenesis identifies multiple networks of co-operating genes driving intestinal tumorigenesis , 2011, Nature Genetics.

[70]  Stefan Wiemann,et al.  Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration , 2011, BMC Biology.

[71]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[72]  G. Kozlov,et al.  La-Related Protein 4 Binds Poly(A), Interacts with the Poly(A)-Binding Protein MLLE Domain via a Variant PAM2w Motif, and Can Promote mRNA Stability , 2010, Molecular and Cellular Biology.

[73]  A. Sickmann,et al.  A stimulatory role for the La-related protein 4B in translation. , 2010, RNA.

[74]  J. Deragon,et al.  A comprehensive analysis of the La-motif protein superfamily. , 2009, RNA.

[75]  Kai-Wei Chang,et al.  RNA-binding proteins in human genetic disease. , 2008, Trends in genetics : TIG.

[76]  D. Benjamin,et al.  mRNA stability and cancer: an emerging link? , 2007, Expert opinion on biological therapy.

[77]  Eugene V Koonin,et al.  Comparative genomics and evolution of proteins involved in RNA metabolism. , 2002, Nucleic acids research.

[78]  N. Yaegashi,et al.  La-Related Protein 4 as a Suppressor for Motility of Ovarian Cancer Cells. , 2019, The Tohoku journal of experimental medicine.

[79]  Thomas Tuschl,et al.  Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease. , 2014, Advances in experimental medicine and biology.