Protein engineering techniques for antibody humanization.
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[1] R. Poljak,et al. Three-dimensional structure of immunoglobulins. , 1979, Annual review of biochemistry.
[2] M. L. Connolly. Analytical molecular surface calculation , 1983 .
[3] A. Lesk,et al. Canonical structures for the hypervariable regions of immunoglobulins. , 1987, Journal of molecular biology.
[4] M. Lascombe,et al. Three-dimensional structure of antibodies. , 1988, Annual review of immunology.
[5] M Levitt,et al. A humanized antibody that binds to the interleukin 2 receptor. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[6] G. Winter,et al. Phage antibodies: filamentous phage displaying antibody variable domains , 1990, Nature.
[7] S. Spencer,et al. Pharmacokinetics, immune response, and biodistribution of iodine-131-labeled chimeric mouse/human IgG1,k 17-1A monoclonal antibody. , 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[8] E. Padlan,et al. A possible procedure for reducing the immunogenicity of antibody variable domains while preserving their ligand-binding properties. , 1991, Molecular immunology.
[9] Y. Masuho,et al. Phase I Study on Human Monoclonal Antibody Against Cytomegalovirus: Pharmacokinetics and Immunogenicity , 1991, Journal of immunotherapy : official journal of the Society for Biological Therapy.
[10] E. Kabat,et al. Sequences of proteins of immunological interest , 1991 .
[11] D R Burton,et al. Antibody redesign by chain shuffling from random combinatorial immunoglobulin libraries. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[12] K. Sandvig,et al. Internalization and action of an immunotoxin containing mistletoe lectin A-chain. , 1991, Cancer research.
[13] Geraldine Taylor,et al. Reshaping a Human Monoclonal Antibody to Inhibit Human Respiratory Syncytial Virus Infection in Vivo , 1991, Bio/Technology.
[14] J. Schlom,et al. Pharmacokinetics and immune response of 131I-chimeric mouse/human B72.3 (human gamma 4) monoclonal antibody in humans. , 1991, Cancer research.
[15] E. Vitetta,et al. Immunotoxins containing ricin or its A chain. , 1991, Seminars in cell biology.
[16] Andrew D. Griffiths,et al. By–Passing Immunization: Building High Affinity Human Antibodies by Chain Shuffling , 1992, Bio/Technology.
[17] A. Brill,et al. Intratumoral and whole-body distributions of C110 anti-carcinoembryonic antigen radioimmunotoxin after intraperitoneal and intravenous injection: a quantitative autoradiographic study. , 1992, Cancer research.
[18] S. Carroll,et al. Activity of recombinant mitogillin and mitogillin immunoconjugates. , 1992, The Journal of biological chemistry.
[19] Mu‐Hsien Yu,et al. Doxorubicin: monoclonal antibody conjugate for therapy of human cervical carcinoma , 1992, International journal of cancer.
[20] L. Presta,et al. Humanization of an anti-p185HER2 antibody for human cancer therapy. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[21] J. Schlom,et al. Phase I trial of iodine-131-chimeric B72.3 (human IgG4) in metastatic colorectal cancer. , 1992, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[22] T. Yokota,et al. Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms. , 1992, Cancer research.
[23] I. Pastan,et al. Recombinant toxins as novel therapeutic agents. , 1992, Annual review of biochemistry.
[24] C. Barbas,et al. Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[25] G. Winter,et al. Building Antibodies from their Genes , 1992, Immunological reviews.
[26] L. Presta,et al. X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling. , 1993, Journal of molecular biology.
[27] P Davies,et al. Optimal humanization of 1B4, an anti-CD18 murine monoclonal antibody, is achieved by correct choice of human V-region framework sequences. , 1993, Journal of immunology.
[28] J. Bye,et al. Human anti‐self antibodies with high specificity from phage display libraries. , 1993, The EMBO journal.
[29] L. Presta,et al. Humanization of an antibody directed against IgE. , 1993, Journal of immunology.
[30] Kevin Stuart Johnson,et al. Human antibody engineering , 1993 .
[31] J. Saunders,et al. Construction of a reshaped HMFG1 antibody and comparison of its fine specificity with that of the parent mouse antibody. , 1993, Immunology.
[32] J. Saldanha,et al. Humanization of a mouse anti-human IgE antibody: a potential therapeutic for IgE-mediated allergies. , 1993, Protein engineering.
[33] M. Lockyer,et al. A humanized CD18 antibody can block function without cell destruction. , 1993, Journal of Immunology.
[34] G. Winter,et al. Engineering bispecific antibodies. , 1993, Current opinion in biotechnology.
[35] J. Saldanha,et al. Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth. , 1993, Cancer Research.
[36] T. Waldmann,et al. Humanized Mik beta 1, a humanized antibody to the IL-2 receptor beta-chain that acts synergistically with humanized anti-TAC. , 1993, Journal of immunology.
[37] C. Barbas,et al. Selection of human anti-hapten antibodies from semisynthetic libraries. , 1993, Gene.
[38] H. P. Fell,et al. Genetic construction, expression, and characterization of a single chain anti-carcinoma antibody fused to beta-lactamase. , 1993, Cancer research.
[39] M. Hurle,et al. A role for destabilizing amino acid replacements in light-chain amyloidosis. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[40] A R Rees,et al. Comparison of surface accessible residues in human and murine immunoglobulin Fv domains. Implication for humanization of murine antibodies. , 1994, Journal of molecular biology.
[41] T. Waldmann. Lymphokine receptors: a target for immunotherapy of lymphomas. , 1994, Annals of oncology : official journal of the European Society for Medical Oncology.
[42] A R Rees,et al. Humanization of murine monoclonal antibodies through variable domain resurfacing. , 1994, Proceedings of the National Academy of Sciences of the United States of America.