INTERLABORATORY COMPARISON OF DIFFERENT SURVIVAL AND RELATIVE BIOLOGICAL EFFECTIVENESS* ALPHA-PARTICLE AND RADON SOURCES: CELL

Alpha radiation-induced cell killing was determined in four different laboratories in order to: 1) measure interlaboratory variability and 2) compare the effects of radon and radon daughter exposures with the effects of 238Pu (an often-used model for radon exposure). The results suggest that differences in handling from laboratory to laboratory can affect both low and high linear energy transfer responses and should be considered when comparing results from different laboratories. Health Phys. 62(5):458-461; 1992

[1]  P. Schonken,et al.  Health effects of exposure to low levels of ionizing radiation , 1991 .

[2]  J. Schwartz,et al.  The effects of radon daughter alpha-particle irradiation in K1 and xrs-5 CHO cell lines. , 1991, Mutation research.

[3]  R. Weichselbaum,et al.  Radiation-induced DNA double-strand break frequencies in human squamous cell carcinoma cell lines of different radiation sensitivities. , 1991, International journal of radiation biology.

[4]  R. Snyder,et al.  Comparison of radon‐daughter‐induced effects in repair‐proficient and repair‐deficient cho cell lines , 1990, Environmental and molecular mutagenesis.

[5]  D. J. Chen,et al.  The genotoxicity of alpha particles in human embryonic skin fibroblasts. , 1984, Radiation research.

[6]  G. Iliakis The mutagenicity of alpha particles in Ehrlich ascites tumor cells. , 1984, Radiation research.

[7]  D. Goodhead,et al.  The mutagenicity of alpha particles from plutonium-238. , 1982, Radiation research.

[8]  R. Painter,et al.  Evidence for repair of premutational damage from split X-ray doses. , 1980, Radiation Research.

[9]  W. Dewey,et al.  X-ray induction of 8-azaguanine-resistant mutants in synchronous Chinese hamster ovary cells. , 1980, Radiation research.

[10]  B. Barnhart,et al.  Mutagenicity and cytotoxicity of 4.4-MeV alpha particles emitted by plutonium-238. , 1979, Radiation research.

[11]  M. Ritter,et al.  High-LET radiations induce a large proportion of non-rejoining DNA breaks , 1977, Nature.

[12]  J. Jett,et al.  Age response for line CHO Chinese hamster cells exposed to x-irradiation and alpha particles from plutonium. , 1975, Radiation research.