[Prevalence of genital HPV infection among women screened for cervical cancer].

OBJECTIVE To assess the prevalence of high-risk genital human papillomavirus (HPV) infection by age group and risk factors associated. METHODS Cross-sectional study in a sample of 2,300 women (15-65 years old) who self-referred to cervical cancer screening in Sao Paulo and Campinas, Southeastern Brazil, between February 2002 and March 2003. An epidemiological questionnaire was applied and cervical specimens were obtained for cytology and hybrid capture II test (HCII) for HPV detection. Statistical analysis included Pearson Chi-square and unconditional multiple logistic regression model (forward likelihood ratio). RESULTS High-risk genital HPV infection prevalence in this sample was 17.8% and age distribution was as follows: 27.1% (<25 years), 21.3% (25-34 years), 12.1% (35-44 years), 12.0% (45-54 years) and 13.9% (55-65 years). Subjects with the highest number of lifetime sexual partners had the highest rates of genital HPV infection. To be living with a partner, aged 35 to 44 years, and former smokers were protective factors. High-risk genital HPV infection was 14.3% in normal cytology, 77.8% in high grade squamous intraepithelial lesions and in the two cases (100%) of cervical cancer. CONCLUSIONS High-risk HPV prevalence was high in the sample studied. The highest prevalence of HPV infection was seen in women under 25 years old and then a new increase was seen over the age of 55 and the highest rates were found among those with many sexual partners during their lifetime.

[1]  N. Muñoz,et al.  Epidemiology of HPV infection among Mexican women with normal cervical cytology , 2001, International journal of cancer.

[2]  J. Feldman,et al.  Declining Prevalence of Cervicovaginal Human Papillomavirus Infection With Age Is Independent of Other Risk Factors , 1996, Sexually transmitted diseases.

[3]  J. Aldrighi,et al.  [Serological detection of anti HPV 16/18 and its association with pap smear in adolescents and young women]. , 2006, Revista da Associacao Medica Brasileira.

[4]  José Mendes Aldrighi,et al.  ANICOLAOU EM ADOLESCENTES E MULHERES JOVENS , 2006 .

[5]  S. Franceschi,et al.  Population-based prevalence and age distribution of human papillomavirus among women in Santiago, Chile. , 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[6]  S. Tatti,et al.  Comparing PAP smear cytology, aided visual inspection, screening colposcopy, cervicography and HPV testing as optional screening tools in Latin America. Study design and baseline data of the LAMS study. , 2005, Anticancer research.

[7]  J. Eluf-Neto,et al.  Cervical cancer in Latin America. , 2001, Seminars in oncology.

[8]  David W. Hosmer,et al.  Applied Logistic Regression , 1991 .

[9]  S. Wacholder,et al.  Epidemiologic profile of type-specific human papillomavirus infection and cervical neoplasia in Guanacaste, Costa Rica. , 2005, The Journal of infectious diseases.

[10]  N. Muñoz,et al.  Prevalence of Human Papillomavirus Infection Among Women in Concordia, Argentina:: A Population-Based Study , 2003, Sexually transmitted diseases.

[11]  A. Giuliano,et al.  Human papillomavirus infection at the United States-Mexico border: implications for cervical cancer prevention and control. , 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[12]  C J L M Meijer,et al.  The causal relation between human papillomavirus and cervical cancer. , 2002, Journal of clinical pathology.

[13]  S. Wacholder,et al.  A prospective study of age trends in cervical human papillomavirus acquisition and persistence in Guanacaste, Costa Rica. , 2005, The Journal of infectious diseases.

[14]  Human Papillomavirus Infection at the United States-Mexico Border , 2001 .

[15]  S. Franceschi,et al.  Prevalence of papillomavirus infection in women in Ibadan, Nigeria: a population-based study , 2004, British Journal of Cancer.

[16]  A. Giuliano,et al.  Human papillomavirus prevalence at the USA–Mexico border among women 40 years of age and older , 2005, International journal of STD & AIDS.

[17]  Helen Trottier,et al.  The epidemiology of genital human papillomavirus infection. , 2006, Vaccine.

[18]  A. Lörincz.  Screening for cervical cancer: new alternatives and research. , 2003, Salud publica de Mexico.

[19]  M. Plummer,et al.  Population-Based Study of Human Papillomavirus Infection and Cervical Neoplasia in Rural Costa Rica , 2000 .

[20]  Mark Sherman,et al.  The 2001 Bethesda System: terminology for reporting results of cervical cytology. , 2002, JAMA.

[21]  S. Kjaer,et al.  Human Papillomavirus Infection in Danish Female Sex Workers: Decreasing Prevalence With Age Despite Continuously High Sexual Activity , 2000, Sexually transmitted diseases.

[22]  David R. Scott,et al.  Determinants of Genital Human Papillomavirus Infection in Low‐Risk Women in Portland, Oregon , 1993, Sexually transmitted diseases.

[23]  T. Rohan,et al.  Epidemiology of acquisition and clearance of cervical human papillomavirus infection in women from a high-risk area for cervical cancer. , 1999, The Journal of infectious diseases.

[24]  I. Catalá,et al.  Cervical Human Papillomavirus Infection in the Female Population in Barcelona, Spain , 2003, Sexually transmitted diseases.

[25]  J. Peto,et al.  Human papillomavirus is a necessary cause of invasive cervical cancer worldwide , 1999, The Journal of pathology.

[26]  S. Franceschi,et al.  Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: a pooled analysis , 2005, The Lancet.

[27]  J. Baseman,et al.  The epidemiology of human papillomavirus infections. , 2005, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.