Association between thiopurine medication exposure and Alzheimer's disease among a cohort of patients with inflammatory bowel disease

[1]  M. Buffelli,et al.  Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease , 2018, Acta neuropathologica communications.

[2]  Fan Hu,et al.  Distinctive roles of Rac1 and Rab29 in LRRK2 mediated membrane trafficking and neurite outgrowth , 2018, Journal of biomedical research.

[3]  F. LaFerla,et al.  Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony , 2017, Trends in Neurosciences.

[4]  C. Mulder,et al.  Rac1 as a Potential Pharmacodynamic Biomarker for Thiopurine Therapy in Inflammatory Bowel Disease , 2016, Therapeutic drug monitoring.

[5]  D. Nicholson,et al.  Evidence for Alzheimer’s disease-linked synapse loss and compensation in mouse and human hippocampal CA1 pyramidal neurons , 2015, Brain Structure and Function.

[6]  V. de Waard,et al.  6-Mercaptopurine Reduces Macrophage Activation and Gut Epithelium Proliferation Through Inhibition of GTPase Rac1 , 2014, Inflammatory bowel diseases.

[7]  V. de Waard,et al.  Inhibition of GTPase Rac1 in Endothelium by 6-Mercaptopurine Results in Immunosuppression in Nonimmune Cells: New Target for an Old Drug , 2014, The Journal of Immunology.

[8]  J. Zugaza,et al.  1–42 β-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death , 2013, Translational Psychiatry.

[9]  B. Hyman,et al.  Neuropathological alterations in Alzheimer disease. , 2011, Cold Spring Harbor perspectives in medicine.

[10]  Odelia Y. N. Bongmba,et al.  Modulation of dendritic spines and synaptic function by Rac1: A possible link to Fragile X syndrome pathology , 2011, Brain Research.

[11]  S. Lewin,et al.  Pharmacy adherence measures to assess adherence to antiretroviral therapy: review of the literature and implications for treatment monitoring. , 2011, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[12]  T. Kihara,et al.  Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene , 2009, Journal of neuroscience research.

[13]  M. Moskowitz,et al.  Rac1 Is a Critical Mediator of Endothelium-Derived Neurotrophic Activity , 2009, Science Signaling.

[14]  S. Hadano,et al.  The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis* , 2007, Journal of Biological Chemistry.

[15]  F. Schmitt,et al.  Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment , 2007, Neurology.

[16]  L. Mucke,et al.  A network dysfunction perspective on neurodegenerative diseases , 2006, Nature.

[17]  M. Neurath,et al.  Azathioprine Suppresses Ezrin-Radixin-Moesin-Dependent T Cell-APC Conjugation through Inhibition of Vav Guanosine Exchange Activity on Rac Proteins , 2006, The Journal of Immunology.

[18]  R. Maccioni,et al.  Modulation of the JNK and p38 pathways by cdk5 protein kinase in a transgenic mouse model of Alzheimer's disease , 2003, Neuroreport.

[19]  D. Bennett,et al.  Subicular dendritic arborization in Alzheimer's disease correlates with neurofibrillary tangle density. , 2003, The American journal of pathology.

[20]  B. Horazdovsky,et al.  Biochemical characterization of Alsin, a Rab5 and Rac1 guanine nucleotide exchange factor. , 2005, Methods in enzymology.