Hospital-acquired infections.

Health-acquired infection (HAI) is defined as a localized or systemic condition resulting from an adverse reaction to the presence of infectious agents or its toxins. This article focuses on HAIs that are well studied, common, and costly (direct, indirect, and intangible). The HAIs reviewed are catheter-related bloodstream infection, ventilator-associated pneumonia, surgical site infection, and catheter-associated urinary tract infection. This article excludes discussion of Clostridium difficile infections and vancomycin-resistant Enterococcus.

[1]  M. Wilcox,et al.  The use of a rapid in situ test in the detection of central venous catheter-related bloodstream infection: a prospective study. , 2003, JPEN. Journal of parenteral and enteral nutrition.

[2]  C. Clec’h,et al.  Does Catheter-Associated Urinary Tract Infection Increase Mortality in Critically Ill Patients? , 2007, Infection Control & Hospital Epidemiology.

[3]  Jordi Rello,et al.  Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. , 2002, Chest.

[4]  Tracie Wilcox Catheter-related bloodstream infections. , 2009, Seminars in interventional radiology.

[5]  B. Reeves,et al.  Surgical wound infection as a performance indicator: agreement of common definitions of wound infection in 4773 patients , 2004, BMJ : British Medical Journal.

[6]  R. Gaynes,et al.  Nosocomial Infections in Combined Medical-Surgical Intensive Care Units in the United States , 2000, Infection Control & Hospital Epidemiology.

[7]  Peter J Pronovost,et al.  Eliminating catheter-related bloodstream infections in the intensive care unit* , 2004, Critical care medicine.

[8]  J. Fine,et al.  Meta-Analysis: Methods for Diagnosing Intravascular DeviceRelated Bloodstream Infection , 2005, Annals of Internal Medicine.

[9]  J. Vincent,et al.  The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee. , 1995, JAMA.

[10]  J. Tarrand,et al.  Differential Time to Positivity: A Useful Method for Diagnosing Catheter-Related Bloodstream Infections , 2004, Annals of Internal Medicine.

[11]  Dan M. Kluger,et al.  The risk of bloodstream infection in adults with different intravascular devices: a systematic review of 200 published prospective studies. , 2006, Mayo Clinic proceedings.

[12]  K. Lobdell,et al.  Quality improvement program decreases mortality after cardiac surgery. , 2008, The Journal of thoracic and cardiovascular surgery.

[13]  K. Lobdell,et al.  Continuous quality improvement program and major morbidity after cardiac surgery. , 2008, The American journal of cardiology.

[14]  L. Neumayer,et al.  Multivariable predictors of postoperative surgical site infection after general and vascular surgery: results from the patient safety in surgery study. , 2007, Journal of the American College of Surgeons.

[15]  Sanjay Saint,et al.  Catheter-Associated Urinary Tract Infection and the Medicare Rule Changes , 2009, Annals of Internal Medicine.

[16]  S. Saint,et al.  Preventing hospital-acquired urinary tract infection in the United States: a national study. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[17]  D. Maki,et al.  The promise of novel technology for the prevention of intravascular device-related bloodstream infection. I. Pathogenesis and short-term devices. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[18]  Leonard Mermel,et al.  Prevention of Intravascular CatheterRelated Infections , 1994, Annals of Internal Medicine.

[19]  D. Cardo,et al.  Estimating Health Care-Associated Infections and Deaths in U.S. Hospitals, 2002 , 2007, Public health reports.

[20]  R. Gaynes,et al.  CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. , 1992, Infection control and hospital epidemiology.

[21]  Jeanne E. Zack,et al.  Effect of an education program on decreasing catheter-related bloodstream infections in the surgical intensive care unit , 2002, Critical care medicine.

[22]  R. Gaynes,et al.  Detection of Postoperative Surgical-Site Infections: Comparison of Health Plan–Based Surveillance With Hospital-Based Programs , 2003, Infection Control & Hospital Epidemiology.

[23]  W. Jarvis Infection Control and Hospital Epidemiology: Transitioning Through Adolescence! , 2006, Infection Control & Hospital Epidemiology.

[24]  P. Lipsett,et al.  Risk factors and clinical impact of central line infections in the surgical intensive care unit. , 1998, Archives of surgery.

[25]  P. Tambyah,et al.  Engineering out the risk for infection with urinary catheters. , 2001, Emerging infectious diseases.

[26]  Gordon Guyatt,et al.  Incidence of and Risk Factors for Ventilator-Associated Pneumonia in Critically Ill Patients , 1998, Annals of Internal Medicine.

[27]  E. Bouza,et al.  Nasal carriage of S. aureus increases the risk of surgical site infection after major heart surgery. , 2008, The Journal of hospital infection.

[28]  L. Kozak,et al.  Ambulatory and inpatient procedures in the United States, 1996. , 1998, Vital and health statistics. Series 13, Data from the National Health Survey.

[29]  I. Raad,et al.  Blood Products: A Significant Risk Factor for Long-Term Catheter-Related Bloodstream Infections in Cancer Patients , 2001, Infection Control & Hospital Epidemiology.

[30]  O. Wenker,et al.  A comparison of two antimicrobial-impregnated central venous catheters. Catheter Study Group. , 1999, The New England journal of medicine.

[31]  M. Hawn,et al.  Association of timely administration of prophylactic antibiotics for major surgical procedures and surgical site infection. , 2008, Journal of the American College of Surgeons.

[32]  Helen Burstin,et al.  Strategies to Prevent Ventilator-Associated Pneumonia in Acute Care Hospitals , 2008, Infection Control & Hospital Epidemiology.

[33]  A. Charlett,et al.  Duration of operation as a risk factor for surgical site infection: comparison of English and US data. , 2006, The Journal of hospital infection.

[34]  D. Spelman,et al.  A New Surgical-Site Infection Risk Index Using Risk Factors Identified by Multivariate Analysis for Patients Undergoing Coronary Artery Bypass Graft Surgery , 2002, Infection Control & Hospital Epidemiology.

[35]  K. Lobdell Value creation in cardiac surgery using the Toyota Production System. , 2011, The Annals of thoracic surgery.

[36]  K. Lobdell,et al.  Quality Improvement Program Increases Early Tracheal Extubation Rate and Decreases Pulmonary Complications and Resource Utilization After Cardiac Surgery , 2009, Journal of cardiac surgery.

[37]  Johan Decruyenaere,et al.  Clinical and economic outcomes in critically ill patients with nosocomial catheter-related bloodstream infections. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[38]  D. Maki,et al.  Bacteriuria in the catheterized patient. What quantitative level of bacteriuria is relevant , 1984 .

[39]  P. Tambyah,et al.  A prospective study of pathogenesis of catheter-associated urinary tract infections. , 1999, Mayo Clinic proceedings.

[40]  E. Lusk,et al.  Psychosocial status in chronic illness. A comparative analysis of six diagnostic groups. , 1984, The New England journal of medicine.

[41]  M. Higgins,et al.  The attributable mortality and costs of primary nosocomial bloodstream infections in the intensive care unit. , 1999, American journal of respiratory and critical care medicine.

[42]  F. Grover,et al.  The Department of Veterans Affairs' NSQIP: the first national, validated, outcome-based, risk-adjusted, and peer-controlled program for the measurement and enhancement of the quality of surgical care. National VA Surgical Quality Improvement Program. , 1998, Annals of surgery.

[43]  D. Maki Nosocomial bacteremia. An epidemiologic overview. , 1981, The American journal of medicine.

[44]  F. Gottrup An overview of surgical site infections: aetiology, incidence and risk factors , 2005 .

[45]  T. Speroff,et al.  Using real time process measurements to reduce catheter related bloodstream infections in the intensive care unit , 2005, Quality and Safety in Health Care.

[46]  J. Edwards,et al.  National Healthcare Safety Network (NHSN) Report, data summary for 2006, issued June 2007. , 2007, American journal of infection control.

[47]  P. Pronovost,et al.  An intervention to decrease catheter-related bloodstream infections in the ICU. , 2006, The New England journal of medicine.

[48]  Jekel Jf,et al.  Utilizing national nosocomial infection surveillance system data to improve urinary tract infection rates in three intensive-care units. , 1998 .

[49]  Peter Pronovost,et al.  Interventions to decrease catheter-related bloodstream infections in the ICU: the Keystone Intensive Care Unit Project. , 2008, American journal of infection control.

[50]  G. Grunkemeier,et al.  Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures. , 1999, The Annals of thoracic surgery.

[51]  J Mollison,et al.  The measurement and monitoring of surgical adverse events. , 2001, Health technology assessment.

[52]  Margaret A Dudeck,et al.  CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. , 2008, American journal of infection control.

[53]  Marin H Kollef,et al.  The effect of an education program on the incidence of central venous catheter-associated bloodstream infection in a medical ICU. , 2004, Chest.

[54]  P. Meyer,et al.  Surgical site infections associated with methicillin-resistant Staphylococcus aureus: do postoperative factors play a role? , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[55]  R. Coello,et al.  Infection of the surgical site after arthroplasty of the hip. , 2005, The Journal of bone and joint surgery. British volume.

[56]  Sanjay Saint,et al.  Guidelines for the prevention of intravascular catheter-related infections. , 2002, American journal of infection control.

[57]  D. Fry,et al.  Use of antimicrobial prophylaxis for major surgery: baseline results from the National Surgical Infection Prevention Project. , 2005, Archives of surgery.

[58]  L. Brochard,et al.  Secular trends in nosocomial infections and mortality associated with noninvasive ventilation in patients with exacerbation of COPD and pulmonary edema. , 2003, JAMA.

[59]  Aneil K. Mishra,et al.  Multidisciplinary rounds: the work, not more work. , 2010, The Annals of thoracic surgery.

[60]  S. Fridkin,et al.  The Influence of the Composition of the Nursing Staff on Primary Bloodstream Infection Rates in a Surgical Intensive Care Unit , 2000, Infection Control & Hospital Epidemiology.

[61]  B. Trautner,et al.  Role of biofilm in catheter-associated urinary tract infection. , 2004, American journal of infection control.

[62]  Anita L. Tucker,et al.  Implementing New Practices: An Empirical Study of Organizational Learning in Hospital Intensive Care Units , 2007, Manag. Sci..

[63]  Marlene R. Miller,et al.  Increased Catheter-Related Bloodstream Infection Rates After the Introduction of a New Mechanical Valve Intravenous Access Port , 2006, Infection Control & Hospital Epidemiology.

[64]  Richard F. Averill,et al.  Estimating the Costs of Potentially Preventable Hospital Acquired Complications , 2009, Health care financing review.

[65]  Jean-Yves Fagon,et al.  Ventilator-associated pneumonia. , 2002 .

[66]  F. Biscione Reply to Chen et al , 2008, Infection Control & Hospital Epidemiology.

[67]  D. Cook,et al.  Risk factors for ICU-acquired pneumonia. , 1998, JAMA.

[68]  M. Kollef,et al.  Ventilator-associated pneumonia: insights from recent clinical trials. , 2005, Chest.

[69]  Peter J Pronovost,et al.  Sustaining reductions in catheter related bloodstream infections in Michigan intensive care units: observational study , 2010, BMJ : British Medical Journal.

[70]  K. Chapin,et al.  Epidemiology and Outcome of Nosocomial and Community-Onset Bloodstream Infection , 2003, Journal of Clinical Microbiology.

[71]  R. Platt,et al.  Automated methods for surveillance of surgical site infections. , 2001, Emerging infectious diseases.