A robust and fast method for arterial lumen diameter and intima-media thickness measurements

Lumen diameter, distension and intima-media thickness (IMT) in human arteries are important parameters in cardiovascular research. The signal reflected from the arterial wall strongly depends on the ultrasound scanner and settings. The signal also varies with age and health of the subject. A general method insensitive with respect to the subject and the scanner would be of great help. We have developed a novel and robust method for ARTerIal Characterization (ARTIC), suitable for real-time in vivo measurements of diameter, distension and IMT using B-Mode images. The aim of this study was to evaluate ARTIC on different subjects and scanners. ARTIC was evaluated in vivo in different groups of subjects using two scanners, HDI5000 (Philips Medical Systems, Bothell, WA, USA) and ULAOP (University of Florence, Italy). First, a comparison was made against a previous method validated on phantoms. Then measurements of young (healthy) and old (healthy and unhealthy) subjects were evaluated for both scanners. Finally, a comparison between scanners was made. The evaluation of different subjects shows a coefficient of variation (CV) ranging from 1.4-2.0% for diameter, 4.3-8.8% for distension and 3.66.6% for IMT.

[1]  H. Kanai,et al.  Real-time measurements of local myocardium motion and arterial wall thickening , 1999, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[2]  T. Jansson,et al.  New non-invasive method for intima-media thickness and intima-media compression measurements , 2005, IEEE Ultrasonics Symposium, 2005..

[3]  P Pignoli,et al.  Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. , 1986, Circulation.

[4]  Leonhard Reindl,et al.  Passive radio requestable SAW water content sensor , 1999, 1999 IEEE Ultrasonics Symposium. Proceedings. International Symposium (Cat. No.99CH37027).

[5]  A. Dallai,et al.  A reconfigurable and programmable FPGA-based system for nonstandard ultrasound methods , 2012, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[6]  H. Tuller,et al.  Defects and transport in langasite I: Acceptor-doped (La3Ga5SiO14) , 2006 .

[7]  Å. Ahlgren,et al.  An Automatic Method for Measurements of Arterial Intima-Media Thickness Using Ultrasonic B-Mode Data , 2012 .

[8]  P. Touboul,et al.  Clinical impact of intima media measurement. , 2002, European journal of ultrasound : official journal of the European Federation of Societies for Ultrasound in Medicine and Biology.

[9]  A. Dallai,et al.  ULA-OP: an advanced open platform for ultrasound research , 2009, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[10]  D. Ley,et al.  Arterial diameter change measurements in premature rabbit pups using B-Mode images , 2012, 2012 IEEE International Ultrasonics Symposium.

[11]  J. Blacher,et al.  Impact of aortic stiffness on survival in end-stage renal disease. , 1999, Circulation.

[12]  R S Reneman,et al.  Non-invasive measurement of mechanical properties of arteries in health and disease , 1999, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[13]  Badreddine Assouar,et al.  Iridium interdigital transducers for high-temperature surface acoustic wave applications , 2012, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

[14]  Holger Fritze.  High temperature piezoelectric materials: Defect chemistry and electro-mechanical properties , 2006 .

[15]  Å. Ahlgren,et al.  A method for arterial diameter change measurements using ultrasonic B-mode data. , 2010, Ultrasound in medicine & biology.

[16]  T. Moonlight,et al.  High temperature stability of langasite surface acoustic wave devices , 2008, 2008 IEEE Ultrasonics Symposium.

[17]  Lysle H. Peterson,et al.  Mechanical Properties of Arteries in Vivo , 1960 .

[18]  S Sasayama,et al.  Non-invasive assessment of the age related changes in stiffness of major branches of the human arteries. , 1987, Cardiovascular research.

[19]  P. Ducimetiere,et al.  Aortic Stiffness Is an Independent Predictor of All-Cause and Cardiovascular Mortality in Hypertensive Patients , 2001, Hypertension.

[20]  M. Schulz,et al.  Diffusion-related implications for langasite resonator operation , 2004, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[21]  R. Fachberger,et al.  Influence of packaging atmospheres on the durability of high-temperature SAW sensors , 2009, 2009 IEEE International Ultrasonics Symposium.