Cdc42 controls progenitor cell differentiation and -catenin turnover in skin

Max Planck Institute of Biochemistry, Heisenberg Group “Regulation of Cytoskeletal Organization,” Department of Molecular Medicine, 82152 Martinsried, Germany; Georg August University Göttingen, Department of Histology, 37075 Göttingen, Germany; Max Planck Institute of Biochemistry, Department of Molecular Medicine, 82152 Martinsried, Germany; University Hospital Schleswig-Holstein, Department of Dermatology, University of Lübeck, 23538 Lübeck, Germany; Cell German Cancer Research Center, Department of Cell Biology, 69120 Heidelberg, Germany

[1]  Klemens Rottner,et al.  Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells. , 2005, Molecular biology of the cell.

[2]  F. Watt,et al.  Stem Cell Depletion Through Epidermal Deletion of Rac1 , 2005, Science.

[3]  R. Paus,et al.  Molecular principles of hair follicle induction and morphogenesis , 2005, BioEssays : news and reviews in molecular, cellular and developmental biology.

[4]  F. Brembeck,et al.  Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. , 2004, Genes & development.

[5]  M. Vidal,et al.  A keratin K5Cre transgenic line appropriate for tissue‐specific or generalized cre‐mediated recombination , 2004, Genesis.

[6]  H. Pasolli,et al.  Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[7]  M. Peifer,et al.  Traffic control , 2003, The Journal of cell biology.

[8]  E. Fuchs,et al.  Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA , 2003, The Journal of cell biology.

[9]  U. Suter,et al.  E‐cadherin controls adherens junctions in the epidermis and the renewal of hair follicles , 2003, The EMBO journal.

[10]  R. DePinho,et al.  LKB1 (XEEK1) regulates Wnt signalling in vertebrate development , 2003, Nature Cell Biology.

[11]  E. Fuchs,et al.  Stem cells in the skin: waste not, Wnt not. , 2003, Genes & development.

[12]  B. Doble,et al.  GSK-3: tricks of the trade for a multi-tasking kinase , 2003, Journal of Cell Science.

[13]  N. Heisterkamp,et al.  p120 Catenin-Associated Fer and Fyn Tyrosine Kinases Regulate β-Catenin Tyr-142 Phosphorylation and β-Catenin-α-Catenin Interaction , 2003, Molecular and Cellular Biology.

[14]  Elaine Fuchs,et al.  Sticky Business Orchestrating Cellular Signals at Adherens Junctions , 2003, Cell.

[15]  A. Hall,et al.  Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity , 2003, Nature.

[16]  J. Jorcano,et al.  The Expression of Keratin K10 in the Basal Layer of the Epidermis Inhibits Cell Proliferation and Prevents Skin Tumorigenesis* , 2002, The Journal of Biological Chemistry.

[17]  Hans Clevers,et al.  Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors , 2002, Molecular and Cellular Biology.

[18]  A. Hall,et al.  Integrin-Mediated Activation of Cdc42 Controls Cell Polarity in Migrating Astrocytes through PKCζ , 2001, Cell.

[19]  E. Fuchs,et al.  Hyperproliferation and Defects in Epithelial Polarity upon Conditional Ablation of α-Catenin in Skin , 2001, Cell.

[20]  F. McCormick,et al.  Differential Regulation of Glycogen Synthase Kinase 3β by Insulin and Wnt Signaling* , 2000, The Journal of Biological Chemistry.

[21]  T. Pawson,et al.  A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity , 2000, Nature Cell Biology.

[22]  G. Joberty,et al.  The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 , 2000, Nature Cell Biology.

[23]  A. Hall,et al.  Rho GTPases and their effector proteins. , 2000, The Biochemical journal.

[24]  F. Alt,et al.  Cdc42 is required for PIP2-induced actin polymerization and early development but not for cell viability , 2000, Current Biology.

[25]  John G. Collard,et al.  Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition , 2000, The Journal of cell biology.

[26]  R. Burgeson,et al.  Wnt signaling maintains the hair-inducing activity of the dermal papilla. , 2000, Genes & development.

[27]  A. Ciechanover,et al.  Differential interaction of plakoglobin and β-catenin with the ubiquitin-proteasome system , 2000, Oncogene.

[28]  A. Gandarillas.  Epidermal differentiation, apoptosis, and senescence: common pathways? , 2000, Experimental Gerontology.

[29]  Albert B. Reynolds,et al.  Selective Uncoupling of P120ctn from E-Cadherin Disrupts Strong Adhesion , 2000, The Journal of cell biology.

[30]  Dianqing Wu,et al.  Suppression of Glycogen Synthase Kinase Activity Is Not Sufficient for Leukemia Enhancer Factor-1 Activation* , 1999, The Journal of Biological Chemistry.

[31]  R. Nusse,et al.  Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex. , 1999, Genes & development.

[32]  P. Fleckman,et al.  Long-term culture of murine epidermal keratinocytes. , 1999, The Journal of investigative dermatology.

[33]  Yih-Tai Chen,et al.  Coupling Assembly of the E-Cadherin/β-Catenin Complex to Efficient Endoplasmic Reticulum Exit and Basal-lateral Membrane Targeting of E-Cadherin in Polarized MDCK Cells , 1999, The Journal of cell biology.

[34]  F. Watt,et al.  Analysis of cultured keratinocytes from a transgenic mouse model of psoriasis: effects of suprabasal integrin expression on keratinocyte adhesion, proliferation and terminal differentiation , 1999, Experimental dermatology.

[35]  B. Geiger,et al.  Inhibition of β-catenin-mediated transactivation by cadherin derivatives , 1998 .

[36]  N. Nomura,et al.  Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion. , 1998, Science.

[37]  Benjamin Geiger,et al.  Differential Nuclear Translocation and Transactivation Potential of β-Catenin and Plakoglobin , 1998, The Journal of cell biology.

[38]  B. Sanson,et al.  Uncoupling cadherin-based adhesion from wingless signalling in Drosophila , 1996, Nature.

[39]  M. Peifer,et al.  Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis , 1996, The Journal of cell biology.

[40]  B. Gumbiner,et al.  Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus , 1996, The Journal of cell biology.

[41]  P. McCrea,et al.  Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos , 1994, Cell.

[42]  J. K. Mfopou,et al.  Expression of regulatory genes for pancreas development during murine embryonic stem cell differentiation. , 2005, The International journal of developmental biology.

[43]  E. Fuchs,et al.  A developmental conundrum: a stabilized form of (cid:2) -catenin lacking the transcriptional activation domain triggers features of hair cell fate in epidermal cells and epidermal cell fate in hair follicle cells , 2002 .

[44]  H. Schwarz,et al.  Desmosomal localization of β-catenin in the skin of plakoglobin null -mutant mice , 1998 .

[45]  M. Gschwendt,et al.  Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. , 1996, FEBS letters.

[46]  S. Orsulic,et al.  E-cadherin binding prevents β-catenin nuclear localization and β-catenin / LEF-1-mediated transactivation , 2022 .