Hepatic Insulin Signaling is Dispensable for Suppression of Glucose Output by Insulin in Vivo
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[1] L. Cantley,et al. Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome , 2014, Cell.
[2] Randy J. Seeley,et al. Cooperation between brain and islet in glucose homeostasis and diabetes , 2013, Nature.
[3] M. Birnbaum,et al. A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition. , 2013, Cell metabolism.
[4] D. Edgerton,et al. Interaction Between the Central and Peripheral Effects of Insulin in Controlling Hepatic Glucose Metabolism in the Conscious Dog , 2012, Diabetes.
[5] David P. Olson,et al. Central nervous system control of metabolism , 2012, Nature.
[6] Robert V Farese,et al. Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. , 2012, Cell metabolism.
[7] D. Edgerton,et al. Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production. , 2012, Cell metabolism.
[8] M. White,et al. The AKTion in non-canonical insulin signaling , 2012, Nature Medicine.
[9] C. Kahn,et al. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1 , 2012, Nature Medicine.
[10] K. Kaestner,et al. Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. , 2011, Cell metabolism.
[11] A. Mari,et al. Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs. , 2011, The Journal of clinical investigation.
[12] Derek W. Yecies,et al. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. , 2011, Cell metabolism.
[13] D. Accili,et al. Hormonal regulation of hepatic glucose production in health and disease. , 2011, Cell metabolism.
[14] K. Kaestner,et al. Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. , 2011, The Journal of clinical investigation.
[15] M. Birnbaum,et al. Insulin signaling to hepatic lipid metabolism in health and disease , 2011, Critical reviews in biochemistry and molecular biology.
[16] M. White,et al. Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction , 2011, Nature Medicine.
[17] R. Rizza. Pathogenesis of Fasting and Postprandial Hyperglycemia in Type 2 Diabetes: Implications for Therapy , 2010, Diabetes.
[18] Shijie Li,et al. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis , 2010, Proceedings of the National Academy of Sciences.
[19] K. Polonsky,et al. Insulin signaling in alpha cells modulates glucagon secretion in vivo. , 2009, Cell metabolism.
[20] R. DePinho,et al. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. , 2008, Cell metabolism.
[21] J. Yates,et al. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. , 2007, Nature.
[22] R. DePinho,et al. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. , 2007, Cell metabolism.
[23] F. Ashcroft,et al. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. , 2007, Cell metabolism.
[24] D. Leroith,et al. Mechanisms of Disease: metabolic effects of growth hormone and insulin-like growth factor 1 , 2007, Nature Clinical Practice Endocrinology &Metabolism.
[25] G. Shulman,et al. Targeting Foxo1 in Mice Using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action , 2006, Diabetes.
[26] S. Akira,et al. Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. , 2006, Cell metabolism.
[27] M. Montminy,et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism , 2005, Nature.
[28] D. Accili,et al. Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action. , 2005, The Journal of clinical investigation.
[29] J. Adamson,et al. Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis , 2003, Nature Genetics.
[30] Bruce M. Spiegelman,et al. Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction , 2003, Nature.
[31] C. Kahn,et al. Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production. , 2003, The Journal of clinical investigation.
[32] P. Cohen,et al. Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion , 2002, The EMBO journal.
[33] C. Kahn,et al. Insulin signalling and the regulation of glucose and lipid metabolism , 2001, Nature.
[34] R. Bergman,et al. Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin. , 2000, American journal of physiology. Endocrinology and metabolism.
[35] C. Kahn,et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. , 2000, Molecular cell.
[36] D. Accili,et al. Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway* , 1999, The Journal of Biological Chemistry.
[37] C. Kahn,et al. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. , 1998, Molecular cell.
[38] M. Vranic,et al. Fatty Acids Mediate the Acute Extrahepatic Effects of Insulin on Hepatic Glucose Production in Humans , 1997, Diabetes.
[39] R. Bergman,et al. Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. , 1996, The Journal of clinical investigation.
[40] R. Levine,et al. The Relation of Insulin to Liver Metabolism , 1956, Diabetes.
[41] Mustafa Saad,et al. Implications for Therapy , 2016 .
[42] M. Schwartz,et al. Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. , 2006, Cell metabolism.
[43] A. Pocai,et al. A brain-liver circuit regulates glucose homeostasis. , 2005, Cell metabolism.
[44] Jerry Donovan,et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. , 2003, Nature.
[45] M. Diamond,et al. Effects of small changes in glucagon on glucose production during a euglycemic, hyperinsulinemic clamp. , 1991, Metabolism: clinical and experimental.