α‐Synuclein sequesters arachidonic acid to modulate SNARE‐mediated exocytosis

[1]  R. Nicoll,et al.  Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis , 2010, Neuron.

[2]  N. Vitale,et al.  Phospholipase D in calcium-regulated exocytosis: lessons from chromaffin cells. , 2009, Biochimica et biophysica acta.

[3]  J. Meldolesi,et al.  {alpha}-synuclein and its A30P mutant affect actin cytoskeletal structure and dynamics. , 2009, Molecular biology of the cell.

[4]  M. Kreft,et al.  Sphingosine Facilitates SNARE Complex Assembly and Activates Synaptic Vesicle Exocytosis , 2009, Neuron.

[5]  M. Cookson.  α-Synuclein and neuronal cell death , 2009, Molecular Neurodegeneration.

[6]  D. Selkoe,et al.  α‐Synuclein and Polyunsaturated Fatty Acids Promote Clathrin‐Mediated Endocytosis and Synaptic Vesicle Recycling , 2009, Traffic.

[7]  T. Lang,et al.  Interplay between lipids and the proteinaceous membrane fusion machinery. , 2008, Progress in lipid research.

[8]  T. Melia.  Putting the clamps on membrane fusion: How complexin sets the stage for calcium‐mediated exocytosis , 2007, FEBS letters.

[9]  B. Davletov,et al.  Mechanism of arachidonic acid action on syntaxin–Munc18 , 2007, EMBO reports.

[10]  C. Montecucco,et al.  Glycogen synthase kinase 3 activation is essential for the snake phospholipase A2 neurotoxin‐induced secretion in chromaffin cells , 2007, The European journal of neuroscience.

[11]  M. Goedert,et al.  α-synuclein adopts an α-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation , 2006 .

[12]  Leonidas Stefanis,et al.  α-Synuclein Overexpression in PC12 and Chromaffin Cells Impairs Catecholamine Release by Interfering with a Late Step in Exocytosis , 2006, The Journal of Neuroscience.

[13]  F. Meunier,et al.  Arachidonic acid potentiates exocytosis and allows neuronal SNARE complex to interact with Munc18a , 2006, Journal of neurochemistry.

[14]  A. Linstedt.  Faculty Opinions recommendation of Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. , 2006 .

[15]  S. Lindquist,et al.  α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models , 2006, Science.

[16]  R. Nussbaum,et al.  Acyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolism. , 2006, Biochemistry.

[17]  Cesare Montecucco,et al.  Presynaptic enzymatic neurotoxins , 2006, Journal of neurochemistry.

[18]  G. Schiavo,et al.  Equivalent Effects of Snake PLA2 Neurotoxins and Lysophospholipid-Fatty Acid Mixtures , 2005, Science.

[19]  B. Davletov,et al.  Promiscuous interaction of SNAP-25 with all plasma membrane syntaxins in a neuroendocrine cell. , 2005, The Biochemical journal.

[20]  Thomas C. Südhof,et al.  α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration , 2005, Cell.

[21]  N. Hattori,et al.  A Combinatorial Code for the Interaction of α-Synuclein with Membranes* , 2005, Journal of Biological Chemistry.

[22]  N. Bazan.  Lipid signaling in neural plasticity, brain repair, and neuroprotection , 2005, Molecular Neurobiology.

[23]  B. Davletov,et al.  Arachidonic acid allows SNARE complex formation in the presence of Munc18. , 2005, Chemistry & biology.

[24]  H. Tanila,et al.  Role of α-Synuclein in Presynaptic Dopamine Recruitment , 2004, The Journal of Neuroscience.

[25]  Richard Paylor,et al.  Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking α-Synuclein , 2002, The Journal of Neuroscience.

[26]  Anatol C. Kreitzer,et al.  Retrograde signaling by endocannabinoids , 2002, Current Opinion in Neurobiology.

[27]  B. Davletov,et al.  Vesicular restriction of synaptobrevin suggests a role for calcium in membrane fusion , 2002, Nature.

[28]  R. Perrin,et al.  Exposure to Long Chain Polyunsaturated Fatty Acids Triggers Rapid Multimerization of Synucleins* , 2001, The Journal of Biological Chemistry.

[29]  C. Specht,et al.  Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice , 2001, BMC Neuroscience.

[30]  Rebecca A. Betensky,et al.  α-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[31]  Glenda M. Halliday,et al.  Clinical and pathological features of a parkinsonian syndrome in a family with an Ala53Thr α‐synuclein mutation , 2001 .

[32]  J. Trojanowski,et al.  Synucleins Are Developmentally Expressed, and α-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal Neurons , 2000, The Journal of Neuroscience.

[33]  Heidi Phillips,et al.  Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System , 2000, Neuron.

[34]  D. Clayton,et al.  Synucleins in synaptic plasticity and neurodegenerative disorders , 1999, Journal of neuroscience research.

[35]  R. Cunha,et al.  Facilitation by arachidonic acid of acetylcholine release from the rat hippocampus , 1999, Brain Research.

[36]  Mark K. Bennett,et al.  A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion , 1993, Cell.

[37]  D. Terrian,et al.  Presynaptic facilitation of glutamate release from isolated hippocampal mossy fiber nerve endings by arachidonic acid , 1990, Neurochemical Research.

[38]  M. Goedert,et al.  Alpha-synuclein adopts an alpha-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation. , 2006, Biochemistry.

[39]  T. Südhof,et al.  Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. , 2005, Cell.

[40]  N. Hattori,et al.  A combinatorial code for the interaction of alpha-synuclein with membranes. , 2005, The Journal of biological chemistry.

[41]  M. Wenk.  Inaugural Article: Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: Insights from vesicle recycling in nerve terminals , 2004 .

[42]  H. Tanila,et al.  Role of alpha-synuclein in presynaptic dopamine recruitment. , 2004, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[43]  D. Sulzer,et al.  Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. , 2000, Neuron.

[44]  M G Spillantini,et al.  Alpha-synuclein in Lewy bodies. , 1997, Nature.