“Soap‐Bubble” visualization and quantitative analysis of 3D coronary magnetic resonance angiograms

In order to compare coronary magnetic resonance angiography (MRA) data obtained with different scanning methodologies, adequate visualization and presentation of the coronary MRA data need to be ensured. Furthermore, an objective quantitative comparison between images acquired with different scanning methods is desirable. To address this need, a software tool (“Soap‐Bubble”) that facilitates visualization and quantitative comparison of 3D volume targeted coronary MRA data was developed. In the present implementation, the user interactively specifies a curved subvolume (enclosed in the 3D coronary MRA data set) that closely encompasses the coronary arterial segments. With a 3D Delaunay triangulation and a parallel projection, this enables the simultaneous display of multiple coronary segments in one 2D representation. For objective quantitative analysis, frequently explored quantitative parameters such as signal‐to‐noise ratio (SNR); contrast‐to‐noise ratio (CNR); and vessel length, sharpness, and diameter can be assessed. The present tool supports visualization and objective, quantitative comparisons of coronary MRA data obtained with different scanning methods. The first results obtained in healthy adults and in patients with coronary artery disease are presented. Magn Reson Med 48:658–666, 2002. © 2002 Wiley‐Liss, Inc.

[1]  Anders M. Dale,et al.  Cortical Surface-Based Analysis I. Segmentation and Surface Reconstruction , 1999, NeuroImage.

[2]  M. McConnell,et al.  Prospective adaptive navigator correction for breath‐hold MR coronary angiography , 1997, Magnetic resonance in medicine.

[3]  René M. Botnar,et al.  Three‐dimensional high‐resolution fast spin‐echo coronary magnetic resonance angiography , 2001, Magnetic resonance in medicine.

[4]  M Weiger,et al.  Motion‐adapted gating based on k‐space weighting for reduction of respiratory motion artifacts , 1997, Magnetic resonance in medicine.

[5]  René M. Botnar,et al.  Free‐breathing 3D coronary MRA: The impact of “Isotropic” image resolution , 2000, Journal of magnetic resonance imaging : JMRI.

[6]  René M. Botnar,et al.  Coronary magnetic resonance angiography for the detection of coronary stenoses. , 2001, The New England journal of medicine.

[7]  W. Manning,et al.  Simultaneous acquisition of spatial harmonics (SMASH): Fast imaging with radiofrequency coil arrays , 1997, Magnetic resonance in medicine.

[8]  Bob S. Hu,et al.  Fast Spiral Coronary Artery Imaging , 1992, Magnetic resonance in medicine.

[9]  René M. Botnar,et al.  Free-breathing black-blood coronary MR angiography: initial results. , 2001, Radiology.

[10]  C J Hardy,et al.  Coronary angiography by real‐time MRI with adaptive averaging , 2000, Magnetic resonance in medicine.

[11]  Y Wang,et al.  Coronary MR angiography: selection of acquisition window of minimal cardiac motion with electrocardiography-triggered navigator cardiac motion prescanning--initial results. , 2001, Radiology.

[12]  O. Simonetti,et al.  Contrast‐enhanced coronary MR angiography: Relationship between coronary artery delineation and blood T1 , 2001, Journal of magnetic resonance imaging : JMRI.

[13]  R. Dolan,et al.  Three‐dimensional MRI of coronary arteries using an intravascular contrast agent , 1998, Magnetic resonance in medicine.

[14]  René M. Botnar,et al.  Impact of bulk cardiac motion on right coronary MR angiography and vessel wall imaging , 2001, Journal of magnetic resonance imaging : JMRI.

[15]  René M. Botnar,et al.  Contrast agent‐enhanced, free‐breathing, three‐dimensional coronary magnetic resonance angiography , 1999, Journal of magnetic resonance imaging : JMRI.

[16]  René M. Botnar,et al.  A fast 3D approach for coronary MRA , 1999, Journal of magnetic resonance imaging : JMRI.

[17]  P Börnert,et al.  Coronary artery imaging at 0.5 t using segmented 3d echo planar imaging , 1995, Magnetic resonance in medicine.

[18]  P. Börnert,et al.  Free-breathing cardiac MR imaging: study of implications of respiratory motion--initial results. , 2001, Radiology.

[19]  C H Lorenz,et al.  Blood pool agent strongly improves 3D magnetic resonance coronary angiography using an inversion pre‐pulse , 1999, Magnetic resonance in medicine.

[20]  D G Nishimura,et al.  Combined connectivity and a gray‐level morphological filter in magnetic resonance coronary angiography , 2000, Magnetic resonance in medicine.

[21]  René M. Botnar,et al.  Direct comparison of 3D spiral vs. Cartesian gradient‐echo coronary magnetic resonance angiography , 2001, Magnetic resonance in medicine.

[22]  René M. Botnar,et al.  Motion artifact reduction and vessel enhancement for free‐breathing navigator‐gated coronary MRA using 3D k‐space reordering , 2001, Magnetic resonance in medicine.

[23]  René M. Botnar,et al.  Selective three‐dimensional visualization of the coronary arterial lumen using arterial spin tagging , 2002, Magnetic resonance in medicine.

[24]  D G Nishimura,et al.  3D MR coronary artery segmentation , 1998, Magnetic resonance in medicine.

[25]  René M. Botnar,et al.  Submillimeter three-dimensional coronary MR angiography with real-time navigator correction: comparison of navigator locations. , 1999, Radiology.

[26]  P J de Feyter,et al.  Breath-hold coronary MR angiography with volume-targeted imaging. , 1998, Radiology.

[27]  P J de Feyter,et al.  Intravenous coronary angiography using electron beam computed tomography. , 1999, Progress in cardiovascular diseases.

[28]  René M. Botnar,et al.  Improved coronary artery definition with T2-weighted, free-breathing, three-dimensional coronary MRA. , 1999, Circulation.

[29]  B Geiger,et al.  An alternative method of three-dimensional reconstruction from two-dimensional CT and MR data sets. , 1991, European journal of radiology.

[30]  A. Dale,et al.  Cortical Surface-Based Analysis II: Inflation, Flattening, and a Surface-Based Coordinate System , 1999, NeuroImage.

[31]  R. Edelman,et al.  Coronary arteries: breath-hold MR angiography. , 1991, Radiology.

[32]  René M. Botnar,et al.  Double-oblique free-breathing high resolution three-dimensional coronary magnetic resonance angiography. , 1999, Journal of the American College of Cardiology.

[33]  R R Edelman,et al.  Coronary arteries: breath-hold, gadolinium-enhanced, three-dimensional MR angiography. , 1998, Radiology.

[34]  P. Boesiger,et al.  SENSE: Sensitivity encoding for fast MRI , 1999, Magnetic resonance in medicine.

[35]  F R Gutierrez,et al.  Coronary arteries: three-dimensional MR imaging with retrospective respiratory gating. , 1996, Radiology.

[36]  D. Firmin,et al.  Phase ordering with automatic window selection (PAWS): A novel motion‐resistant technique for 3D coronary imaging , 2000, Magnetic resonance in medicine.

[37]  G Laub,et al.  Coronary artery imaging: 3D segmented k‐space data acquisition with multiple breath‐holds and real‐time slab following , 2001, Journal of magnetic resonance imaging : JMRI.

[38]  G Laub,et al.  3D magnetization‐prepared true‐FISP: A new technique for imaging coronary arteries , 2001, Magnetic resonance in medicine.