Synthesis, Characterization and Biological Evaluation of Certain New Pyrazole Derivatives

A new series of substituted pyrazole derivatives were synthesised by 1,3,4-benzoxazinone with active hydrogen atoms of an amino group by conventional synthetic methods to form quinazolinone nucleus. These are further cyclized to prepare different pyrazoles by the reaction with appropriate cyclising agents like acetyl acetone. All the reactions are monitored by TLC technique and chemical tests as applicable. The structures of these compounds have been established by means of IR, proton NMR, Mass spectral analysis and elemental analysis. The compounds have been evaluated to determine their anti-tubercular profile and also were evaluated for antifungal and antimicrobial activity

[1]  Memy H Hassan,et al.  Synthesis and biological evaluation studies of novel quinazolinone derivatives as antibacterial and anti-inflammatory agents. , 2014, Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society.

[2]  Srinivasa,et al.  Synthesis and biological evaluation of tetrahydropyridinepyrazoles (‘PFPs’) as inhibitors of STAT3 phosphorylation , 2014 .

[3]  N. Aggarwal,et al.  Synthesis of some novel 4-arylidene pyrazoles as potential antimicrobial agents , 2013, Organic and medicinal chemistry letters.

[4]  F. Awadallah,et al.  New quinazolinone-pyrimidine hybrids: synthesis, anti-inflammatory, and ulcerogenicity studies. , 2012, European journal of medicinal chemistry.

[5]  E. Nosova,et al.  Synthesis and antiviral activity of fluorine-containing 4-arylaminoquinazolines , 2012, Pharmaceutical Chemistry Journal.

[6]  P. Petukhov,et al.  Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes. , 2011, Journal of medicinal chemistry.

[7]  A. Banerjee,et al.  Synthesis and antimalarial evaluation of some 4-quinazolinone derivatives based on febrifugine , 2010, Journal of advanced pharmaceutical technology & research.

[8]  K. El-Bayouki,et al.  Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1. , 2010, European journal of medicinal chemistry.

[9]  A. Klegeris,et al.  Synthesis and biological evaluation of novel pyrazole compounds. , 2010, Bioorganic & medicinal chemistry.

[10]  M. Khedr,et al.  Synthesis, biological evaluation and molecular docking of novel series of spiro [(2H,3H) quinazoline-2,1'- cyclohexan]-4(1H)- one derivatives as anti-inflammatory and analgesic agents. , 2010, European journal of medicinal chemistry.

[11]  R. Vadavi,et al.  A study of anti-inflammatory and analgesic activity of new 2,3-disubstituted 1,2-dihydroquinazolin-4(3h)-one derivative and its transition metal complexes. , 2010, Chemical & pharmaceutical bulletin.

[12]  A. Klegeris,et al.  Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents. , 2010, Bioorganic & medicinal chemistry.

[13]  H. Ashour,et al.  Synthesis and Biological Evaluation of Novel Pyrazoles and Pyrazolo[3,4‐d]pyrimidines Incorporating a Benzenesulfonamide Moiety , 2009, Archiv der Pharmazie.

[14]  S. Sridhar,et al.  Synthesis, antiviral and cytotoxic activity of 6-bromo-2,3-disubstituted-4(3H)-quinazolinones. , 2003, Biological & pharmaceutical bulletin.