[Continuous subcutaneous insulin infusion in the treatment of insulin-dependent diabetes mellitus].

Intensified insulin delivery has attained significant importance in the treatment of insulin-dependent diabetes to avoid microangiopathy involving the retina and kidney. 15 patients have been treated for periods from 2 month to 3 years, 2 years with continuous subcutaneous insulin infusion. All patients have better metabolic control than that achieved with conventional therapy. HbA1c decreased from 7.8% +/- 1.6 (SD) to 6.2% +/- 1.3 (normal value: 3.8-6.5%). Negative features of insulin-pump therapy include hyperglycemias after discontinuation of insulin infusion and cutaneous infection at the catheter site. No severe episodes of hypoglycemia were observed. Acceptability of pump treatment is good in our patients because of improved physical condition and the ability to pursue their usual activities.