A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease

[1]  Crispin J. Miller,et al.  GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1 , 2015, Nature Cell Biology.

[2]  P. Lundquist,et al.  Deletional HPFH Vs. Delta Beta Thalassemia: Closing in on a Possible Hb F Silencer Location , 2015 .

[3]  T. Möröy,et al.  Growth Factor Independence 1b (Gfi1b) Is Important for the Maturation of Erythroid Cells and the Regulation of Embryonic Globin Expression , 2014, PloS one.

[4]  S. Orkin,et al.  Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A , 2013, Proceedings of the National Academy of Sciences.

[5]  P. Sebastiani,et al.  Genetic modifiers of sickle cell disease , 2012, American journal of hematology.

[6]  P. Sebastiani,et al.  Fetal hemoglobin in sickle cell anemia: Molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans , 2012, American journal of hematology.

[7]  Ryan K. Dale,et al.  Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells. , 2011, Blood.

[8]  Li Liu,et al.  High-density SNP genotyping to define beta-globin locus haplotypes. , 2009, Blood cells, molecules & diseases.

[9]  M. McCarthy,et al.  Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes , 2008, Nature Genetics.

[10]  Gonçalo R. Abecasis,et al.  Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia , 2008, Proceedings of the National Academy of Sciences.

[11]  Simon Heath,et al.  A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15 , 2007, Nature Genetics.

[12]  T. Spector,et al.  Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults , 2007, Proceedings of the National Academy of Sciences.

[13]  G. Stamatoyannopoulos.  Control of globin gene expression during development and erythroid differentiation. , 2005, Experimental hematology.

[14]  T. Spector,et al.  Quantitative trait locus on chromosome 8q influences the switch from fetal to adult hemoglobin. , 2004, Blood.

[15]  L. Farrer,et al.  Polymorphisms near a chromosome 6q QTL area are associated with modulation of fetal hemoglobin levels in sickle cell anemia. , 2004, Cellular and molecular biology.

[16]  J. D. Engel,et al.  Looping, Linking, and Chromatin Minireview Activity: New Insights into b-globin Locus Regulation , 2000 .

[17]  L. Contu,et al.  The relative importance of the X‐linked FCP locus and β‐globin haplotypes in determining haemoglobin F levels: a study of SS patients homozygous for βS haplotypes , 1997, British journal of haematology.

[18]  G. Lathrop,et al.  Dissecting the loci controlling fetal haemoglobin production on chromosomes 11p and 6q by the regressive approach , 1996, Nature Genetics.

[19]  O. Platt,et al.  Mortality in sickle cell disease. Life expectancy and risk factors for early death. , 1994, The New England journal of medicine.

[20]  H. Meiselman,et al.  Beta-S gene cluster haplotypes modulate hematologic and hemorheologic expression in sickle cell anemia. Use in predicting clinical severity. , 1994, The American journal of pediatric hematology/oncology.

[21]  E Vichinsky,et al.  Pain in sickle cell disease. Rates and risk factors. , 1991, The New England journal of medicine.

[22]  R. Nagel,et al.  The Senegal DNA haplotype is associated with the amelioration of anemia in African-American sickle cell anemia patients. , 1991, Blood.

[23]  E. Rappaport,et al.  The Xmn I site (-158, C----T) 5' to the G gamma gene: correlation with the Senegalese haplotype and G gamma globin expression. , 1991, Hemoglobin.

[24]  J. Verter,et al.  Recruitment in the Cooperative Study of Sickle Cell Disease (CSSCD). , 1987, Controlled clinical trials.

[25]  D. Labie,et al.  The hematologic characteristics of sickle cell anemia bearing the Bantu haplotype: the relationship between G gamma and HbF level. , 1987, Blood.

[26]  A. Abeliovich,et al.  Identification of regulatory elements of human beta-like globin genes. , 1987, Progress in clinical and biological research.

[27]  James T. Elder,et al.  A developmentally stable chromatin structure in the human beta-globin gene cluster. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[28]  A. Kutlar,et al.  Hematological observations on Arabian SS patients with a homozygosity or heterozygosity for a beta S chromosome with haplotype #31. , 1985, Hemoglobin.