Acute hepatitis C transmitted by needlestick accident despite short duration interferon treatment

Hepatitis C virus (HCV) transmission by needlestick accidents involving hospital employees has become an important problem. The present report is of a case of acute hepatitis C that developed after a needlestick injury, despite short duration interferon treatment performed just after the accident in a trial effort to prevent HCV transmission. Nosocomial infection of HCV in medical employees is reviewed, and the current prospects for protecting them from HCV transmission after needlestick accident are discussed.

[1]  R. Miller,et al.  Lack of protective immunity against reinfection with hepatitis C virus. , 1993, Science.

[2]  K. Masuko,et al.  Hepatitis C virus infection in medical personnel after needlestick accident , 1992, Hepatology.

[3]  N. Ogata,et al.  Lack of protective immunity against reinfection with hepatitis C virus , 1992 .

[4]  R. Purcell,et al.  Detection of intrahepatic replication of hepatitis C virus RNA by in situ hybridization and comparison with histopathology. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[5]  O. Yokosuka,et al.  Resolution of acute hepatitis C after therapy with natural beta interferon , 1991, The Lancet.

[6]  R. Purcell,et al.  Hepatitis C in hospital employees with needlestick injuries. , 1991, Annals of internal medicine.

[7]  S. Mishiro,et al.  Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5'-noncoding region. , 1990, The Japanese journal of experimental medicine.

[8]  S. Banks,et al.  Recombinant interferon alfa therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial. , 1989, The New England journal of medicine.

[9]  Eugene R. Schiff,et al.  Treatment of Chronic Hepatitis C with Recombinant Interferon Alfa , 1989 .

[10]  A. Couroucé,et al.  [Immunoprophylaxis of viral hepatitis]. , 1981, La Nouvelle presse medicale.

[11]  L. Seeff Viral hepatitis. (Clinical gastroenterology monograph series) , 1979 .

[12]  J. Hoofnagle,et al.  Immunoprophylaxis of viral hepatitis. , 1979, Gastroenterology.

[13]  E. Schiff,et al.  Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter randomized, controlled trial. , 1989, The New England journal of medicine.