A sigma delta ISFET readout circuit for Lab-on-Chip applications

This paper presents a new ISFET readout interface circuitry for Lab-on-Chip applications. The proposed circuit features a dedicated DC-input sigma delta modulator converting the detected charge to 1-bit digital series. The proposed circuit, designed in 0.35-μm CMOS technology, offers a biologically relevant, high pH dynamic range of 5 to 9 and high sensitivity of 800mV/pH. We demonstrate the features of the proposed circuit by simulations and we discuss the advantage of this low complexity circuit for the measurement of pH using an array of ISFETs suitable for a variety of chemical and biological applications.