Alcohol and Mortality

Alcohol consumption has long been recognized as a risk factor for mortality. By combining data on alcohol per capita consumption, alcohol-drinking status and alcohol-drinking patterns, risk relationships, and mortality, the Comparative Risk Assessment Study estimated alcohol-attributable mortality for 1990 and 2010. Alcohol-attributable cancer, liver cirrhosis, and injury were responsible for the majority of the burden of alcohol-attributable mortality in 1990 and 2010. In 2010, alcohol-attributable cancer, liver cirrhosis, and injury caused 1,500,000 deaths (319,500 deaths among women and 1,180,500 deaths among men) and 51,898,400 potential years of life lost (PYLL) (9,214,300 PYLL among women and 42,684,100 PYLL among men). This represents 2.8 percent (1.3 percent for women and 4.1 percent for men) of all deaths and 3.0 percent (1.3 percent for women and 4.3 percent for men) of all PYLL in 2010. The absolute mortality burden of alcohol-attributable cancer, liver cirrhosis, and injury increased from 1990 to 2010 for both genders. In addition, the rates of deaths and PYLL per 100,000 people from alcohol-attributable cancer, liver cirrhosis, and injury increased from 1990 to 2010 (with the exception of liver cirrhosis rates for women). Results of this paper indicate that alcohol is a significant and increasing risk factor for the global burden of mortality.

[1]  J. Rehm,et al.  Elasticity of alcohol consumption, alcohol-related harms, and drinking initiation in low- and middle-income countries: A systematic review and meta-analysis , 2013 .

[2]  J. Rehm,et al.  Alcohol consumption and mortality in Russia since 2000: are there any changes following the alcohol policy changes starting in 2006? , 2013, Alcohol and alcoholism.

[3]  C. la Vecchia,et al.  Light alcohol drinking and cancer: a meta-analysis. , 2013, Annals of oncology : official journal of the European Society for Medical Oncology.

[4]  Alan D. Lopez,et al.  Age-specific and sex-specific mortality in 187 countries, 1970–2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.

[5]  Bernadette A. Thomas,et al.  Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.

[6]  Alan D. Lopez,et al.  A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.

[7]  Jürgen Rehm,et al.  The relationship between alcohol consumption and fatal motor vehicle injury: high risk at low alcohol levels. , 2012, Alcoholism, clinical and experimental research.

[8]  S. Kish,et al.  All-cause mortality among individuals with disorders related to the use of methamphetamine: a comparative cohort study. , 2012, Drug and alcohol dependence.

[9]  Jürgen Rehm,et al.  Comparative risk assessment of carcinogens in alcoholic beverages using the margin of exposure approach , 2012, International journal of cancer.

[10]  J. Rehm,et al.  Two-chosen-one taxation: examining its potential effectiveness to reduce drinking initiation and heavy alcohol consumption in low- to middle-income countries. , 2012, Addiction.

[11]  J. Rehm,et al.  The cardioprotective association of average alcohol consumption and ischaemic heart disease: a systematic review and meta-analysis. , 2012, Addiction.

[12]  J. Rehm,et al.  Global burden of injuries attributable to alcohol consumption in 2004: a novel way of calculating the burden of injuries attributable to alcohol consumption , 2012, Population Health Metrics.

[13]  G. Gmel,et al.  Determining the best population-level alcohol consumption model and its impact on estimates of alcohol-attributable harms , 2012, Population Health Metrics.

[14]  J. Rehm,et al.  Alcohol consumption, alcohol dependence, and attributable burden of disease in Europe: Potential gains from effective interventions for alcohol dependence , 2012 .

[15]  Andrea C. Fernandes,et al.  Associations between substance use disorder sub-groups, life expectancy and all-cause mortality in a large British specialist mental healthcare service. , 2011, Drug and alcohol dependence.

[16]  F. Gudé,et al.  Long-term mortality of patients admitted to the hospital with alcohol withdrawal syndrome. , 2011, Alcoholism, clinical and experimental research.

[17]  G. Borges,et al.  The more you drink, the harder you fall: a systematic review and meta-analysis of how acute alcohol consumption and injury or collision risk increase together. , 2010, Drug and alcohol dependence.

[18]  D. Chisholm,et al.  Effectiveness and cost-effectiveness of policies and programmes to reduce the harm caused by alcohol , 2009, The Lancet.

[19]  Jürgen Rehm,et al.  Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders , 2009, The Lancet.

[20]  L. Schmidt,et al.  Alcohol: equity and social determinants. , 2009 .

[21]  Adrian Angold,et al.  Transitions Into Underage and Problem Drinking: Developmental Processes and Mechanisms Between 10 and 15 Years of Age , 2008, Pediatrics.

[22]  S. Popova,et al.  Alcohol drinking cessation and its effect on esophageal and head and neck cancers: A pooled analysis , 2007, International journal of cancer.

[23]  K. Straif,et al.  Carcinogenicity of alcoholic beverages. , 2007, The Lancet. Oncology.

[24]  Colin Mathers,et al.  Comparative Quantification of Mortality and Burden of Disease Attributable to Selected Risk Factors , 2006 .

[25]  Kathryn M McDonald,et al.  Changes in rates of autopsy-detected diagnostic errors over time: a systematic review. , 2003, JAMA.

[26]  M J Eckardt,et al.  Effects of moderate alcohol consumption on the central nervous system. , 1998, Alcoholism: Clinical and Experimental Research.

[27]  B. Barraclough,et al.  Excess mortality of mental disorder , 1998, British Journal of Psychiatry.