Cell death in the gut epithelium and implications for chronic inflammation

[1]  Jiahuai Han,et al.  Gut stem cell necroptosis by genome instability triggers bowel inflammation , 2020, Nature.

[2]  M. Pasparakis,et al.  Z-nucleic acid sensing triggers ZBP1-dependent necroptosis and inflammation , 2020, Nature.

[3]  Kartik Gupta,et al.  Necroptosis in the Pathophysiology of Disease. , 2019, The American journal of pathology.

[4]  M. Pasparakis,et al.  Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis , 2019, Nature.

[5]  Rohit Reja,et al.  Activity of caspase-8 determines plasticity between cell death pathways , 2019, Nature.

[6]  Annaïg Lan,et al.  Hyperosmolar environment and intestinal epithelial cells: impact on mitochondrial oxygen consumption, proliferation, and barrier function in vitro , 2019, Scientific Reports.

[7]  M. Ohmuraya,et al.  Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis , 2019, iScience.

[8]  P. Vandenabeele,et al.  The molecular machinery of regulated cell death , 2019, Cell Research.

[9]  K. Chandy,et al.  Antibodies and venom peptides: new modalities for ion channels , 2019, Nature Reviews Drug Discovery.

[10]  P. Maini,et al.  Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation , 2019, Cell Death & Disease.

[11]  R. Ben-yosef,et al.  ARTS mediates apoptosis and regeneration of the intestinal stem cell niche , 2018, Nature Communications.

[12]  T. Vanden Berghe,et al.  Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis , 2018, Nature Communications.

[13]  F. He,et al.  C-type lectin receptor LSECtin-mediated apoptotic cell clearance by macrophages directs intestinal repair in experimental colitis , 2018, Proceedings of the National Academy of Sciences.

[14]  H. Tang,et al.  Correction to: ‘Anastasis: recovery from the brink of cell death’ , 2018, Royal Society Open Science.

[15]  A. Gasbarrini,et al.  IL-33 promotes recovery from acute colitis by inducing miR-320 to stimulate epithelial restitution and repair , 2018, Proceedings of the National Academy of Sciences.

[16]  J. Satsangi,et al.  Mitochondrial DNA Is a Pro-Inflammatory Damage-Associated Molecular Pattern Released During Active IBD. , 2018, Inflammatory bowel diseases.

[17]  John T. Chang,et al.  Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death , 2018, Proceedings of the National Academy of Sciences.

[18]  Yehua Li,et al.  Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death , 2018, PLoS genetics.

[19]  G. Barton,et al.  A Map of Toll‐like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type‐Specific, and Temporal Patterns , 2018, Immunity.

[20]  M. Maurice,et al.  Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer , 2018, Open Biology.

[21]  G. Diehl,et al.  Identifying the Patterns of Pattern Recognition Receptors. , 2018, Immunity.

[22]  J. Jaubert,et al.  Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice. , 2018, JCI insight.

[23]  S. Tenzer,et al.  Chronic intestinal inflammation in mice expressing viral Flip in epithelial cells , 2018, Mucosal Immunology.

[24]  Michelle C. Schaeffer,et al.  Caspase‐8 Collaborates with Caspase‐11 to Drive Tissue Damage and Execution of Endotoxic Shock , 2018, Immunity.

[25]  P. Achacoso,et al.  A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival , 2018, The Journal of experimental medicine.

[26]  K. Schroder,et al.  MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice , 2018, Scientific Reports.

[27]  Jing Yu,et al.  Oncosis-like cell death is induced by berberine through ERK1/2-mediated impairment of mitochondrial aerobic respiration in gliomas. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[28]  S. Baksh,et al.  Tumor necrosis factor α-induced protein 3 (A20) is dysregulated in pediatric Crohn disease , 2018, Clinical and experimental gastroenterology.

[29]  B. Finlay,et al.  A Nonpyroptotic IFN-γ–Triggered Cell Death Mechanism in Nonphagocytic Cells Promotes Salmonella Clearance In Vivo , 2018, The Journal of Immunology.

[30]  E. Parthoens,et al.  Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture , 2018, Cell Death & Differentiation.

[31]  Jian Yu,et al.  PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors , 2018, Proceedings of the National Academy of Sciences.

[32]  M. Neurath,et al.  Intestinal epithelial Caspase-8 signaling is essential to prevent necroptosis during Salmonella Typhimurium induced enteritis , 2018, Mucosal Immunology.

[33]  H. Tang,et al.  Detecting Anastasis In Vivo by CaspaseTracker Biosensor. , 2018, Journal of visualized experiments : JoVE.

[34]  R. Köhler,et al.  Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes , 2018, PloS one.

[35]  M. Lamkanfi,et al.  Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4 , 2017, Cell reports.

[36]  A. Lazenby,et al.  The Apoptotic Crypt Abscess: An Underappreciated Histologic Finding in Gastrointestinal Pathology , 2017, American journal of clinical pathology.

[37]  L. Bosurgi,et al.  Death begets a new beginning , 2017, Immunological reviews.

[38]  Yarden Katz,et al.  A single-cell survey of the small intestinal epithelium , 2017, Nature.

[39]  Yingying Zhang,et al.  Plasma membrane changes during programmed cell deaths , 2017, Cell Research.

[40]  R. Oehler,et al.  The immune response to secondary necrotic cells , 2017, Apoptosis.

[41]  Junying Yuan,et al.  Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis , 2017, Nature Communications.

[42]  Timothy A J Haystead,et al.  Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease. , 2017, Cell chemical biology.

[43]  X. Bian,et al.  High‐mobility group box 1 released by autophagic cancer‐associated fibroblasts maintains the stemness of luminal breast cancer cells , 2017, The Journal of pathology.

[44]  P A Kenny,et al.  Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells , 2017, Oncogene.

[45]  E. Hahm,et al.  Apoptosis and Compensatory Proliferation Signaling Are Coupled by CrkI-Containing Microvesicles. , 2017, Developmental cell.

[46]  B. Croker,et al.  Phosphatidylserine externalization, “necroptotic bodies” release, and phagocytosis during necroptosis , 2017, PLoS biology.

[47]  M. Bollati-Fogolín,et al.  Pro-inflammatory Ca++-activated K+ channels are inhibited by hydroxychloroquine , 2017, Scientific Reports.

[48]  K. Takeda,et al.  Roles of intestinal epithelial cells in the maintenance of gut homeostasis , 2017, Experimental &Molecular Medicine.

[49]  I. Brodsky,et al.  NAIP‐NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL‐18 Release via Activation of Caspase‐1 and ‐8 , 2017, Immunity.

[50]  D. Green,et al.  ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences , 2017, Cell.

[51]  Wenqing Gao,et al.  Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death. , 2017, Trends in biochemical sciences.

[52]  J. Haas,et al.  Inflammatory bowel disease following anti-interleukin-1-treatment in systemic juvenile idiopathic arthritis , 2017, Pediatric Rheumatology.

[53]  F. Abboud,et al.  The volume-regulated anion channel (LRRC8) in nodose neurons is sensitive to acidic pH. , 2017, JCI insight.

[54]  Seamus J. Martin,et al.  Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory "FADDosome" Complex upon TRAIL Stimulation. , 2017, Molecular cell.

[55]  K. Kosik,et al.  A molecular signature for anastasis, recovery from the brink of apoptotic cell death , 2017, bioRxiv.

[56]  H. Tang,et al.  Molecular signature of anastasis for reversal of apoptosis , 2017, F1000Research.

[57]  E. Alnemri,et al.  Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death , 2017, Nature Communications.

[58]  C. Lien,et al.  Epidermal growth factor suppresses intestinal epithelial cell shedding through a MAPK-dependent pathway , 2017, Journal of Cell Science.

[59]  S. Brant,et al.  The Pathogenic Role of NLRP3 Inflammasome Activation in Inflammatory Bowel Diseases of Both Mice and Humans , 2016, Journal of Crohn's & colitis.

[60]  F. Dalle,et al.  Enterocyte Purge and Rapid Recovery Is a Resilience Reaction of the Gut Epithelium to Pore-Forming Toxin Attack. , 2016, Cell host & microbe.

[61]  Boris M. Hartmann,et al.  Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs , 2016, Nature.

[62]  C. Parkos,et al.  Pathobiology of neutrophil–epithelial interactions , 2016, Immunological reviews.

[63]  Haifeng Yin,et al.  TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpoints , 2016, Cell Death and Disease.

[64]  Yi Wang,et al.  Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis , 2016, Cell Research.

[65]  E. Latz,et al.  HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins , 2016, Cellular & Molecular Immunology.

[66]  J. Lieberman,et al.  Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores , 2016, Nature.

[67]  M. Mitsuhashi,et al.  Luminal Extracellular Vesicles (EVs) in Inflammatory Bowel Disease (IBD) Exhibit Proinflammatory Effects on Epithelial Cells and Macrophages , 2016, Inflammatory bowel diseases.

[68]  V. Dixit,et al.  GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes , 2016, Proceedings of the National Academy of Sciences.

[69]  J. Jenkins,et al.  Secreted HMGB1 from Wnt activated intestinal cells is required to maintain a crypt progenitor phenotype , 2016, Oncotarget.

[70]  M. Neurath,et al.  Programming of Intestinal Epithelial Differentiation by IL-33 Derived from Pericryptal Fibroblasts in Response to Systemic Infection. , 2016, Cell reports.

[71]  Mark Bradley,et al.  Fluorogenic Substrates for In Situ Monitoring of Caspase-3 Activity in Live Cells , 2016, PloS one.

[72]  P. Vandenabeele,et al.  Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo. , 2016, Immunity.

[73]  K. Kunzelmann Ion channels in regulated cell death , 2016, Cellular and Molecular Life Sciences.

[74]  Zhaobing Gao,et al.  MLKL forms cation channels , 2016, Cell Research.

[75]  J. Ninomiya-Tsuji,et al.  TAK1 regulates Paneth cell integrity partly through blocking necroptosis , 2016, Cell Death and Disease.

[76]  D. Green,et al.  The clearance of dying cells: table for two , 2016, Cell Death and Differentiation.

[77]  U. Klein,et al.  NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions , 2016, Immunity.

[78]  K. Yagi,et al.  Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5 Expression , 2016, PloS one.

[79]  E. Elinav,et al.  Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis , 2015, Cell.

[80]  M. Bertrand,et al.  NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling. , 2015, Molecular cell.

[81]  S. Kummerfeld,et al.  Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling , 2015, Nature.

[82]  T. Cai,et al.  Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death , 2015, Nature.

[83]  R. Xavier,et al.  Role of Autophagy in the Maintenance of Intestinal Homeostasis. , 2015, Gastroenterology.

[84]  Judy H. Cho,et al.  Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations , 2015, Nature Genetics.

[85]  D. Green,et al.  Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3 , 2015, Nature Communications.

[86]  C. A. de la Motte,et al.  The epithelial danger signal IL-1α is a potent activator of fibroblasts and reactivator of intestinal inflammation. , 2015, The American journal of pathology.

[87]  E. Miao,et al.  Pyroptotic cell death defends against intracellular pathogens , 2015, Immunological reviews.

[88]  Z. Ling,et al.  The Endoplasmic Reticulum Stress Sensor IRE1α in Intestinal Epithelial Cells Is Essential for Protecting against Colitis* , 2015, The Journal of Biological Chemistry.

[89]  F. Chan,et al.  Programmed necrosis in the cross talk of cell death and inflammation. , 2015, Annual review of immunology.

[90]  H. Tang,et al.  In vivo CaspaseTracker biosensor system for detecting anastasis and non-apoptotic caspase activity , 2015, Scientific Reports.

[91]  Maryam Rashidi,et al.  RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL , 2015, Nature Communications.

[92]  H. Kiyonari,et al.  Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice , 2015, Gut.

[93]  H. Tang,et al.  Strategies for tracking anastasis, a cell survival phenomenon that reverses apoptosis. , 2015, Journal of visualized experiments : JoVE.

[94]  J. Ousingsawat,et al.  Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages , 2015, Nature Communications.

[95]  C. Rogel-Gaillard,et al.  Pattern recognition receptors in the gut: analysis of their expression along the intestinal tract and the crypt/villus axis , 2015, Physiological reports.

[96]  J. Lamb,et al.  Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation , 2014, Nature Communications.

[97]  N. Malhotra,et al.  The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair. , 2014, Immunity.

[98]  M. Pasparakis,et al.  RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis , 2014, Nature.

[99]  W. Hardt,et al.  Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa. , 2014, Cell host & microbe.

[100]  J. Celli,et al.  Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens. , 2014, Cell host & microbe.

[101]  J. Belizário,et al.  Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control , 2014, Mediators of inflammation.

[102]  H. Clevers,et al.  Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ , 2014, The Journal of experimental medicine.

[103]  M. Neurath,et al.  Caspase-8 controls the gut response to microbial challenges by Tnf-α-dependent and independent pathways , 2014, Gut.

[104]  M. Bertrand,et al.  MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates. , 2014, Cell reports.

[105]  M. Lamkanfi,et al.  Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulphate-induced colitis , 2014, Mucosal Immunology.

[106]  Hans Clevers,et al.  Adult Stem Cells in the Small Intestine Are Intrinsically Programmed with Their Location‐Specific Function , 2014, Stem cells.

[107]  Xiaodong Wang,et al.  Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. , 2014, Molecular cell.

[108]  K. Breitbach,et al.  Caspase-1-Dependent and -Independent Cell Death Pathways in Burkholderia pseudomallei Infection of Macrophages , 2014, PLoS pathogens.

[109]  J. Bertin,et al.  Necroptosis Is Active in Children With Inflammatory Bowel Disease and Contributes to Heighten Intestinal Inflammation , 2014, The American Journal of Gastroenterology.

[110]  Adriano G. Rossi,et al.  Apoptotic cell clearance: basic biology and therapeutic potential , 2014, Nature Reviews Immunology.

[111]  L. Galluzzi,et al.  MLKL regulates necrotic plasma membrane permeabilization , 2014, Cell Research.

[112]  Jiahuai Han,et al.  Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death , 2013, Cell Research.

[113]  Ling-gang Wu,et al.  Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis , 2013, Nature Cell Biology.

[114]  A. Kaser,et al.  ATG16L1 Crohn's disease risk stresses the endoplasmic reticulum of Paneth cells , 2013, Gut.

[115]  M. Neurath,et al.  Cellular FLICE-like inhibitory protein secures intestinal epithelial cell survival and immune homeostasis by regulating caspase-8. , 2013, Gastroenterology.

[116]  P. Michetti,et al.  Macrophages promote epithelial repair through hepatocyte growth factor secretion , 2013, Clinical and experimental immunology.

[117]  A. Kaser,et al.  Paneth cells as a site of origin for intestinal inflammation , 2013, Nature.

[118]  S. Orlov,et al.  Cell volume and monovalent ion transporters: their role in cell death machinery triggering and progression. , 2013, American journal of physiology. Cell physiology.

[119]  Seamus J. Martin,et al.  Distinguishing between apoptosis, necrosis, necroptosis and other cell death modalities. , 2013, Methods.

[120]  D. Andrews,et al.  Mechanisms of action of Bcl-2 family proteins. , 2013, Cold Spring Harbor perspectives in biology.

[121]  H. Steller,et al.  Shaping organisms with apoptosis , 2013, Cell Death and Differentiation.

[122]  Peter Vandenabeele,et al.  Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. , 2013, Immunity.

[123]  Andrew Kovalenko,et al.  Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome. , 2013, Immunity.

[124]  F. Chan Fueling the flames: Mammalian programmed necrosis in inflammatory diseases. , 2012, Cold Spring Harbor perspectives in biology.

[125]  A. Kieser,et al.  The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-κB by TRAIL , 2012, Cell Death and Disease.

[126]  Jos W. M. van der Meer,et al.  Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases , 2012, Nature Reviews Drug Discovery.

[127]  D. Montell,et al.  Cell survival, DNA damage, and oncogenic transformation after a transient and reversible apoptotic response , 2012, Molecular biology of the cell.

[128]  Chi-Bin Chien,et al.  Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia , 2012, Nature.

[129]  M. Heikenwalder,et al.  Salmonella Transiently Reside in Luminal Neutrophils in the Inflamed Gut , 2012, PloS one.

[130]  B. Finlay,et al.  Role of Inflammasomes in Host Defense against Citrobacter rodentium Infection* , 2012, The Journal of Biological Chemistry.

[131]  Min Yu,et al.  TAK1 Inhibition Promotes Apoptosis in KRAS-Dependent Colon Cancers , 2012, Cell.

[132]  P. Kongsuphol,et al.  Expression and function of epithelial anoctamins , 2012, Experimental physiology.

[133]  R. Odze,et al.  Clinical and pathological analysis of colonic Crohn's disease, including a subgroup with ulcerative colitis-like features , 2012, Modern Pathology.

[134]  Yuqiong Liang,et al.  Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3–mediated pathway , 2011, Proceedings of the National Academy of Sciences.

[135]  Jinfeng Liu,et al.  Non-canonical inflammasome activation targets caspase-11 , 2011, Nature.

[136]  Vanesa Fernández-Majada,et al.  FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation , 2011, Nature.

[137]  Helmut Neumann,et al.  Caspase-8 regulates TNF-alpha induced epithelial necroptosis and terminal ileitis , 2011, Nature.

[138]  N. Rooijen,et al.  SHIP‐deficient, alternatively activated macrophages protect mice during DSS‐induced colitis , 2011, Journal of leukocyte biology.

[139]  A. Watson,et al.  The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. , 2011, Gastroenterology.

[140]  B. Lambrecht,et al.  Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation. , 2011, Trends in immunology.

[141]  R. Pérez,et al.  Anti-NeuGcGM3 Antibodies, Actively Elicited by Idiotypic Vaccination in Nonsmall Cell Lung Cancer Patients, Induce Tumor Cell Death by an Oncosis-Like Mechanism , 2011, The Journal of Immunology.

[142]  Manuel T. Silva Secondary necrosis: The natural outcome of the complete apoptotic program , 2010, FEBS letters.

[143]  C. Fiocchi,et al.  Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis , 2010, Proceedings of the National Academy of Sciences.

[144]  D. McKay,et al.  In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice. , 2010, Gastroenterology.

[145]  Junying Yuan,et al.  Necroptosis as an alternative form of programmed cell death. , 2010, Current opinion in cell biology.

[146]  Fang Li,et al.  Apoptotic Cells Activate the “Phoenix Rising” Pathway to Promote Wound Healing and Tissue Regeneration , 2010, Science Signaling.

[147]  Maria T. Abreu,et al.  Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function , 2010, Nature Reviews Immunology.

[148]  H. Wulff,et al.  Inhibition of the K+ channel KCa3.1 ameliorates T cell–mediated colitis , 2010, Proceedings of the National Academy of Sciences.

[149]  P. Kongsuphol,et al.  Expression and Function of Epithelial Anoctamins* , 2010, The Journal of Biological Chemistry.

[150]  Hong-li Song,et al.  The roles of tumor necrosis factor-alpha in colon tight junction protein expression and intestinal mucosa structure in a mouse model of acute liver failure , 2009, BMC gastroenterology.

[151]  J. Tschopp,et al.  DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF‐κB , 2009, EMBO reports.

[152]  T. Tsuruo,et al.  Intestinal epithelial cancer cell anoikis resistance: EGFR‐mediated sustained activation of Src overrides Fak‐dependent signaling to MEK/Erk and/or PI3‐K/Akt‐1 , 2009, Journal of cellular biochemistry.

[153]  H. Clevers,et al.  Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche , 2009, Nature.

[154]  A. Clarke,et al.  Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation , 2008, Oncogene.

[155]  T. Mak,et al.  Activation of noncanonical NF-κB requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2, TRAF3 and the kinase NIK , 2008, Nature Immunology.

[156]  H. Tilg,et al.  XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease , 2008, Cell.

[157]  J. Waring,et al.  Both cIAP1 and cIAP2 regulate TNFα-mediated NF-κB activation , 2008, Proceedings of the National Academy of Sciences.

[158]  S. Akira,et al.  Enterocyte-Derived TAK1 Signaling Prevents Epithelium Apoptosis and the Development of Ileitis and Colitis1 , 2008, The Journal of Immunology.

[159]  D. Green,et al.  Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3 , 2008, Cell.

[160]  Xiaodong Wang,et al.  TNF-α Induces Two Distinct Caspase-8 Activation Pathways , 2008, Cell.

[161]  J. Minna,et al.  Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. , 2007, Cancer cell.

[162]  H. Clevers,et al.  Identification of stem cells in small intestine and colon by marker gene Lgr5 , 2007, Nature.

[163]  G Gerken,et al.  Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. , 2007, Gastroenterology.

[164]  M. Neurath,et al.  Epithelial NEMO links innate immunity to chronic intestinal inflammation , 2007, Nature.

[165]  N. Pryer,et al.  The glycotope-specific RAV12 monoclonal antibody induces oncosis in vitro and has antitumor activity against gastrointestinal adenocarcinoma tumor xenografts in vivo , 2007, Molecular Cancer Therapeutics.

[166]  Fiona Campbell,et al.  Characterization of epithelial cell shedding from human small intestine , 2006, Laboratory Investigation.

[167]  J. Theriot,et al.  Listeria monocytogenes Invades the Epithelial Junctions at Sites of Cell Extrusion , 2006, PLoS pathogens.

[168]  C. Elia,et al.  Apoptosis in the intestinal mucosa of patients with inflammatory bowel disease: evidence of altered expression of FasL and perforin cytotoxic pathways , 2005, International Journal of Colorectal Disease.

[169]  Jason M Doherty,et al.  Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[170]  S. Anant,et al.  Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. , 2004, The Journal of clinical investigation.

[171]  Xiaomin Wang,et al.  Leukocyte elastase induces epithelial apoptosis: role of mitochondial permeability changes and Akt. , 2004, American journal of physiology. Gastrointestinal and liver physiology.

[172]  A. Lacy-Hulbert,et al.  Apoptotic Cells and Innate Immune Stimuli Combine to Regulate Macrophage Cytokine Secretion 1 , 2003, The Journal of Immunology.

[173]  Michael Field,et al.  Intestinal ion transport and the pathophysiology of diarrhea. , 2003, The Journal of clinical investigation.

[174]  R. Odze,et al.  Diagnostic Problems and Advances in Inflammatory Bowel Disease , 2003, Modern Pathology.

[175]  A. Kraker,et al.  Src activation regulates anoikis in human colon tumor cell lines , 2002, Oncogene.

[176]  T. Misteli,et al.  Release of chromatin protein HMGB1 by necrotic cells triggers inflammation , 2002, Nature.

[177]  H. Kudo,et al.  Increase in colorectal epithelial apoptotic cells in patients with ulcerative colitis ultimately requiring surgery , 2002, Journal of gastroenterology and hepatology.

[178]  N. Arizono,et al.  Activation of caspases in intestinal villus epithelial cells of normal and nematode infected rats , 2002, Gut.

[179]  Peter Scheurich,et al.  NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling , 2001, Molecular and Cellular Biology.

[180]  J. Sträter,et al.  Expression and Function of Death Receptors and Their Natural Ligands in the Intestine , 2000, Annals of the New York Academy of Sciences.

[181]  D. Podolsky,et al.  Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease , 2000, Infection and Immunity.

[182]  T. van der Wijk,et al.  Signalling Mechanisms Involved in Volume Regulation of Intestinal Epithelial Cells , 2000, Cellular Physiology and Biochemistry.

[183]  E. Levy,et al.  Butyrate mediates Caco-2 cell apoptosis via up-regulation of pro-apoptotic BAK and inducing caspase-3 mediated cleavage of poly-(ADP-ribose) polymerase (PARP) , 1999, Cell Death and Differentiation.

[184]  C. Bortner,et al.  A necessary role for cell shrinkage in apoptosis. , 1998, Biochemical pharmacology.

[185]  J. M. Kim,et al.  Apoptosis of human intestinal epithelial cells after bacterial invasion. , 1998, The Journal of clinical investigation.

[186]  Junying Yuan,et al.  Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE , 1998, Cell.

[187]  V. Fadok,et al.  Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. , 1998, The Journal of clinical investigation.

[188]  Y. Matsuzawa,et al.  Role of heparin‐binding EGF‐related peptides in proliferation and apoptosis of activated ras‐stimulated intestinal epithelial cells , 1997 .

[189]  R. Voll,et al.  Immunosuppressive effects of apoptotic cells , 1997, Nature.

[190]  F. Lang,et al.  Inhibition of Fas-induced apoptotic cell death by osmotic cell shrinkage. , 1997, Biochemical and biophysical research communications.

[191]  K. Koretz,et al.  CD95 (APO-1/Fas)-mediated apoptosis in colon epithelial cells: a possible role in ulcerative colitis. , 1997, Gastroenterology.

[192]  J. Tschopp,et al.  Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors , 1997, Nature.

[193]  I. K. Berezesky,et al.  The Pathways of Cell Death: Oncosis, Apoptosis, and Necrosis , 1997, Toxicologic pathology.

[194]  S. Moss,et al.  Increased small intestinal apoptosis in coeliac disease. , 1996, Gut.

[195]  T. Koji,et al.  APOPTOSIS OF CRYPT EPITHELIAL CELLS IN ULCERATIVE COLITIS , 1996, The Journal of pathology.

[196]  P. Möller,et al.  Paneth cells express high levels of CD95 ligand transcripts: a unique property among gastrointestinal epithelia. , 1996, The American journal of pathology.

[197]  Hong-Bing Shu,et al.  TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways , 1996, Cell.

[198]  M. Peter,et al.  Cytotoxicity‐dependent APO‐1 (Fas/CD95)‐associated proteins form a death‐inducing signaling complex (DISC) with the receptor. , 1995, The EMBO journal.

[199]  T. Iwanaga,et al.  The fate of effete epithelial cells at the villus tips of the human small intestine. , 1995, Archives of histology and cytology.

[200]  James L. Madara,et al.  Maintenance of the macromolecular barrier at cell extrusion sites in intestinal epithelium: Physiological rearrangement of tight junctions , 1990, The Journal of Membrane Biology.

[201]  M. Tanaka,et al.  The pathological diagnosis and differential diagnosis of Crohn's disease. , 1990, Hepato-gastroenterology.

[202]  V. Echavé,et al.  Acute necrosis of the intestinal mucosa with high serum levels of diamine oxidase , 1984, Digestive Diseases and Sciences.

[203]  G. Bounous Acute necrosis of the intestinal mucosa. , 1982, Gastroenterology.

[204]  J F Kerr,et al.  Shrinkage necrosis: A distinct mode of cellular death , 1971, The Journal of pathology.

[205]  H. Clevers,et al.  Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency. , 2019, Gastroenterology.

[206]  H. Tang,et al.  Molecular signature of anastasis for reversal of apoptosis. , 2017, F1000Research.

[207]  Judy H. Cho,et al.  Materials for : Host-microbe interactions shape genetic risk for inflammatory bowel disease , 2012 .

[208]  H. D. de Jonge,et al.  Osmosignaling and volume regulation in intestinal epithelial cells. , 2007, Methods in enzymology.

[209]  M. Walport,et al.  C1q, autoimmunity and apoptosis. , 2002, Immunobiology.

[210]  Kazuma Fujimoto,et al.  Programmed cell death in rat intestine: effect of feeding and fasting. , 2001, Scandinavian journal of gastroenterology.

[211]  D. Häussinger,et al.  Functional significance of cell volume regulatory mechanisms. , 1998, Physiological reviews.