Aurora A polyubiquitinates the BRCA1-interacting protein OLA1 to promote centrosome maturation.

[1]  Akinori Endo,et al.  cIAP1-based degraders induce degradation via branched ubiquitin architectures , 2022, Nature Chemical Biology.

[2]  Y. Miki,et al.  BRCA1 transports the DNA damage signal for CDDP‐induced centrosome amplification through the centrosomal Aurora A , 2022, Cancer science.

[3]  A. Castro,et al.  Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry , 2021, Nature Communications.

[4]  B. Kuster,et al.  PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase , 2020, Nature Chemical Biology.

[5]  N. Chiba,et al.  The Function of BARD1 in Centrosome Regulation in Cooperation with BRCA1/OLA1/RACK1 , 2020, Genes.

[6]  P. Sung,et al.  The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication , 2020, Nature Reviews Molecular Cell Biology.

[7]  N. Chiba,et al.  RACK1 regulates centriole duplication through promoting the activation of polo-like kinase 1 by Aurora A , 2020, Journal of Cell Science.

[8]  Daisuke Takao,et al.  The Cep57-pericentrin module organizes PCM expansion and centriole engagement , 2019, Nature Communications.

[9]  A. Yasui,et al.  RACK1 regulates centriole duplication by controlling localization of BRCA1 to the centrosome in mammary tissue-derived cells , 2019, Oncogene.

[10]  A. De Nicolo,et al.  Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis , 2018, Science Signaling.

[11]  C. Ishioka,et al.  BRCA1-Interacting Protein OLA1 Requires Interaction with BARD1 to Regulate Centrosome Number , 2018, Molecular Cancer Research.

[12]  E. Nigg,et al.  Once and only once: mechanisms of centriole duplication and their deregulation in disease , 2018, Nature Reviews Molecular Cell Biology.

[13]  C. Prigent,et al.  Aurora A Kinase Is a Priority Pharmaceutical Target for the Treatment of Cancers. , 2017, Trends in pharmacological sciences.

[14]  C. Miranti,et al.  A streamlined method for the design and cloning of shRNAs into an optimized Dox-inducible lentiviral vector , 2017, BMC Biotechnology.

[15]  Feimeng Zheng,et al.  Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype , 2016, Nature Communications.

[16]  I. A. Asteriti,et al.  Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly , 2015, Front. Oncol..

[17]  K. Rhee,et al.  PLK1 regulation of PCNT cleavage ensures fidelity of centriole separation during mitotic exit , 2015, Nature Communications.

[18]  P. Gönczy.  Centrosomes and cancer: revisiting a long-standing relationship , 2015, Nature Reviews Cancer.

[19]  Mi-young Seo,et al.  Integrity of the Pericentriolar Material Is Essential for Maintaining Centriole Association during M Phase , 2015, PloS one.

[20]  J. Raff,et al.  Centrosome function and assembly in animal cells , 2015, Nature Reviews Molecular Cell Biology.

[21]  N. Chiba,et al.  Regulation of the centrosome cycle , 2015, Molecular & cellular oncology.

[22]  L. James,et al.  Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21 , 2015, Proceedings of the National Academy of Sciences.

[23]  Kyung S. Lee,et al.  Bimodal Interaction of Mammalian Polo-Like Kinase 1 and a Centrosomal Scaffold, Cep192, in the Regulation of Bipolar Spindle Formation , 2015, Molecular and Cellular Biology.

[24]  P. Jallepalli,et al.  Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing , 2014, Nature Cell Biology.

[25]  Deli Zhang,et al.  BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1 , 2014, Cell cycle.

[26]  Q. Jiang,et al.  The role of mitotic kinases in coupling the centrosome cycle with the assembly of the mitotic spindle , 2014, Journal of Cell Science.

[27]  J. Walter,et al.  The Cep192-organized aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly. , 2014, Molecular cell.

[28]  A. Yasui,et al.  The BRCA1/BARD1-interacting protein OLA1 functions in centrosome regulation. , 2014, Molecular cell.

[29]  H. Gu,et al.  Association between the STK15 F31I Polymorphism and Cancer Susceptibility: A Meta-Analysis Involving 43,626 Subjects , 2013, PloS one.

[30]  Alexander Dammermann,et al.  Multiple Mechanisms Contribute to Centriole Separation in C. elegans , 2013, Current Biology.

[31]  Roland L. Dunbrack,et al.  Aurora A kinase (AURKA) in normal and pathological cell division , 2013, Cellular and Molecular Life Sciences.

[32]  J. Lüders,et al.  The amorphous pericentriolar cloud takes shape , 2012, Nature Cell Biology.

[33]  K. Hanashiro,et al.  Analysis of centrosome localization of BRCA1 and its activity in suppressing centrosomal aster formation , 2012, Cell cycle.

[34]  Steven J. M. Jones,et al.  Comprehensive molecular portraits of human breast tumors , 2012, Nature.

[35]  K. Rhee,et al.  Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis , 2012, Cell cycle.

[36]  Y. Ono,et al.  Kendrin Is a Novel Substrate for Separase Involved in the Licensing of Centriole Duplication , 2012, Current Biology.

[37]  J. Parvin,et al.  Functional differences among BRCA1 missense mutations in the control of centrosome duplication , 2012, Oncogene.

[38]  N. Verstraeten,et al.  The Universally Conserved Prokaryotic GTPases , 2011, Microbiology and Molecular Reviews.

[39]  Benjamin J. Raphael,et al.  Integrated Genomic Analyses of Ovarian Carcinoma , 2011, Nature.

[40]  M. Toya,et al.  A kinase-independent role for Aurora A in the assembly of mitotic spindle microtubules in Caenorhabditis elegans embryos , 2011, Nature Cell Biology.

[41]  R. Hammer,et al.  CDK5RAP2 regulates centriole engagement and cohesion in mice. , 2010, Developmental cell.

[42]  J. Montalbano,et al.  DOC45, a Novel DNA Damage–Regulated Nucleocytoplasmic ATPase That Is Overexpressed in Multiple Human Malignancies , 2010, Molecular Cancer Research.

[43]  Yang Wang,et al.  BRCA1 Interaction of Centrosomal Protein Nlp Is Required for Successful Mitotic Progression*♦ , 2009, The Journal of Biological Chemistry.

[44]  D. Finley,et al.  Recognition and processing of ubiquitin-protein conjugates by the proteasome. , 2009, Annual review of biochemistry.

[45]  M. Bertrand,et al.  cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. , 2008, Molecular cell.

[46]  J. Parvin,et al.  Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation. , 2007, Cancer research.

[47]  Alfred Wittinghofer,et al.  Human OLA1 Defines an ATPase Subfamily in the Obg Family of GTP-binding Proteins* , 2007, Journal of Biological Chemistry.

[48]  F. Chan,et al.  The N-terminal domain of the Aurora-A Phe-31 variant encodes an E3 ubiquitin ligase and mediates ubiquitination of IκBα , 2006 .

[49]  L. Starita,et al.  Identification of domains of BRCA1 critical for the ubiquitin-dependent inhibition of centrosome function. , 2006, Cancer research.

[50]  J. Parvin,et al.  Inhibition of BRCA1 in breast cell lines causes the centrosome duplication cycle to be disconnected from the cell cycle , 2006, Oncogene.

[51]  E. Nigg,et al.  Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome , 2005, Journal of Cell Science.

[52]  L. Starita,et al.  Centrosomal Microtubule Nucleation Activity Is Inhibited by BRCA1-Dependent Ubiquitination , 2005, Molecular and Cellular Biology.

[53]  A. Horwitz,et al.  BRCA1/BARD1 Ubiquitinate Phosphorylated RNA Polymerase II* , 2005, Journal of Biological Chemistry.

[54]  M. Kimura,et al.  Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk. , 2005, Cancer research.

[55]  Steven P. Gygi,et al.  BRCA1-Dependent Ubiquitination of γ-Tubulin Regulates Centrosome Number , 2004, Molecular and Cellular Biology.

[56]  H. Saya,et al.  Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells , 2003, Cell.

[57]  Hiroki Nagase,et al.  Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human , 2003, Nature Genetics.

[58]  G. Gilliland,et al.  Crystal Structure of the YchF Protein Reveals Binding Sites for GTP and Nucleic Acid , 2003, Journal of bacteriology.

[59]  P. Meraldi,et al.  Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. , 2003, Developmental cell.

[60]  Roman Körner,et al.  Human TPX2 is required for targeting Aurora-A kinase to the spindle , 2002, The Journal of cell biology.

[61]  Detlef D. Leipe,et al.  Classification and evolution of P-loop GTPases and related ATPases. , 2002, Journal of molecular biology.

[62]  P. Meraldi,et al.  Aurora‐A overexpression reveals tetraploidization as a major route to centrosome amplification in p53−/− cells , 2002, The EMBO journal.

[63]  S. Nakajima,et al.  Cellular Responses and Repair of Single-strand Breaks Introduced by UV Damage Endonuclease in Mammalian Cells* , 2000, The Journal of Biological Chemistry.

[64]  H. Leonhardt,et al.  Dynamics of DNA Replication Factories in Living Cells , 2000, The Journal of cell biology.

[65]  Brian Schryver,et al.  A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers , 1998, The EMBO journal.

[66]  A. Schwartz,et al.  Linkage of the ubiquitin‐conjugating system and the endocytic pathway in ligand‐induced internalization of the growth hormone receptor , 1997, The EMBO journal.

[67]  Anne M. Bowcock,et al.  Identification of a RING protein that can interact in vivo with the BRCA1 gene product , 1996, Nature Genetics.

[68]  E. Nigg,et al.  Cell Cycle: The NIMA kinase joins forces with Cdc2 , 1995, Current Biology.

[69]  Steven E. Bayer,et al.  A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. , 1994, Science.

[70]  D. Ecker,et al.  A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. , 1989, Science.