Systemic and acute administration of parathyroid hormone-related peptide(1–36) stimulates endogenous beta cell proliferation while preserving function in adult mice
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A. F. Stewart | R. Vasavada | A. García-Ocaña | A. Bisello | S. Joshi-Gokhale | K. Williams | D. Abanquah | A. Otero | H. Lin | N. K. Guthalu | X. Zhang | A. Mozar
[1] A. F. Stewart,et al. Parathyroid Hormone–Related Protein Enhances Human β-Cell Proliferation and Function With Associated Induction of Cyclin-Dependent Kinase 2 and Cyclin E Expression , 2010, Diabetes.
[2] C. Clar,et al. Newer agents for blood glucose control in type 2 diabetes: systematic review and economic evaluation. , 2010, Health technology assessment.
[3] S. Sereika,et al. Parathyroid hormone-related protein for the treatment of postmenopausal osteoporosis: defining the maximal tolerable dose. , 2010, The Journal of clinical endocrinology and metabolism.
[4] R. Bergenstal,et al. Clinical application of incretin-based therapy: therapeutic potential, patient selection and clinical use. , 2009, European journal of internal medicine.
[5] A. F. Stewart,et al. Mutant parathyroid hormone-related protein, devoid of the nuclear localization signal, markedly inhibits arterial smooth muscle cell cycle and neointima formation by coordinate up-regulation of p15Ink4b and p27kip1. , 2009, Endocrinology.
[6] D. Miao,et al. Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein , 2008, Proceedings of the National Academy of Sciences.
[7] R. Rizza,et al. β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans , 2008, Diabetes.
[8] R. Mirmira. Faculty Opinions recommendation of Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. , 2008 .
[9] Xueying Gu,et al. Menin Controls Growth of Pancreatic ß-Cells in Pregnant Mice and Promotes Gestational Diabetes Mellitus , 2007, Science.
[10] P. A. Friedman,et al. Protein Kinase C-ζ Activation Markedly Enhances β-Cell Proliferation , 2007, Diabetes.
[11] D. Melton,et al. Recovery from diabetes in mice by β cell regeneration , 2007 .
[12] C. Chen,et al. Cyclin D1 as a Target for the Proliferative Effects of PTH and PTHrP in Early Osteoblastic Cells , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[13] J. Kushner,et al. Growth and regeneration of adult beta cells does not involve specialized progenitors. , 2007, Developmental cell.
[14] B. Sicari,et al. Cellular Mechanism Through Which Parathyroid Hormone–Related Protein Induces Proliferation in Arterial Smooth Muscle Cells: Definition of an Arterial Smooth Muscle PTHrP/p27kip1 Pathway , 2006, Circulation research.
[15] I. Cózar-Castellano,et al. Growth factors and beta cell replication. , 2006, The international journal of biochemistry & cell biology.
[16] N. Greig,et al. In vivo biological activity of exendin (1–30) , 2005, Endocrine.
[17] J. Lakey,et al. Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass. , 2005, The Journal of clinical endocrinology and metabolism.
[18] R. Vasavada,et al. Characterization of mice doubly transgenic for parathyroid hormone-related protein and murine placental lactogen: a novel role for placental lactogen in pancreatic beta-cell survival. , 2004, Diabetes.
[19] M. Prentki,et al. A Pentadecapeptide Fragment of Islet Neogenesis-Associated Protein Increases Beta-Cell Mass and Reverses Diabetes in C57BL/6J Mice , 2004, Annals of surgery.
[20] S. Hino,et al. In vivo proliferation of differentiated pancreatic islet beta cells in transgenic mice expressing mutated cyclin-dependent kinase 4 , 2004, Diabetologia.
[21] G. Sandusky,et al. Bone Neoplasms in F344 Rats Given Teriparatide [rhPTH(1-34)] Are Dependent on Duration of Treatment and Dose , 2004, Toxicologic pathology.
[22] H. E. Maclean,et al. The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes. , 2004, The Journal of clinical investigation.
[23] I. Rooman,et al. Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan , 2004, Diabetologia.
[24] P. Roberson,et al. Proteasomal Degradation of Runx2 Shortens Parathyroid Hormone-induced Anti-apoptotic Signaling in Osteoblasts , 2003, Journal of Biological Chemistry.
[25] B. Pakkenberg,et al. The endocrine pancreas in non‐diabetic rats after short‐term and long‐term treatment with the long‐acting GLP‐1 derivative NN2211 , 2003, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.
[26] Masato Ogata,et al. Parathyroid hormone-related protein induces insulin expression through activation of MAP kinase-specific phosphatase-1 that dephosphorylates c-Jun NH2-terminal kinase in pancreatic beta-cells. , 2003, Diabetes.
[27] R. L. Cain,et al. Anabolic and catabolic bone effects of human parathyroid hormone (1-34) are predicted by duration of hormone exposure. , 2003, Bone.
[28] E. Gruenstein,et al. Midgestational lethality in mice lacking the parathyroid hormone (PTH)/PTH-related peptide receptor is associated with abrupt cardiomyocyte death. , 2003, Endocrinology.
[29] A. F. Stewart,et al. Short-term, high-dose parathyroid hormone-related protein as a skeletal anabolic agent for the treatment of postmenopausal osteoporosis. , 2003, The Journal of clinical endocrinology and metabolism.
[30] I. Rooman,et al. Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue. , 2002, Diabetes.
[31] C. Albanese,et al. TGFbeta and PTHrP control chondrocyte proliferation by activating cyclin D1 expression. , 2001, Molecular biology of the cell.
[32] M. Permutt,et al. Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia , 2001 .
[33] R. L. Cain,et al. Six‐Month Daily Administration of Parathyroid Hormone and Parathyroid Hormone—Related Protein Peptides to Adult Ovariectomized Rats Markedly Enhances Bone Mass and Biomechanical Properties: A Comparison of Human Parathyroid Hormone 1–34, Parathyroid Hormone‐Related Protein 1–36, and SDZ‐Parathyroid , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[34] P. Esbrit,et al. Parathyroid hormone-related peptide stimulates DNA synthesis and insulin secretion in pancreatic islets. , 1999, The Journal of endocrinology.
[35] T. Gardella,et al. Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via the type 1 PTH receptor: implications for design of signal-specific PTH ligands. , 1999, Biochemistry.
[36] A. F. Stewart,et al. Progressive pancreatic islet hyperplasia in the islet-targeted, parathyroid hormone-related protein-overexpressing mouse. , 1998, Endocrinology.
[37] J. Roume,et al. Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia. , 1998, The Journal of clinical investigation.
[38] F. R. Bringhurst,et al. Mechanisms of homologous and heterologous desensitization of PTH/PTHrP receptor signaling in LLC-PK1 cells. , 1997, The American journal of physiology.
[39] A. F. Stewart,et al. Structural and Physiologic Characterization of the Mid-region Secretory Species of Parathyroid Hormone-related Protein* , 1996, Journal of Biological Chemistry.
[40] A. F. Stewart,et al. Overexpression of Parathyroid Hormone-related Protein in the Pancreatic Islets of Transgenic Mice Causes Islet Hyperplasia, Hyperinsulinemia, and Hypoglycemia (*) , 1996, The Journal of Biological Chemistry.
[41] J Glowacki,et al. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. , 1994, Genes & development.
[42] D. Drucker,et al. Parathyroid hormone-like peptide in normal and neoplastic human endocrine tissues. , 1990, The Journal of clinical endocrinology and metabolism.
[43] D. Drucker,et al. The parathyroid hormone-like peptide gene is expressed in the normal and neoplastic human endocrine pancreas. , 1989, Molecular endocrinology.
[44] S. Efrat. Ex-vivo Expansion of Adult Human Pancreatic Beta-Cells. , 2008, The review of diabetic studies : RDS.
[45] D. Melton,et al. Recovery from diabetes in mice by beta cell regeneration. , 2007, The Journal of clinical investigation.
[46] Yuval Dor,et al. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. , 2004, Nature.
[47] M. Permutt,et al. Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. , 2001, The Journal of clinical investigation.
[48] T. Kameya,et al. Proprotein-processing endoprotease furin and its substrate parathyroid hormone-related protein are coexpressed in insulinoma cells , 2000, Endocrine pathology.
[49] J. Orloff,et al. Defining the roles of parathyroid hormone-related protein in normal physiology. , 1996, Physiological reviews.
[50] G. Maor,et al. Printed in U.S.A. Copyright © 1998 by The Endocrine Society In Vivo Anabolic Effects of Parathyroid Hormone (PTH) 28–48 and N-Terminal Fragments of PTH and PTH- Related Protein on Neonatal Mouse Bones* , 2022 .