Effect of age on the response of the left ventricular ejection fraction to exercise.

To assess the effects of age on the left ventricular ejection fraction (LVEF), we performed radionuclide angiocardiography at rest and during upright bicycle exercise in 77 healthy volunteers 20 to 95 years of age. Radionuclide measurements included left ventricular ejection fraction, end-diastolic volume, and regional wall motion. Age did not appear to influence any of these indexes at rest. However, during exercise the ejection fraction was less than 0.60 in 45 per cent of subjects over age 60 as compared with 2 per cent of younger subjects (P < 0.001). In addition, there was a decline in the change in LVEF (exercise LVEF minus rest LVEF) with increase in age (r = -0.71). Wall-motion abnormalities during exercise occurred with increasing frequency in patients who were 50 and older. In the older subjects these age-related changes in ejection fraction during exercise were not associated with differences in end-diastolic volume or blood pressure.

[1]  G. E. Newman,et al.  Detecting Abnormalities in Left Ventricular Function During Exercise Before Angina and ST‐segment Depression , 1980, Circulation.

[2]  G. E. Newman,et al.  The Reproducibility of Radionuclide Angiographic Measurements of Left Ventricular Function in Normal Subjects at Rest and During Exercise , 1980, Circulation.

[3]  J. Ritchie,et al.  Serial Exercise Radionuclide Angiography: Validation of Count–derived Changes in Cardiac Output and Quantitation of Maximal Exercise Ventricular Volume Change after Nitroglycerin and Propranolol in Normal Men , 1980, Circulation.

[4]  R. Jones,et al.  Effects of Propranolol on Left Ventricular Function in Normal Men , 1980, Circulation.

[5]  G S Johnston,et al.  Sensitivity, Specificity and Predictive Accuracy of Radionuclide Cineangiography During Exercise in Patients with Coronary Artery Disease: Comparison with Exercise Electrocardiography , 1979, Circulation.

[6]  M. Brizendine,et al.  Effects of Maximal Exercise Stress on Left Ventricular Function in Patients with Coronary Artery Disease Using First Pass Radionuclide Angiocardiography: A Rapid, Noninvasive Technique for Determining Ejection Fraction and Segmental Wall Motion , 1979, Circulation.

[7]  G. E. Newman,et al.  Noninvasive radionuclide assessment of cardiac function in patients with peripheral vascular disease. , 1979, Surgery.

[8]  A. Gottschalk,et al.  Global and regional left ventricular response to bicycle exercise in coronary artery disease. Assessment by quantitative radionuclide angiocardiography. , 1979, The American journal of medicine.

[9]  R. Helfant,et al.  Detection of Coronary Heart Disease Using Radionuclide Determined Regional Ejection Fraction at Rest and During Handgrip Exercise: Correlation with Coronary Arteriography , 1978, Circulation.

[10]  G. E. Newman,et al.  Cardiac Function at Rest and During Exercise in Normals and in Patients with Coronary Heart Disease: Evaluation by Radionuclide Angiocardiography , 1978, Annals of surgery.

[11]  R. Marshall,et al.  Assessment of Cardiac Performance with Quantitative Radionuclide Angiocardiography: Sequential Left Ventricular Ejection Fraction, Normalized Left Ventricular Ejection Rate, and Regional Wall Motion , 1977, Circulation.

[12]  J. Colgan,et al.  Ultrastructure of the aging myocardium: a morphometric approach. , 1977, The American journal of anatomy.

[13]  R. Shephard,et al.  Maximum and submaximum exercise tests in men and women in the seventh, eighth, and ninth decades of life. , 1977, Journal of applied physiology: respiratory, environmental and exercise physiology.

[14]  P. B. Goldberg,et al.  Changes in the biochemistry of the rat heart with increasing age. , 1976, Experimental aging research.

[15]  E. Lakatta,et al.  Age changes in myocardial function and exercise response. , 1976, Progress in cardiovascular diseases.

[16]  E. Lakatta,et al.  Diminished Inotropic Response of Aged Myocardium to Catecholamines , 1975, Circulation research.

[17]  Å. Kilbom,et al.  Reduction in maximal oxygen uptake with age. , 1973, Journal of applied physiology.

[18]  R. Bruce,et al.  Longitudinal variations in maximal oxygen intake with age and activity. , 1972, Journal of applied physiology.

[19]  L. Solberg,et al.  Distribution of coronary and aortic atherosclerosis by geographic location, race, and sex. , 1968, Laboratory investigation; a journal of technical methods and pathology.

[20]  H Sandler,et al.  The use of single plane angiocardiograms for the calculation of left ventricular volume in man. , 1968, American heart journal.

[21]  A. Amery,et al.  Influence of Age on the Hemodynamic Response to Exercise , 1967, Circulation.

[22]  B JONSSON,et al.  CIRCULATION IN HEALTHY OLD MEN, STUDIED BY RIGHT HEART CATHETERIZATION AT REST AND DURING EXERCISE IN SUPINE AND SITTING POSITION. , 2009, Acta medica Scandinavica.

[23]  A. Wallace,et al.  Intrinsic effects of heart rate on left ventricular performance , 1963 .

[24]  Per-Olof Åstrand,et al.  Maximal heart rate during work in older men , 1959 .

[25]  Jesse E. Edwards,et al.  The Relationship of the Degree of Coronary Atherosclerosis with Age, in Men , 1950 .

[26]  A. Master,et al.  A SIMPLE EXERCISE TOLERANCE TEST FOR CIRCULATORY EFFICIENCY WITH STANDARD TABLES FOR NORMAL INDIVIDUALS , 1929 .