Neuropsychologic Functioning in Children with Autism: Further Evidence for Disordered Complex Information-Processing

A wide range of abilities was assessed in 56 high-functioning children with autism and 56 age- and IQ-matched controls. Stepwise discriminant analyses produced good group discrimination for sensory-perceptual, motor, complex language, and complex memory domains but lower agreement for the reasoning domain than previously obtained for adults. Group discrimination did not occur for attention, simple language, simple memory, and visuospatial domains. Findings provide additional support for a complex information-processing model for autism, previously based on adult data, demonstrating a pattern across domains of selective impairments on measures with high demands for integration of information and sparing when demands were low. Children as compared to adults with autism exhibited more prominent sensory-perceptual symptoms and less pronounced reasoning deficits reflecting brain maturation.

[1]  G. Dawson,et al.  Interventions to Facilitate Auditory, Visual, and Motor Integration in Autism: A Review of the Evidence , 2000, Journal of autism and developmental disorders.

[2]  M. Rutter,et al.  Autism and pervasive developmental disorders: Concepts and diagnostic issues , 1987, Journal of autism and developmental disorders.

[3]  B. Pennington,et al.  Intact and impaired memory functions in autism. , 1996, Child development.

[4]  Kevin J. Riggs,et al.  Motion processing in autism: evidence for a dorsal stream deficiency , 2000, Neuroreport.

[5]  G. Baranek Autism During Infancy: A Retrospective Video Analysis of Sensory-Motor and Social Behaviors at 9–12 Months of Age , 1999, Journal of autism and developmental disorders.

[6]  R. Schultz,et al.  Source Memory in Children With Autism Spectrum Disorders , 2005, Developmental neuropsychology.

[7]  Tom Benton,et al.  Eshkol-Wachman movement notation in diagnosis: the early detection of Asperger's syndrome. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[8]  W. Dunn,et al.  A comparison of the performance of children with and without autism on the Sensory Profile. , 1997, The American journal of occupational therapy : official publication of the American Occupational Therapy Association.

[9]  D. Zee,et al.  Deficits in the initiation of eye movements in the absence of a visual target in adolescents with high functioning autism , 2002, Neuropsychologia.

[10]  L. Mottron,et al.  A study of memory functioning in individuals with autism. , 2001, Journal of child psychology and psychiatry, and allied disciplines.

[11]  G. Dawson,et al.  Early social attention impairments in autism: social orienting, joint attention, and attention to distress. , 2004, Developmental psychology.

[12]  L. Klinger,et al.  Implicit and Explicit Memory in Autism: Is Autism an Amnesic Disorder? , 2000, Journal of autism and developmental disorders.

[13]  L. Koegel,et al.  Joint attention and children with autism: a review of the literature. , 2004, Mental retardation and developmental disabilities research reviews.

[14]  P. Malik On equivalence. , 2003, The Canadian journal of cardiology.

[15]  R. Woodcock Woodcock Reading Mastery Tests-Revised , 1987 .

[16]  T. Hammeke,et al.  Luria-Nebraska neuropsychological battery : forms I and II : manual , 1985 .

[17]  T. Kemper,et al.  NEUROANATOMICAL OBSERVATIONS OF THE BRAIN IN AUTISM , 2003 .

[18]  N. Minshew,et al.  Oculomotor abnormalities parallel cerebellar histopathology in autism , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[19]  N. Minshew,et al.  Abstract reasoning in autism: a dissociation between concept formation and concept identification. , 2002, Neuropsychology.

[20]  J. Faubert,et al.  Enhanced and diminished visuo-spatial information processing in autism depends on stimulus complexity. , 2005, Brain : a journal of neurology.

[21]  D. Bowler,et al.  Asperger's syndrome and memory: Similarity to autism but not amnesia , 1997, Neuropsychologia.

[22]  Beatrice de Gelder,et al.  Face processing in autistics: Evidence for a generalised deficit? , 1996 .

[23]  G. Dawson,et al.  Performance on Cambridge Neuropsychological Test Automated Battery Subtests Sensitive to Frontal Lobe Function in People with Autistic Disorder: Evidence from the Collaborative Programs of Excellence in Autism Network , 2004, Journal of autism and developmental disorders.

[24]  N. Minshew,et al.  Configural processing in autism and its relationship to face processing , 2006, Neuropsychologia.

[25]  J. Vroomen,et al.  Face recognition and lip-reading in autism , 1991 .

[26]  J. Rumsey,et al.  Neuropsychological findings in high-functioning men with infantile autism, residual state. , 1988, Journal of clinical and experimental neuropsychology.

[27]  David L. Strayer,et al.  Executive function abilities in autism and Tourette syndrome: an information processing approach. , 1994, Journal of child psychology and psychiatry, and allied disciplines.

[28]  E. Hill Evaluating the theory of executive dysfunction in autism , 2004 .

[29]  I. Rapin,et al.  Autistic children: diagnosis and clinical features. , 1991, Pediatrics.

[30]  B. Pennington,et al.  Executive functions and developmental psychopathology. , 1996, Journal of child psychology and psychiatry, and allied disciplines.

[31]  F. Volkmar,et al.  Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome. , 2000, Archives of general psychiatry.

[32]  Christopher F. Chabris,et al.  Early visual cortex organization in autism: an fMRI study , 2004, Neuroreport.

[33]  N. Minshew,et al.  Underdevelopment of the postural control system in autism , 2004, Neurology.

[34]  N. Minshew,et al.  The pattern of intact and impaired memory functions in autism. , 2001, Journal of child psychology and psychiatry, and allied disciplines.

[35]  D. Wechsler Wechsler Intelligence Scale for Children , 2020, Definitions.

[36]  N. Minshew,et al.  Neuropsychologic functioning in autism: Profile of a complex information processing disorder , 1997, Journal of the International Neuropsychological Society.

[37]  J. Faubert,et al.  Motion Perception in Autism: A Complex Issue , 2003, Journal of Cognitive Neuroscience.

[38]  J. Boucher Immediate free recall in early childhood autism: another point of behavioural similarity with the amnesic syndrome. , 1981, British journal of psychology.

[39]  B. Leventhal,et al.  The Autism Diagnostic Observation Schedule—Generic: A Standard Measure of Social and Communication Deficits Associated with the Spectrum of Autism , 2000, Journal of autism and developmental disorders.

[40]  A. Couteur,et al.  Autism diagnostic interview: A standardized investigator-based instrument , 1989, Journal of autism and developmental disorders.

[41]  Geraldine Dawson,et al.  Event-related brain potentials reveal anomalies in temporal processing of faces in autism spectrum disorder. , 2004, Journal of child psychology and psychiatry, and allied disciplines.

[42]  J. Nici,et al.  A Compendium of Neuropsychological Tests, 2nd ed , 2000 .

[43]  J. Bachevalier Medial temporal lobe structures and autism: A review of clinical and experimental findings , 1994, Neuropsychologia.

[44]  C. Reynolds,et al.  Wechsler memory scale-revised , 1988 .

[45]  N. Butters,et al.  Memory deficits in chronic alcoholics: continuities between the "intact" alcoholic and the alcoholic Korsakoff patient. , 1980, Advances in experimental medicine and biology.

[46]  Marcel Adam Just,et al.  Functional connectivity in an fMRI working memory task in high-functioning autism , 2005, NeuroImage.

[47]  N. Minshew,et al.  New perspectives in autism, Part I: The clinical spectrum of autism. , 1988, Current problems in pediatrics.

[48]  B. Pennington,et al.  Spatial Cognition in Autism Spectrum Disorders: Superior, Impaired, or Just Intact? , 2005, Journal of autism and developmental disorders.

[49]  N. Minshew,et al.  Autism as a selective disorder of complex information processing and underdevelopment of neocortical systems , 2002, Molecular Psychiatry.

[50]  J. R. Landis,et al.  The measurement of observer agreement for categorical data. , 1977, Biometrics.

[51]  D. Delis,et al.  The California verbal learning test , 2016 .

[52]  M. Just,et al.  Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity. , 2004, Brain : a journal of neurology.

[53]  M. Lezak Neuropsychological assessment, 3rd ed. , 1995 .

[54]  C. Frith,et al.  Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. , 2002, Brain : a journal of neurology.

[55]  G. Dawson,et al.  Brain structural abnormalities in young children with autism spectrum disorder , 2002, Neurology.

[56]  J. Fletcher Memory for verbal and nonverbal stimuli in learning disability subgroups: analysis by selective reminding. , 1985, Journal of experimental child psychology.

[57]  J. Piven,et al.  Magnetic resonance imaging and head circumference study of brain size in autism: birth through age 2 years. , 2005, Archives of general psychiatry.

[58]  S. Baron-Cohen,et al.  Does the autistic child have a “theory of mind” ? , 1985, Cognition.

[59]  Geraldine Dawson,et al.  Attention and the socioemotional impairments of individuals with autism , 1989 .

[60]  Nancy J. Minshew,et al.  Is autism an amnesic disorder? Evidence from the California Verbal Learning Test. , 1993 .

[61]  N. Minshew,et al.  The cognitive and neural basis of autism: A disorder of complex information processing and dysfunction of neocortical systems , 2000 .

[62]  N. Minshew,et al.  Sensory Sensitivities and Performance on Sensory Perceptual Tasks in High-functioning Individuals with Autism , 2008, Journal of autism and developmental disorders.

[63]  E. Ornitz The functional neuroanatomy of infantile autism. , 1983, The International journal of neuroscience.

[64]  M. Just,et al.  Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometry. , 2007, Cerebral cortex.

[65]  U. Frith,et al.  An islet of ability in autistic children: a research note. , 1983, Journal of child psychology and psychiatry, and allied disciplines.

[66]  Robert A. Bornstein,et al.  The Wechsler Memory Scale—Revised , 1990 .

[67]  G. S. Wilkinson,et al.  Wide Range Achievement Test 4 , 2016 .

[68]  M. A. Merrill,et al.  Stanford-Binet Intelligence Scale , 1972 .

[69]  A. Leslie The theory of mind impairment in autism: Evidence for a modular mechanism of development? , 1991 .

[70]  M. Schlossberg The Halstead-Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation. , 1986 .

[71]  R. Heaton Wisconsin Card Sorting Test manual , 1993 .

[72]  R. Joseph,et al.  Holistic and part-based face recognition in children with autism. , 2003, Journal of child psychology and psychiatry, and allied disciplines.

[73]  K. Wolstencroft The Wide Range Assessment of Memory and Learning, W. Adams & D. Sheslow (1990). Wilmington , 1996, Australian Journal of Guidance and Counselling.

[74]  S. Hepburn,et al.  Imitation performance in toddlers with autism and those with other developmental disorders. , 2003, Journal of child psychology and psychiatry, and allied disciplines.

[75]  S. J. Press,et al.  Choosing between Logistic Regression and Discriminant Analysis , 1978 .

[76]  F. Volkmar,et al.  A Normed Study of Face Recognition in Autism and Related Disorders , 1999, Journal of autism and developmental disorders.

[77]  Eric Courchesne,et al.  Outcome classification of preschool children with autism spectrum disorders using MRI brain measures. , 2004, Journal of the American Academy of Child and Adolescent Psychiatry.

[78]  Giacomo Mauro DAriano Guidelines for presenting multivariate statistical analysis in Rehabilitation Psychology. , 1992 .

[79]  S. Rogers,et al.  Annotation: what do we know about sensory dysfunction in autism? A critical review of the empirical evidence. , 2005, Journal of child psychology and psychiatry, and allied disciplines.

[80]  N. Minshew,et al.  Autism as a disorder of complex information processing , 1998 .

[81]  Herbert Roeyers,et al.  How specific are executive functioning deficits in attention deficit hyperactivity disorder and autism? , 2004, Journal of child psychology and psychiatry, and allied disciplines.

[82]  Natacha Akshoomoff,et al.  Executive Functions in Autism and Asperger's Disorder: Flexibility, Fluency, and Inhibition , 2005, Developmental neuropsychology.

[83]  Ruth A. Carper,et al.  Unusual brain growth patterns in early life in patients with autistic disorder , 2001, Neurology.

[84]  A. Couteur,et al.  Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders , 1994, Journal of autism and developmental disorders.

[85]  S. Hepburn,et al.  Parent Reports of Sensory Symptoms in Toddlers with Autism and Those with Other Developmental Disorders , 2003, Journal of autism and developmental disorders.

[86]  J. Brian,et al.  Behavioral manifestations of autism in the first year of life , 2005, International Journal of Developmental Neuroscience.

[87]  G. Baranek,et al.  Sensory Defensiveness in Persons with Developmental Disabilities , 1997 .

[88]  J Townsend,et al.  Impairment in shifting attention in autistic and cerebellar patients. , 1994, Behavioral neuroscience.