Tracer Kinetic Modeling in Nuclear Medicine: Theory and Applications

This chapter has presented the basic principles and clinical and research applications of the kinetic modeling approach, which can be applied to various dynamic data acquired by planar scintigraphy, SPECT or PET. Two main difficulties can arise when selecting a particular compartmental model: when the number of identifiable components is less than the chosen model (e.g. high noise) or more than the chosen model (e.g. heterogeneity). Different strategies have been suggested to tackle these problems.

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