Degradation of Soluble Amyloid β-Peptides 1–40, 1–42, and the Dutch Variant 1–40Q by Insulin Degrading Enzyme from Alzheimer Disease and Control Brains

[1]  B. Bogerts,et al.  Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques , 1999, Neuroscience Letters.

[2]  L. Morelli,et al.  Internalization and resistance to degradation of Alzheimer's Aβ1–42 at nanomolar concentrations in THP-1 human monocytic cell line , 1999, Neuroscience Letters.

[3]  L. Hersh,et al.  Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation* , 1998, The Journal of Biological Chemistry.

[4]  W. Duckworth,et al.  Insulin degradation: progress and potential. , 1998, Endocrine reviews.

[5]  Claudio Soto,et al.  β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy , 1998, Nature Medicine.

[6]  I. Kurochkin Amyloidogenic determinant as a substrate recognition motif of insulin‐degrading enzyme , 1998, FEBS letters.

[7]  T. Saido Alzheimer’s Disease as Proteolytic Disorders: Anabolism and Catabolism of β-Amyloid , 1998, Neurobiology of Aging.

[8]  D. Selkoe,et al.  Degradation of Amyloid β-Protein by a Metalloprotease Secreted by Microglia and Other Neural and Non-neural Cells* , 1997, The Journal of Biological Chemistry.

[9]  Michael J. Cullen,et al.  Matrix Metalloproteinase-9 (MMP-9) Is Synthesized in Neurons of the Human Hippocampus and Is Capable of Degrading the Amyloid-β Peptide (1–40) , 1996, The Journal of Neuroscience.

[10]  J. Lowe,et al.  Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome , 1996, Neuroscience Letters.

[11]  L. Hersh,et al.  Identification of γ-Endorphin-Generating Enzyme as Insulin-Degrading Enzyme† , 1996 .

[12]  D. Selkoe,et al.  Amyloid β-Protein and the Genetics of Alzheimer's Disease* , 1996, The Journal of Biological Chemistry.

[13]  D. Selkoe,et al.  Degradation of Amyloid -Protein by a Serine Protease--Macroglobulin Complex (*) , 1996, The Journal of Biological Chemistry.

[14]  M. Ball,et al.  Water-soluble A(N-40, N-42) Oligomers in Normal and Alzheimer Disease Brains (*) , 1996, The Journal of Biological Chemistry.

[15]  S. Howell,et al.  Neutral endopeptidase can hydrolyze β-amyloid(1–40) but shows no effect on β-amyloid precursor protein metabolism , 1995, Peptides.

[16]  T. Wisniewski,et al.  Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E. , 1995, The Biochemical journal.

[17]  Jinhe Li,et al.  Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system , 1995, Neuron.

[18]  C. Soto,et al.  The -Helical to -Strand Transition in the Amino-terminal Fragment of the Amyloid -Peptide Modulates Amyloid Formation * , 1995, The Journal of Biological Chemistry.

[19]  D. Quon,et al.  -Amyloid Peptide Produced in Vitro Is Degraded by Proteinases Released by Cultured Cells (*) , 1995, The Journal of Biological Chemistry.

[20]  M. Ball,et al.  Proteolysis of Aβ Peptide from Alzheimer Disease Brain by Gelatinase A , 1994 .

[21]  L. Tjernberg,et al.  The Alzheimer A beta peptide develops protease resistance in association with its polymerization into fibrils. , 1994, The Journal of biological chemistry.

[22]  F. S. French,et al.  Androgen and glucocorticoid receptors interact with insulin degrading enzyme. , 1994, The Journal of biological chemistry.

[23]  T. Holzman,et al.  Cleavage at the amino and carboxyl termini of Alzheimer's amyloid-beta by cathepsin D. , 1994, The Journal of biological chemistry.

[24]  I. Kurochkin,et al.  Alzheimer's β‐amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme , 1994, FEBS letters.

[25]  P. Lansbury,et al.  The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. , 1993, Biochemistry.

[26]  Khadija Iqbal,et al.  Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease. , 1993, Archives of biochemistry and biophysics.

[27]  A. Montag,et al.  Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues. , 1993, Endocrinology.

[28]  D. Selkoe,et al.  Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids , 1992, Nature.

[29]  J. Mcdermott,et al.  Human brain peptidase activity with the specificity to generate the N-terminus of the Alzheimer beta-amyloid protein from its precursor. , 1992, Biochemical and biophysical research communications.

[30]  D. Richter,et al.  Atrial natriuretic peptide (ANP) is a high-affinity substrate for rat insulin-degrading enzyme. , 1991, European journal of biochemistry.

[31]  M. Rosner,et al.  Regulation of insulin, epidermal growth factor, and transforming growth factor-alpha levels by growth factor-degrading enzymes. , 1991, Endocrinology.

[32]  M. Kasuga,et al.  Natural regulatory mechanisms of insulin degradation by insulin degrading enzyme. , 1990, Biochemical and biophysical research communications.

[33]  I. Lieberburg,et al.  Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. , 1990, Science.

[34]  M. Rosner,et al.  An evolutionarily conserved enzyme degrades transforming growth factor- alpha as well as insulin , 1989, The Journal of cell biology.

[35]  David M. A. Mann,et al.  Cerebral amyloidosis, ageing and Alzheimer's disease; A contribution from studies on Down's syndrome , 1989, Neurobiology of Aging.

[36]  C. Kayalar,et al.  Metalloendoprotease inhibitors which block the differentiation of L6 myoblasts inhibit insulin degradation by the endogenous insulin-degrading enzyme. , 1989, The Journal of biological chemistry.

[37]  V. Fried,et al.  Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III. , 1988, Science.

[38]  W. Duckworth Insulin degradation: mechanisms, products, and significance. , 1988, Endocrine reviews.

[39]  H. Schägger,et al.  Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. , 1987, Analytical biochemistry.

[40]  R. Roth,et al.  In vivo association of [125I]-insulin with a cytosolic insulin-degrading enzyme: detection by covalent cross-linking and immunoprecipitation with a monoclonal antibody. , 1987, Endocrinology.

[41]  R. Roth,et al.  Purification and Characterization of Insulin-Degrading Enzyme From Human Erythrocytes , 1986, Diabetes.

[42]  R. Roth,et al.  Covalent linkage of 125I-insulin to a cytosolic insulin-degrading enzyme. , 1985, The Journal of biological chemistry.

[43]  A. Turner,et al.  The metabolism of neuropeptides. The hydrolysis of peptides, including enkephalins, tachykinins and their analogues, by endopeptidase-24.11. , 1984, The Biochemical journal.

[44]  E. Almira,et al.  Inhibition of insulin degradation by insulin-like growth factors. , 1983, Endocrinology.

[45]  W. Duckworth,et al.  The Effect of Age on Insulin-degrading Activity in Rat Tissue , 1979, Diabetes.

[46]  A. Turner,et al.  The metabolism of neuropeptides , 2005 .

[47]  J. Mcdermott,et al.  Degradation of Alzheimer's ß-Amyloid Protein by Human and Rat Brain Peptidases: Involvement of Insulin-Degrading Enzyme , 2004, Neurochemical Research.

[48]  W. Duckworth,et al.  Regulation of multicatalytic enzyme activity by insulin and the insulin-degrading enzyme. , 1998, Endocrinology.

[49]  T. Saido Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid. , 1998, Neurobiology of aging.

[50]  L. Hersh,et al.  Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme. , 1996, Biochemistry.

[51]  D. Selkoe,et al.  Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. , 1994, Annual review of cell biology.