Split-protein systems: beyond binary protein-protein interactions.

[1]  I. Ghosh,et al.  A Comprehensive Panel of Turn‐On Caspase Biosensors for Investigating Caspase Specificity and Caspase Activation Pathways , 2011, Chembiochem : a European journal of chemical biology.

[2]  A. Badran,et al.  Evaluating the global CpG methylation status of native DNA utilizing a bipartite split-luciferase sensor. , 2011, Analytical chemistry.

[3]  A. Badran,et al.  Turn-on DNA damage sensors for the direct detection of 8-oxoguanine and photoproducts in native DNA. , 2011, Journal of the American Chemical Society.

[4]  I. Ghosh,et al.  A turn-on split-luciferase sensor for the direct detection of poly(ADP-ribose) as a marker for DNA repair and cell death. , 2011, Chemical communications.

[5]  M. Belfort,et al.  Protease Activation of Split Green Fluorescent Protein , 2010, Chembiochem : a European journal of chemical biology.

[6]  S. Lindman,et al.  In vivo protein stabilization based on fragment complementation and a split GFP system , 2010, Proceedings of the National Academy of Sciences.

[7]  S. Joy,et al.  Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2. , 2010, Chemical communications.

[8]  R. Wyatt,et al.  A general approach for receptor and antibody-targeted detection of native proteins utilizing split-luciferase reassembly. , 2010, ACS chemical biology.

[9]  A. Badran,et al.  Toward a general approach for RNA-templated hierarchical assembly of split-proteins. , 2010, Journal of the American Chemical Society.

[10]  Sami Mahrus,et al.  Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease , 2010, Cell.

[11]  I. Ghosh,et al.  A coiled-coil enabled split-luciferase three-hybrid system: applied toward profiling inhibitors of protein kinases. , 2010, Journal of the American Chemical Society.

[12]  B. White,et al.  Chemically controlled protein assembly: techniques and applications. , 2010, Chemical reviews.

[13]  Aitziber L Cortajarena,et al.  Screening Libraries to Identify Proteins with Desired Binding Activities Using a Split-gfp Reassembly Assay , 2022 .

[14]  S. Gambhir,et al.  A molecularly engineered split reporter for imaging protein-protein interactions with positron emission tomography , 2010, Nature Medicine.

[15]  D. Hilvert,et al.  Design, selection, and characterization of a split chorismate mutase , 2010, Protein science : a publication of the Protein Society.

[16]  Stephanie J. Culler,et al.  In vivo fluorescent detection of Fe-S clusters coordinated by human GRX2. , 2009, Chemistry & biology.

[17]  I. Ghosh,et al.  An autoinhibited coiled-coil design strategy for split-protein protease sensors. , 2009, Journal of the American Chemical Society.

[18]  S. Ikeda,et al.  Rapid Modification of Proteins Using a Rapamycin-Inducible Tobacco Etch Virus Protease System , 2009, PloS one.

[19]  N. Ueno,et al.  High-Sensitivity Real-Time Imaging of Dual Protein-Protein Interactions in Living Subjects Using Multicolor Luciferases , 2009, PloS one.

[20]  N. Johnsson,et al.  Split‐Ubiquitin and the Split‐Protein Sensors: Chessman for the Endgame , 2008, Chembiochem : a European journal of chemical biology.

[21]  K. Kudo,et al.  Supramolecular control of split-GFP reassembly by conjugation of beta-cyclodextrin and coumarin units. , 2008, Journal of the American Chemical Society.

[22]  H. Ueda,et al.  Covalent split protein fragment-DNA hybrids generated through N-terminus-specific modification of proteins by oligonucleotides. , 2008, Organic & biomolecular chemistry.

[23]  Hyeong Jun An,et al.  Estimating the size of the human interactome , 2008, Proceedings of the National Academy of Sciences.

[24]  Indraneel Ghosh,et al.  A general and rapid cell-free approach for the interrogation of protein-protein, protein-DNA, and protein-RNA interactions and their antagonists utilizing split-protein reporters. , 2008, Journal of the American Chemical Society.

[25]  Y. Shyu,et al.  Visualization of AP-1–NF-κB ternary complexes in living cells by using a BiFC-based FRET , 2008, Proceedings of the National Academy of Sciences.

[26]  S. Lemieux,et al.  Functional Calcitonin Gene-related Peptide Receptors Are Formed by the Asymmetric Assembly of a Calcitonin Receptor-like Receptor Homo-oligomer and a Monomer of Receptor Activity-modifying Protein-1* , 2007, Journal of Biological Chemistry.

[27]  K. Nakai,et al.  [Controlling signal transduction with synthetic ligands]. , 2007, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

[28]  D. Segal,et al.  Split β-lactamase sensor for the sequence-specific detection of DNA methylation , 2007 .

[29]  Tom W Muir,et al.  Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt , 2007, Proceedings of the National Academy of Sciences.

[30]  Stephen W. Michnick,et al.  Universal strategies in research and drug discovery based on protein-fragment complementation assays , 2007, Nature Reviews Drug Discovery.

[31]  Yoshio Umezawa,et al.  Imaging dynamics of endogenous mitochondrial RNA in single living cells , 2007, Nature Methods.

[32]  S. Michnick,et al.  A highly sensitive protein-protein interaction assay based on Gaussia luciferase , 2006, Nature Methods.

[33]  M. Robitaille,et al.  Seven Transmembrane Receptor Core Signaling Complexes Are Assembled Prior to Plasma Membrane Trafficking* , 2006, Journal of Biological Chemistry.

[34]  Tobias M. Fischer,et al.  Monitoring regulated protein-protein interactions using split TEV , 2006, Nature Methods.

[35]  J. Lamerdin,et al.  Identifying off-target effects and hidden phenotypes of drugs in human cells , 2006, Nature chemical biology.

[36]  D. Segal,et al.  Site-specific detection of DNA methylation utilizing mCpG-SEER. , 2006, Journal of the American Chemical Society.

[37]  S. Schlenker,et al.  A Small‐Molecule–Protein Interaction System with Split‐Ubiquitin as Sensor , 2006, Chembiochem : a European journal of chemical biology.

[38]  A. Plückthun,et al.  Rapid selection of specific MAP kinase-binders from designed ankyrin repeat protein libraries. , 2006, Protein engineering, design & selection : PEDS.

[39]  C. Cantor,et al.  Fast complementation of split fluorescent protein triggered by DNA hybridization , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[40]  S. Michnick,et al.  Massive sequence perturbation of a small protein. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[41]  David J Segal,et al.  DNA sequence-enabled reassembly of the green fluorescent protein. , 2005, Journal of the American Chemical Society.

[42]  S. Michnick,et al.  Capturing protein interactions in the secretory pathway of living cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[43]  Thomas J Magliery,et al.  Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism. , 2005, Journal of the American Chemical Society.

[44]  Chris M. Brown,et al.  Visualization of RNA–protein interactions in living cells: FMRP and IMP1 interact on mRNAs , 2004, The EMBO journal.

[45]  H. Piwnica-Worms,et al.  Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[46]  Chang‐Deng Hu,et al.  Simultaneous visualization of multiple protein interactions in living cells using multicolor fluorescence complementation analysis , 2003, Nature Biotechnology.

[47]  S S Gambhir,et al.  Monitoring protein-protein interactions using split synthetic renilla luciferase protein-fragment-assisted complementation. , 2003, Analytical chemistry.

[48]  A. Galarneau,et al.  β-Lactamase protein fragment complementation assays as in vivo and in vitro sensors of protein–protein interactions , 2002, Nature Biotechnology.

[49]  A. Plückthun,et al.  Fast selection of antibodies without antigen purification: adaptation of the protein fragment complementation assay to select antigen-antibody pairs. , 2001, Journal of molecular biology.

[50]  L. Regan,et al.  Antiparallel Leucine Zipper-Directed Protein Reassembly: Application to the Green Fluorescent Protein , 2000 .

[51]  J. H. Shim,et al.  Combinatorial protein engineering by incremental truncation. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[52]  S. Michnick,et al.  Oligomerization domain-directed reassembly of active dihydrofolate reductase from rationally designed fragments. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[53]  E J Licitra,et al.  A three-hybrid system for detecting small ligand-protein receptor interactions. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[54]  A. Varshavsky,et al.  Split ubiquitin as a sensor of protein interactions in vivo. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[55]  S. Fields,et al.  A novel genetic system to detect protein–protein interactions , 1989, Nature.

[56]  J. Monod,et al.  Characterization by in vitro complementation of a peptide corresponding to an operator-proximal segment of the beta-galactosidase structural gene of Escherichia coli. , 1967, Journal of molecular biology.

[57]  F. Richards ON THE ENZYMIC ACTIVITY OF SUBTILISIN-MODIFIED RIBONUCLEASE. , 1958, Proceedings of the National Academy of Sciences of the United States of America.

[58]  D. Segal,et al.  Split beta-lactamase sensor for the sequence-specific detection of DNA methylation. , 2007, Analytical chemistry.

[59]  Roger Y. Tsien,et al.  Creating new fluorescent probes for cell biology , 2003, Nature Reviews Molecular Cell Biology.

[60]  Stephen W Michnick,et al.  Beta-lactamase protein fragment complementation assays as in vivo and in vitro sensors of protein protein interactions. , 2002, Nature biotechnology.

[61]  Katja M. Arndt,et al.  An in vivo library-versus-library selection of optimized protein–protein interactions , 1999, Nature Biotechnology.