The role of small GTPases of the Rho/Rac family in TGF‐β‐induced EMT and cell motility in cancer
暂无分享,去创建一个
[1] Maria João M Bugalho,et al. RAC1b overexpression stimulates proliferation and NF-kB-mediated anti-apoptotic signaling in thyroid cancer cells , 2017, PloS one.
[2] P. Fisher,et al. MDA-9/Syntenin (SDCBP) modulates small GTPases RhoA and Cdc42 via transforming growth factor β1 to enhance epithelial-mesenchymal transition in breast cancer , 2016, Oncotarget.
[3] H. Kalthoff,et al. Negative control of TRAIL-R1 signaling by transforming growth factor β1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1. , 2016, Cellular signalling.
[4] J. West-Mays,et al. RhoA/ROCK Signaling Regulates TGFβ-Induced Epithelial-Mesenchymal Transition of Lens Epithelial Cells through MRTF-A , 2016, Molecular medicine.
[5] H. Aburatani,et al. Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional program , 2016, Science Signaling.
[6] C. Heldin,et al. Signaling Receptors for TGF-β Family Members. , 2016, Cold Spring Harbor perspectives in biology.
[7] C. Heldin,et al. Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition , 2016, Journal of clinical medicine.
[8] Yi Lu,et al. Reciprocal activation between MMP-8 and TGF-β1 stimulates EMT and malignant progression of hepatocellular carcinoma. , 2016, Cancer letters.
[9] C. Iacobuzio-Donahue,et al. Molecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy , 2016, Expert opinion on therapeutic targets.
[10] D. Brann,et al. Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-β1/ROCK1 pathway in silicosis in rat. , 2016, Toxicology and applied pharmacology.
[11] Hong Wang,et al. Rac1b enhances cell survival through activation of the JNK2/c-JUN/Cyclin-D1 and AKT2/MCL1 pathways , 2016, Oncotarget.
[12] N. Bhowmick,et al. Role of EMT in Metastasis and Therapy Resistance , 2016, Journal of clinical medicine.
[13] M. Moyer,et al. Expression of tumor-related Rac1b antagonizes B-Raf-induced senescence in colorectal cells. , 2015, Cancer letters.
[14] X. Guan,et al. Cancer metastases: challenges and opportunities , 2015, Acta pharmaceutica Sinica. B.
[15] Ying Yan,et al. Rac1 GTPase in pancreatic cancer , 2015, Aging.
[16] Yi Zheng,et al. Approaches of targeting Rho GTPases in cancer drug discovery , 2015, Expert opinion on drug discovery.
[17] P. R. Somanath,et al. P21 activated kinase-1 mediates transforming growth factor β1-induced prostate cancer cell epithelial to mesenchymal transition. , 2015, Biochimica et biophysica acta.
[18] M. Saitoh. Epithelial–mesenchymal transition is regulated at post-transcriptional levels by transforming growth factor-β signaling during tumor progression , 2015, Cancer science.
[19] Ying Jin,et al. TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis , 2015, Genes & development.
[20] H. Bien,et al. PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice. , 2014, Gastroenterology.
[21] Klaus Pantel,et al. Biology, detection, and clinical implications of circulating tumor cells , 2014, EMBO molecular medicine.
[22] Lukas D. Osborne,et al. TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion , 2014, Molecular biology of the cell.
[23] Hongli Lin,et al. Rho/Rock cross-talks with transforming growth factor-β/Smad pathway participates in lung fibroblast-myofibroblast differentiation. , 2014, Biomedical reports.
[24] A. Jochemsen,et al. Wild-type p53 inhibits pro-invasive properties of TGF-β3 in breast cancer, in part through regulation of EPHB2, a new TGF-β target gene , 2014, Breast Cancer Research and Treatment.
[25] K. Miyazawa,et al. Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) Suppress Cancer Cell Motility via Different Mechanisms* , 2014, The Journal of Biological Chemistry.
[26] K. Griendling,et al. RhoA/Rho kinase mediates TGF-β1-induced kidney myofibroblast activation through Poldip2/Nox4-derived reactive oxygen species. , 2014, American journal of physiology. Renal physiology.
[27] D. Hommes,et al. Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK. , 2014, Gastroenterology.
[28] Wen-feng Gou,et al. The role of RhoC in epithelial-to-mesenchymal transition of ovarian carcinoma cells , 2014, BMC Cancer.
[29] D. Gomez,et al. Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines , 2014, Anti-cancer agents in medicinal chemistry.
[30] Shui-juan Zhang,et al. Cigarette smoke-induced alveolar epithelial-mesenchymal transition is mediated by Rac1 activation. , 2014, Biochimica et biophysica acta.
[31] D. Radisky,et al. Tumor Cell–Derived MMP3 Orchestrates Rac1b and Tissue Alterations That Promote Pancreatic Adenocarcinoma , 2014, Molecular Cancer Research.
[32] T. Leto,et al. Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells , 2014, British Journal of Cancer.
[33] Samy Lamouille,et al. Molecular mechanisms of epithelial–mesenchymal transition , 2014, Nature Reviews Molecular Cell Biology.
[34] T. Morita,et al. RPEL Proteins Are the Molecular Targets for CCG-1423, an Inhibitor of Rho Signaling , 2014, PloS one.
[35] K. Burridge,et al. The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration , 2014, Small GTPases.
[36] R. Neubig,et al. Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-&bgr;–Induced Fibrogenesis in Human Colonic Myofibroblasts , 2014, Inflammatory bowel diseases.
[37] H. Lehnert,et al. Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling , 2013, Oncotarget.
[38] M. Moyer,et al. Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells , 2013, RNA.
[39] A. Ridley,et al. Crossing the endothelial barrier during metastasis , 2013, Nature Reviews Cancer.
[40] Jae-Bong Park,et al. IκB Kinase γ/Nuclear Factor-κB-Essential Modulator (IKKγ/NEMO) Facilitates RhoA GTPase Activation, which, in Turn, Activates Rho-associated Kinase (ROCK) to Phosphorylate IKKβ in Response to Transforming Growth Factor (TGF)-β1* , 2013, The Journal of Biological Chemistry.
[41] Wai Leong Tam,et al. The epigenetics of epithelial-mesenchymal plasticity in cancer , 2013, Nature Medicine.
[42] D. Radisky,et al. Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells. , 2013, Differentiation; research in biological diversity.
[43] Pengcheng Zhu,et al. Loss of TAK1 increases cell traction force in a ROS-dependent manner to drive epithelial–mesenchymal transition of cancer cells , 2013, Cell Death and Disease.
[44] T. Lucas,et al. A Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice , 2013, PloS one.
[45] H. Zhang,et al. TGF-β1 induces the dissolution of tight junctions in human renal proximal tubular cells: role of the RhoA/ROCK signaling pathway. , 2013, International journal of molecular medicine.
[46] J. Alan,et al. Mutationally activated Rho GTPases in cancer , 2013, Small GTPases.
[47] Q. Gao,et al. Fasudil inhibits epithelial-myofibroblast transdifferentiation of human renal tubular epithelial HK-2 cells induced by high glucose. , 2013, Chemical & pharmaceutical bulletin.
[48] Yibin Kang,et al. Tumor cell dissemination: emerging biological insights from animal models and cancer patients. , 2013, Cancer cell.
[49] D. Radisky,et al. Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial–mesenchymal transition , 2012, Molecular biology of the cell.
[50] Ying Sun,et al. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. , 2012, Cancer research.
[51] M. Goumans,et al. MicroRNA-155 functions as a negative regulator of RhoA signaling in TGF-β-induced endothelial to mesenchymal transition. , 2012, MicroRNA.
[52] R. Jain,et al. TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma , 2012, Proceedings of the National Academy of Sciences.
[53] J. Massagué. TGFβ signalling in context , 2012, Nature Reviews Molecular Cell Biology.
[54] Ashley C. Brown,et al. Directing epithelial to mesenchymal transition through engineered microenvironments displaying orthogonal adhesive and mechanical cues. , 2012, Journal of biomedical materials research. Part A.
[55] S. Akunuru,et al. Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity , 2012, Cell Death and Disease.
[56] C. Turner,et al. Hic-5 promotes invadopodia formation and invasion during TGF-b–induced epithelial–mesenchymal transition , 2012 .
[57] C. Turner,et al. Hic-5 promotes invadopodia formation and invasion during TGF-β–induced epithelial–mesenchymal transition , 2012, The Journal of cell biology.
[58] Chi-Hung Huang,et al. RAC1 activation mediates Twist1-induced cancer cell migration , 2012, Nature Cell Biology.
[59] L. Cubano,et al. Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase* , 2012, The Journal of Biological Chemistry.
[60] Yi Zheng,et al. Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. , 2012, Chemistry & biology.
[61] S. Licciulli,et al. The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis , 2012, Oncogene.
[62] Kevin M. Curtis,et al. Rac1b regulates NT3-stimulated Mek-Erk signaling, directing marrow-isolated adult multilineage inducible (MIAMI) cells toward an early neuronal phenotype , 2012, Molecular and Cellular Neuroscience.
[63] Hiroshi I. Suzuki,et al. TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A. , 2012, Journal of biochemistry.
[64] H. Oettle,et al. Transforming growth factor beta in pancreatic cancer. , 2011, Current pharmaceutical biotechnology.
[65] B. Bapat,et al. Rac1b recruits Dishevelled and β-catenin to Wnt target gene promoters independent of Wnt3A stimulation. , 2011, International journal of oncology.
[66] S. Shirasawa,et al. BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study , 2011, Molecular Cancer.
[67] P. Mazur,et al. Early requirement of Rac1 in a mouse model of pancreatic cancer. , 2011, Gastroenterology.
[68] H. Lehnert,et al. Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1 , 2011, Molecular Cancer.
[69] R. Trembath,et al. CdGAP is required for transforming growth factor β- and Neu/ErbB-2-induced breast cancer cell motility and invasion , 2011, Oncogene.
[70] S. Sebens,et al. Differential roles of Src in transforming growth factor-ß regulation of growth arrest, epithelial-to-mesenchymal transition and cell migration in pancreatic ductal adenocarcinoma cells. , 2011, International journal of oncology.
[71] W. Jiang,et al. Growth and differentiation factor 9 (GDF-9) induces epithelial–mesenchymal transition in prostate cancer cells , 2011, Molecular and Cellular Biochemistry.
[72] Yi Zheng,et al. Rac1 Targeting Suppresses Human Non-Small Cell Lung Adenocarcinoma Cancer Stem Cell Activity , 2011, PloS one.
[73] Y. Ching,et al. Id‐1 induces cell invasiveness in immortalized epithelial cells by regulating cadherin switching and Rho GTPases , 2011, Journal of cellular biochemistry.
[74] M. Petz,et al. The crosstalk of RAS with the TGF-β family during carcinoma progression and its implications for targeted cancer therapy. , 2010, Current cancer drug targets.
[75] C. Vlaar,et al. Novel inhibitors of Rac1 in metastatic breast cancer. , 2010, Puerto Rico health sciences journal.
[76] D. Bar-Sagi,et al. Perturbation of cytoskeleton dynamics by the opposing effects of Rac1 and Rac1b , 2010, Small GTPases.
[77] Brian J. Smith,et al. ROLE OF RAC-1 DEPENDENT NADPH OXIDASE IN THE GROWTH OF PANCREATIC CANCER , 2010, Cancer Gene Therapy.
[78] C. Joo,et al. Smad3 Regulates Rho Signaling via NET1 in the Transforming Growth Factor-β-induced Epithelial-Mesenchymal Transition of Human Retinal Pigment Epithelial Cells* , 2010, The Journal of Biological Chemistry.
[79] J. Santibañez,et al. Rac1 modulates TGF‐β1‐mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes , 2010, FEBS letters.
[80] H. Ford,et al. Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression , 2010, Journal of Mammary Gland Biology and Neoplasia.
[81] N. Tobar,et al. ROS-NFκΒ mediates TGF-β1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion , 2010, Molecular and Cellular Biochemistry.
[82] B. Bryan,et al. Pharmacological inhibition of Rho-kinase signaling with Y-27632 blocks melanoma tumor growth. , 2010, Oncology reports.
[83] J. Mertz,et al. Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathway , 2009, BMC Cell Biology.
[84] D. Potter. Faculty Opinions recommendation of Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. , 2009 .
[85] K. Miyazono. Transforming growth factor-β signaling in epithelial-mesenchymal transition and progression of cancer , 2009, Proceedings of the Japan Academy. Series B, Physical and biological sciences.
[86] B. Hendry,et al. Rho isoforms have distinct and specific functions in the process of epithelial to mesenchymal transition in renal proximal tubular cells. , 2009, Cellular signalling.
[87] Robert A. Weinberg,et al. The basics of epithelial-mesenchymal transition. , 2009, The Journal of clinical investigation.
[88] E. Sahai,et al. Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement , 2008, Cell.
[89] G. Parmigiani,et al. Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses , 2008, Science.
[90] P. Jordan,et al. Increased Rac1b Expression Sustains Colorectal Tumor Cell Survival , 2008, Molecular Cancer Research.
[91] C. Der,et al. Specificity and Mechanism of Action of EHT 1864, a Novel Small Molecule Inhibitor of Rac Family Small GTPases* , 2007, Journal of Biological Chemistry.
[92] H. Cho,et al. Rho activation is required for transforming growth factor‐β‐induced epithelial‐mesenchymal transition in lens epithelial cells , 2007, Cell biology international.
[93] Richard R. Neubig,et al. CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling , 2007, Molecular Cancer Therapeutics.
[94] A. Menke,et al. Smad4-Independent TGF-β Signaling in Tumor Cell Migration , 2007, Cells Tissues Organs.
[95] B. Bapat,et al. Activation of tumor-specific splice variant Rac1b by dishevelled promotes canonical Wnt signaling and decreased adhesion of colorectal cancer cells. , 2007, Cancer research.
[96] Wen-Sheng Wu. The signaling mechanism of ROS in tumor progression , 2007, Cancer and Metastasis Reviews.
[97] David A. Williams,et al. Structure-function based design of small molecule inhibitors targeting Rho family GTPases. , 2006, Current topics in medicinal chemistry.
[98] P. Jordan,et al. Rac1, but Not Rac1B, Stimulates RelB-mediated Gene Transcription in Colorectal Cancer Cells* , 2006, Journal of Biological Chemistry.
[99] R. Derynck,et al. SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS , 2005 .
[100] H. Kalthoff,et al. Adhesion and Rac1-dependent Regulation of Biglycan Gene Expression by Transforming Growth Factor-β , 2005, Journal of Biological Chemistry.
[101] D. Albertson,et al. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability , 2005, Nature.
[102] R. Mason,et al. RhoGTPase activation is a key step in renal epithelial mesenchymal transdifferentiation. , 2005, Journal of the American Society of Nephrology : JASN.
[103] E. Lengyel,et al. Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation , 2004, Oncogene.
[104] Shinya Kuroda,et al. Mesenchymal-epithelial transition during somitic segmentation is regulated by differential roles of Cdc42 and Rac1. , 2004, Developmental cell.
[105] Yi Zheng,et al. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[106] Radovan Dvorsky,et al. Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase* , 2004, Journal of Biological Chemistry.
[107] John G. Collard,et al. Tumor-related Alternatively Spliced Rac1b Is Not Regulated by Rho-GDP Dissociation Inhibitors and Exhibits Selective Downstream Signaling* , 2003, Journal of Biological Chemistry.
[108] N. Goto,et al. Effect of Wf-536, a novel ROCK inhibitor, against metastasis of B16 melanoma , 2003, Cancer Chemotherapy and Pharmacology.
[109] Gábor Sirokmány,et al. Central role for Rho in TGF-β1-induced α-smooth muscle actin expression during epithelial-mesenchymal transition , 2003 .
[110] V. Kaartinen,et al. TGFbeta3-induced activation of RhoA/Rho-kinase pathway is necessary but not sufficient for epithelio-mesenchymal transdifferentiation: implications for palatogenesis. , 2002, International journal of molecular medicine.
[111] H. Hidaka,et al. The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway. , 2002, Pharmacology & therapeutics.
[112] Tatjana Crnogorac-Jurcevic,et al. Gene expression profiles of pancreatic cancer and stromal desmoplasia , 2001, Oncogene.
[113] R. Firtel,et al. Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[114] A. Hall,et al. Rho GTPases and the actin cytoskeleton. , 1998, Science.
[115] Shuh Narumiya,et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension , 1997, Nature.
[116] H. Friess,et al. Enhanced expression of transforming growth factor β isoforms in pancreatic cancer correlates with decreased survival , 1993 .
[117] C. Joo,et al. MicroRNA-124 Controls Transforming Growth Factor β1-Induced Epithelial-Mesenchymal Transition in the Retinal Pigment Epithelium by Targeting RHOG. , 2016, Investigative ophthalmology & visual science.
[118] C. Vlaar,et al. Development of EHop-016: a small molecule inhibitor of Rac. , 2013, The Enzymes.
[119] S. Souchelnytskyi,et al. Inhibition of TGFβ signaling and its implications in anticancer treatments. , 2012, Experimental oncology.
[120] T. Rabsilber,et al. Lens Epithelial Cells , 2012 .
[121] M. Olson,et al. Differing contributions of LIMK and ROCK to TGFβ-induced transcription, motility and invasion. , 2011, European journal of cell biology.
[122] J. Wrana,et al. Transforming growth factor-beta-stimulated endocardial cell transformation is dependent on Par6c regulation of RhoA. , 2008, The Journal of biological chemistry.
[123] R. Derynck,et al. Specificity and versatility in tgf-beta signaling through Smads. , 2005, Annual review of cell and developmental biology.
[124] Gábor Sirokmány,et al. Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition. , 2003, American journal of physiology. Renal physiology.
[125] T. Seufferlein,et al. Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation. , 2001, Cancer research.
[126] H. Nagumo,et al. Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells. , 2000, American journal of physiology. Cell physiology.
[127] H. Friess,et al. Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival. , 1993, Gastroenterology.